Prevalence and Postdischarge Incidence of Malignancies in Patients With Acute Coronary Syndrome

Cordero, Alberto; López-Palop, Ramón; Carrillo, Pilar; Núñez, Julio; Frutos, Araceli; Bertomeu-González, Vicente; Yépez, Fernando; Alcantara, N.; Ribes, Francisco; Juskova, M.; Bertomeu‐Martínez, Vicente

doi:10.1016/j.rec.2017.07.020

Cited by 6 publications

(10 citation statements)

References 32 publications

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“…The smaller prevalence in our study could be attributed to the difference in the study population between our study and the previous study (i.e., ACS only vs. ischemic heart disease including acute and chronic coronary syndrome, respectively). Another singlecenter prospective study of 1,819 patients with ACS showed a cancer prevalence of 3.4%, 8 and a retrospective study including 6,068 patients showed a prevalence of 9.6%, 26 which is almost consistent with the result of our study.…”

Section: Discussionsupporting

confidence: 91%

“…This study reconfirmed that cancer comorbidity is associated with poor long-term prognosis in patients with ACS, which is consistent with previous reports. [8][9][10][11] This study also identified smoking history, age ≥65 years, high RAR, and high D-dimer level as positive predictors of cancer incidence. Among the patients with ACS and these 4 predictors, 25% developed cancer after discharge.…”

Section: Discussionmentioning

confidence: 63%

“…8-10,26,27 A previous study showed that prevalent and incident cancers are strongly associated with a high risk of all-cause death, which increased by 4-or 5-fold. 8 The French registry on acute STEMI or non-STEMI showed that non-cardiovascular death occurred more frequently during the first 1 year, and the HR for non-cardiovascular death before 12 months in AMI survivors with a history of cancer was 5.08 (95% CI 2.84-9.09). 10 Similarly, our study showed that patients with ACS with prevalent cancer had a 6-or 7-fold increased risk of all-cause death.…”

Section: Discussionmentioning

confidence: 99%

“…The SARAD scoring system comprises 4 factors: smoking history, age ≥65 years, high RAR, and high D-dimer level; smoking history, age, and high D-dimer level are known risk factors for cancer incidence. 8,11,36,37 The RDW is a measurement of the variability of the erythrocyte volume and reflects inflammatory conditions. 38 Recently accumulated evidence shows the prognostic implication of RDW in patients with cancer and indicates that an increase in the RDW level could be a negative predictor of cancer prognosis.…”

Section: Discussionmentioning

confidence: 99%

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Risk Prediction Score for Cancer Development in Patients With Acute Coronary Syndrome

Ishii

Marume

Nakai

et al. 2024

Circ J

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Risk Prediction Score for Cancer Development in Patients With Acute Coronary Syndrome

Ishii

Marume

Nakai

et al. 2024

Circ J

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“…Cardiovascular disease (CVD) and cancer are the two major causes of mortality worldwide (1,2). Recently, an increased risk of cancer development has been reported in patients affected by CVD, particularly acute coronary syndrome (ACS) (3)(4)(5)(6). Variation in cancer incidence has been observed between urban and rural areas for several decades, with higher risk of cancer in urban populations (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Risk of Malignancy Long After Acute Coronary Syndrome in Selected Urban and Rural Areas and Comparison With Smoking Risk: The ABC-7* Study on Heart Disease. (*ABC is An Acronym for Adria, Bassano, Conegliano, and Padova Hospitals)

Berton¹,

Mahmoud

Palmieri³

et al. 2020

Preprint

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Background Increased cancer risk has been reported in patients with acute coronary syndrome (ACS). Objectives To investigate geographic differences in risk malignancy long after ACS. Methods We enrolled 586 ACS patients admitted to hospitals in three provinces in the Veneto region of Italy in this prospective study. Patient's residency was classified into three urban and three nearby rural areas. Results All (except for 3) patients completed the follow-up (22 years or death) and 54% were living in rural areas. Sixteen patients had pre-existing malignancy, and 106 developed the disease during follow-up. Cancer prevalence was 17% and 24% (p=0.05) and incidence of malignancy was 16 and 21/1000 person-years for urban and rural areas, respectively. In unadjusted logistic regression analysis, cancer risk increased from urban to rural areas (odds ratio [OR] 3.4;95% confidence interval [CI] 1.7-7.1; p=0.001), with little change from north to south provinces (OR 1.5;95% CI 1.0-2.2; p=0.06). Yet, we found a strong positive interaction between urban-rural areas and provinces (OR 2.1;95% CI 1.2-3.5; p=0.003). These results kept true in the fully adjusted model. Unadjusted Cox regression analysis revealed increasing hazards ratios (HRs) for malignancy onset from urban to rural areas (HR 3.0;95% CI 1.5-6.2; p=0.02), but not among provinces (HR 1.3;95% CI 1.0-2.0; p=0.14). Also, we found a strong positive interaction between geographic areas (HR 2.1;95% CI 1.3-3.5; p=0.002), even with a fully adjusted model. Conclusion The results in unselected real-world patients demonstrate a significant geographic difference in malignancy risk in ACS patients, with the highest risk in the north-rural area.

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Heart failure during acute coronary syndrome and the long‐term cancer risk: the ABC‐9^† Study on heart disease

Mahmoud,

Berton,

Cordiano

et al. 2024

ESC Heart Failure

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AimsA higher risk of cancer among patients with heart failure (HF) has been suggested in recent community‐based studies. This study aimed to investigate the impact of HF during hospitalization with acute coronary syndrome (ACS) on the long‐term cancer risk.Methods and resultsThe study included 572 patients admitted with ACS to three Italian hospitals, discharged cancer‐free, and prospectively followed for 24 years or until death. All but three patients completed the follow‐up, which represented 6440 person‐years (mean age: 66 ± 12 years; 70% males). Baseline HF was diagnosed in 192 (34%) patients. A total of 129 (23%) patients developed cancer (103 without HF and 26 with HF), and 107 (19%) patients died due to it (81 without HF and 26 with HF). The incidence rates for cancer onset and cancer death were not different according to HF status. Cox regression analysis revealed no association between HF or left ventricular ejection fraction (LVEF) and cancer risk. In addition, no difference in cancer risk was observed among patients with HF with preserved ejection fraction, HF with mildly reduced ejection fraction, and HF with reduced ejection fraction. In competing risk regression analysis, the risk of cancer onset associated with HF was sub‐hazard ratio (SHR) 0.47 [95% confidence interval (CI): 0.30–0.72; P = 0.001] and SHR 1.02 (95% CI: 1.01–1.04; P = 0.002) with LVEF. Results were the same in the adjusted model. Yet the fully adjusted model showed an attenuated association between cancer death and HF (SHR: 0.63; 95% CI: 0.37–1.05; P = 0.08) and LVEF (SHR: 1.02; 95% CI: 0.99–1.06; P = 0.08). Consistent results were obtained after using propensity score matching analysis that created 192 pairs. A negative interaction between age and HF and a positive interaction between age and LVEF for cancer risk have also been found.ConclusionsAn inverse association between baseline HF and long‐term cancer risk has been observed among the ABC Study on heart disease patients who were followed for 24 years after ACS.

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Prevalence and Postdischarge Incidence of Malignancies in Patients With Acute Coronary Syndrome

Cited by 6 publications

References 32 publications

Risk Prediction Score for Cancer Development in Patients With Acute Coronary Syndrome

Risk Prediction Score for Cancer Development in Patients With Acute Coronary Syndrome

Risk of Malignancy Long After Acute Coronary Syndrome in Selected Urban and Rural Areas and Comparison With Smoking Risk: The ABC-7* Study on Heart Disease. (*ABC is An Acronym for Adria, Bassano, Conegliano, and Padova Hospitals)

Heart failure during acute coronary syndrome and the long‐term cancer risk: the ABC‐9^† Study on heart disease

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Prevalence and Postdischarge Incidence of Malignancies in Patients With Acute Coronary Syndrome

Cited by 6 publications

References 32 publications

Risk Prediction Score for Cancer Development in Patients With Acute Coronary Syndrome

Risk Prediction Score for Cancer Development in Patients With Acute Coronary Syndrome

Risk of Malignancy Long After Acute Coronary Syndrome in Selected Urban and Rural Areas and Comparison With Smoking Risk:&nbsp;The ABC-7* Study on Heart Disease.&nbsp;(*ABC is An Acronym for Adria, Bassano, Conegliano, and Padova Hospitals)

Heart failure during acute coronary syndrome and the long‐term cancer risk: the ABC‐9† Study on heart disease

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Product

Resources

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Risk of Malignancy Long After Acute Coronary Syndrome in Selected Urban and Rural Areas and Comparison With Smoking Risk: The ABC-7* Study on Heart Disease. (*ABC is An Acronym for Adria, Bassano, Conegliano, and Padova Hospitals)

Heart failure during acute coronary syndrome and the long‐term cancer risk: the ABC‐9^† Study on heart disease