Background: The sexually transmitted infections are common communicable diseases spread through sexual contacts and caused by a broad range of pathogens, e. g., bacteria, chlamydia, virus, fungus, protozoa, ectoparasites, etc. Methods: The study was conducted at Community Health Centre, Rangat, Middle Andaman. This was a cross sectional study involving all the patients attended CHC, Rangat during the period from April, 2017 to October, 2019. The statistical data is expressed as numbers and percentages. Result: 23 patients were diagnosed to have STIs during the study period. Herpes genitalis is the predominant STI diagnosed in 6 patients followed by condyloma acuminata, chancroid, molluscum, trichomonas vaginitis and bacterial vaginosis. Conclusion: Thus, we performed this study to analyse the prevalence of sexually transmitted infection among patients attending CHC, Rangat. This study will be useful for planning and implementation of health care.