Prevalence and pathogenesis of anemia in inflammatory bowel disease. Influence of anti-tumor necrosis factor-  treatment

Bergamaschi, Gaetano; Sabatino, Antonio Di; Albertini, Riccardo; Ardizzone, Sandro; Biancheri, Paolo; Bonetti, Elisa; Cassinotti, A.; Cazzola, P.; Markopoulos, Konstantinos; Massari, A.; Rosti, Vittorio; Porro, G. Bianchi

doi:10.3324/haematol.2009.009985

Cited by 147 publications

(132 citation statements)

References 30 publications

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“…This result indicates that the cumulative diagnosis of anemia increases with IBD disease duration. Thus, the higher rate of anemia identified in our cohort is likely due to this cumulative phenomenon when compared to cross-sectional prevalence studies from many other European countries (16)(17)(18)(19)(20). However, this increased rate of anemia may also be due to other factors; for instance, some of our patients were referrals and, thus, more complicated patients gathered in our cohort.…”

Section: Discussionmentioning

confidence: 56%

“…The higher anemia frequency in patients treated at university hospitals may also be related to the higher proportion of IBD patients with active and/or severe disease at university hospitals. Lastly, some differences in anemia frequency between different IBD centers may be attributed to different health systems operating in different countries; for example, the prevalence of anemia in Italian and Greek IBD patients was found to be higher than that in other Northern European countries (17,18).…”

Section: Discussionmentioning

confidence: 99%

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Incidence rate of anemia in inflammatory bowel diseases

Atuğ

Kani²,

Banzragch³

et al. 2016

Turk J Gastroenterol

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INTRODUCTIONInflammatory bowel diseases (IBD) are relapsing and remitting chronic intestinal disorders with extra-intestinal manifestations (EIM). IBD predominantly consist of two different clinical forms: Crohn's disease (CD) and ulcerative colitis (UC) (1,2).Anemia is a common complication in IBD and has a known negative impact not only on quality of life and but also on the ability to work (3,4). Thus, the detection and treatment of anemia in IBD patients deserves careful consideration with regards to the approach (5). Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are major causes of anemia in IBD patients (5,6). Vitamin B 12 and/or folate deficiency and drug-induced bone marrow suppression may represent other important contributing factors (7). In cross-sectional studies of IBD series, anemia was reported over a very wide range, from 6% to 74% (8,9). Indeed, the frequency of anemia differs among IBD patient populations and is dependent on hospitalization, IBD type, and remission status. Anemia has been reported to be more frequent in hospitalized patients and CD patient groups but less frequent in patients with clinical remission. In a recent review, the mean prevalence of anemia in an IBD patient population was 17% (16% in outpatients and 68% in hospitalized patients), with anemia occurring more frequently in patients with CD than in patients with UC (5,8). However, scarce information is available regarding the incidence rate of anemia over time in IBD cohorts. The anemia prevalence of Turkish IBD patients is also unknown.The main aim of this study was to determine the incidence rate and distribution of anemia types over time in an IBD patient cohort spanning 18 years from a single tertiary center in Turkey. Conclusion: This is the first study to report the incidence rate of anemia (103.45 per 1,000 patient-years) in a longterm cohort of IBD patients.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Incidence rate of anemia in inflammatory bowel diseases

Atuğ

Kani²,

Banzragch³

et al. 2016

Turk J Gastroenterol

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show abstract

“…Accordingly, patients with ACD had higher serum levels of the hepcidin precursor pro-hepcidin compared to IDA subjects and increased pro-hepcidin levels were associated with elevated ferritin concentrations, supporting a role of hepcidin in the pathogenesis of IBD-associated anemia and nicely resembling observations made in rheumatic and infectious diseases. 6 Most interestingly, Bergamaschi et al 27 present data on the therapeutic effects of anti-TNF-α treatment with infliximab on the resolution of anemia in a subgroup of patients with Crohn's disease. They found that patients who responded to treatment started to have an improvement in their anemia within 2 weeks after the first infusion of infliximab.…”

Section: Treatmentmentioning

confidence: 99%

“…1 In this issue of the Journal, Bergamaschi et al present a careful analysis of anemia in patients with IBD. 27 In an assessment of 263 out-patients with IBD, they observed that almost two-thirds of their patients were anemic at diagnosis and that the relative percentage was slightly higher in subjects with Crohn's disease than in patients suffering from ulcerative colitis. Treatment of IBD gradually increased hemoglobin levels over time but 35% of all patients remained anemic, indicating that anemia is a frequent and so far underestimated complication in patients with IBD.…”

Section: Treatmentmentioning

confidence: 99%

Pathogenesis and treatment of anemia in inflammatory bowel disease

Weiss¹,

Gasché²

2010

Haematologica

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“…Более верное название для этого синдрома -«анемия воспаления», т. к. воспаление, в т. ч. острое, является центральным зве-ном в патогенезе развития анемии, и не все хронические заболевания могут приводить к развитию анемии хрони-ческих заболеваний [19]. Распространенность анемии хронических заболеваний у взрослых в структуре анемии составляет 33%, у подростков -17%, у детей в возрасте до 10 лет -7% [20].…”

Section: вопросы современной педиатрииunclassified