Prevalence and profile of “seasonal frequent flyers” with chronic heart disease: Analysis of 1598 patients and 4588 patient-years follow-up

Loader, Jordan; Chan, Yih-Kai; Hawley, John A.; Moholdt, Trine; McDonald, Christine F; Jhund, Pardeep S.; Petrie, Mark C.; McMurray, John J.V.; Scuffham, Paul Anthony; Ramchand, Jay; Burrell, Louise M.; Stewart, Simon

doi:10.1016/j.ijcard.2018.12.060

Cited by 3 publications

(2 citation statements)

References 43 publications

(54 reference statements)

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“…The effect of seasons and temperature alterations on CVD has been investigated for a century (Loader et al., 2019; Marti‐Soler et al., 2014; Modesti et al., 2018; Stewart et al., 2017). A study published in 1926 showed that the mortality risk associated with the circulatory system is higher in cold seasons (Bundesen & Falk, 1926).…”

Section: Discussionmentioning

confidence: 99%

Seasonal fluctuation of erectile dysfunction: A cross‐sectional study from a tertiary university hospital across 10 years

et al. 2021

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Erectile dysfunction (ED) shares several risk factors with diabetes mellitus (DM), hypertension (HT) and coronary vascular disease (CVD), which were well‐associated with seasonal fluctuation with the highest peak in winter. In this study, we aimed to determine whether ED demonstrates seasonal fluctuations with the above‐mentioned systemic diseases. Database from a tertiary university hospital between 2010 and 2020 was deciphered to retrieve patients diagnosed with ED. Patients with primary bladder tumour and post‐procedural ED constituted the negative control groups from the same study period. International index of erectile function questionnaire (IIEF‐15) was used to segregate included patients into mild/moderate and severe ED groups. The probability of detecting DM, HT and CVD in patients with severe ED was significantly higher than that of with mild/moderate ED (p < 0.05). More ED symptoms emerged and were diagnosed in the winter seasons even though no statistical significance was observed between patients with mild/moderate and severe ED (p = 0.946, Cramer's V coefficient = 0.19). The seasonal variation of patients with bladder tumour and post‐procedural ED groups showed no significant difference (p > 0.05, both). ED admissions are associated with higher peaks in the winter seasons. This may help in daily clinical practice to warrant better clinical and epidemiological interpretation of ED.

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Section: Discussionmentioning

confidence: 99%

Seasonal fluctuation of erectile dysfunction: A cross‐sectional study from a tertiary university hospital across 10 years

et al. 2021

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“…As with any other debilitating chronic condition, an individual’s journey with HF, while often punctuated by acute hospital episodes and premature mortality (frequently in winter), typically occurs in a community setting. [ 2 ]…”

Section: Heart Failure and Primary Carementioning

confidence: 99%

Out with the Old and In with the New: Primary Care Management of Heart Failure with Preserved Ejection Fraction

Stewart

Stewart²,

Waite

et al. 2022

Card Fail Rev

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Primary care plays an integral role in the management of complex, chronic disease states such as heart failure. However, there is a disconnect between the characteristics of those recruited into clinical trials and those managed in the real world, which means the contribution and consideration of primary care in current guidelines is suboptimal. In this article, the authors explore key issues in the diagnosis and management of heart failure that need to be addressed from a primary care perspective. This article focuses on the issue of heart failure with preserved ejection fraction and the integration of new clinical epidemiology and trial evidence into clinical practice. In response, the authors advocate for dedicated guidelines for the primary care management of heart failure, the development of strategies to facilitate communications between health professionals in acute and community care and a renewed focus on researching optimal models of heart failure care in the community.

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An inevitable or modifiable trajectory towards heart failure in high-risk individuals: insights from the nurse-led intervention for less chronic heart failure (NIL-CHF) study

Chan

Stickland

Stewart

2022

European Journal of Cardiovascular Nursing

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Aims We extended follow-up of a heart failure (HF) prevention study to determine if initially positive findings of improved cardiac recovery were translated into less de novo HF and/or all-cause mortality (primary endpoint) in the longer term. Methods and results The Nurse-led Intervention for Less Chronic HF (NIL-CHF) study was a single-centre randomized trial of nurse-led prevention involving cardiac inpatients without HF. At 3 years, 454 survivors (aged 66 ± 11 years, 71% men and 68% coronary artery disease) had the following: (i) a normal echocardiogram (128 cases/28.2%), (ii) structural heart disease (196/43.2%), or (iii) left ventricular diastolic dysfunction/left ventricular systolic dysfunction (LVDD/LVSD: 130/28.6%). Outcomes were examined during median 8.3 (interquartile range 7.8–8.8) years according to these hierarchal groups and change in cardiac status from baseline to 3 years. Overall, 109 (24.0%) participants had a de novo HF admission or died while accumulating 551 cardiovascular-related admissions/3643 days of hospital stay. Progressively worse cardiac status correlated with increased hospitalizations (P < 0.001). The mean rate (95% confidence interval) of cardiovascular admissions/days of hospital stay being 0.09 (0.05–0.12) admissions/0.33 (0.13–0.54) days vs. 0.27 (0.20–0.34) admissions/2.20 (1.36–3.04) days per annum for those with a normal echocardiogram vs. LVDD/LVSD at 3 years. With progressively higher event rates, the adjusted hazard ratio for a de novo HF admission and/or death associated with a structural abnormality (24.5% of cases) and LVDD/LVSD (36.2%) at 3 years was 1.57 (0.82–3.01; P = 0.173) and 2.07 (1.05–4.05; P = 0.035) compared with a normal echocardiogram (10.9%). Mortality also mirrored the direction/extent of cardiac status/trajectory. Conclusions These data suggest the positive initial effects of NIL-CHF intervention on cardiac recovery contributed to better long-term outcomes among patients at high risk of HF. However, prevention of HF remains challenging.

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Prevalence and profile of “seasonal frequent flyers” with chronic heart disease: Analysis of 1598 patients and 4588 patient-years follow-up

Abstract: All authors takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Cited by 3 publications

References 43 publications

Seasonal fluctuation of erectile dysfunction: A cross‐sectional study from a tertiary university hospital across 10 years

Seasonal fluctuation of erectile dysfunction: A cross‐sectional study from a tertiary university hospital across 10 years

Out with the Old and In with the New: Primary Care Management of Heart Failure with Preserved Ejection Fraction

An inevitable or modifiable trajectory towards heart failure in high-risk individuals: insights from the nurse-led intervention for less chronic heart failure (NIL-CHF) study

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