Prevalence and epidemiology of toenail onychomycosis in diabetic subjects: a multicentre survey

Gupta, Aditya K.; Konnikov, Nellie; MacDonald, Paul; Rich, Phoebe; Rodger, N. W.; Edmonds, Michael; McManus, Ruth; Summerbell, Richard C.

doi:10.1046/j.1365-2133.1998.02464.x

Cited by 275 publications

(306 citation statements)

References 15 publications

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“…Most authors have frequently identifi ed dermatophytes as agents (80 to 90%), followed by yeasts (5 to 17%) and nondermatophytic fi lamentous fungi (2 to 12%) 17,18 , in agreement with the present study.…”

supporting

confidence: 82%

Eco-epidemiologic study of emerging fungi related to the work of babaçu coconut breakers in the State of Maranhão, Brazil

Nascimento

Leitão

Silva

et al. 2014

Rev. Soc. Bras. Med. Trop.

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introduction:There are more than 300,000 extractors using the babaçu coconut as a source of income in the States of Maranhão, Pará, Tocantins and Piauí, and this activity is associated with fungal infections. The objective of this study was to examine the occurrence of emergent fungi in the conjunctiva, nails and surface and subcutaneous injuries of female coconut breakers in Esperantinópolis, Maranhão. Additionally, soil samples and palm structures were collected. Methods: The obtained samples were cultured in Petri dishes containing potato-dextrose-agar and chloramphenicol. The etiological agent was confi rmed by a direct mycological exam and growth in culture. Results: In total, 150 domiciles were visited, and samples were collected from 80 patients. From the ground, the most frequently isolated fungus was Aspergillus niger (53. 8%). the most frequently detected fungus in babaçu coconut was Aspergillus niger (66.7%). Conjunctival fungal growth occurred in 76.3% of the women. The ocular fungal microbiota consisted of fi lamentous fungi (80.6%), and yeasts were present in 19.4% of cases. Onychomycosis was diagnosed in 44% (11/25) of the women. Conclusions: The identifi cation of the genera Neosartorya, Rhizopus and Curvularia in onychomycoses shows that emergent fi lamentous fungi can be isolated. Aspergillus sp., Penicillium sp. and Scedosporium sp. were the predominant genera found in the babaçu coconut. From ocular conjunctiva, Candida spp. were the most prevalent species isolated, and Fusarium sp. was present only in one woman. The nearly permanent exposure of coconut breakers to the external environment and to the soil is most likely the reason for the existence of a mycotic fl ora and fungal infections, varying according to the individual's practices and occupation.

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supporting

confidence: 82%

Eco-epidemiologic study of emerging fungi related to the work of babaçu coconut breakers in the State of Maranhão, Brazil

Nascimento

Leitão

Silva

et al. 2014

Rev. Soc. Bras. Med. Trop.

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“…In particular, a multicenter survey (8) reports that the administration of immunosuppressive agents to people with diabetes may be an important factor that predisposes patients to onychomycosis.…”

mentioning

confidence: 99%

Establishment of a Novel Model of Onychomycosis in Rabbits for Evaluation of Antifungal Agents

Shimamura

Kubota

Nagasaka

et al. 2011

Antimicrob Agents Chemother

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We developed a novel model of onychomycosis in which we observed fungi in the deep layer of the nail, and we used the model to evaluate the efficacy of two topical antifungal drugs. To establish an experimental, in vivo model of onychomycosis, we applied Trichophyton mentagrophytes TIMM2789 to the nails of the hind limbs of rabbits that underwent steroid treatment. The nails were taken from the rabbits' feet at 0, 2, and 6 weeks after a 2-week infection. The localization of the fungi was evaluated histopathologically. Some fungi were seen to penetrate to the nail bed, and the infection rate in the sample at 0, 2, and 6 weeks after infection was 57, 87, and 93%, respectively. In addition, fungi proliferated and moved proximally into the nail plate in a manner that depended on the duration of infection. Second, using this model we evaluated antifungal efficacy both by the culture recovery method and histopathological examination. Two topical antifungal drugs, 8% ciclopirox nail lacquer and 5% amorolfine nail lacquer, were applied to the nail for 4 weeks in each group. On histopathological examination, two antifungal treatment groups showed no significant difference against the nontreated control group. However, there were a significantly low fungus-positive rate and intensity of the recovery of fungi on culture between antifungal treatment and nontreated control groups. We therefore suggest that we have established an in vivo model of onychomycosis that is useful for the evaluation of the efficacy of antifungal agents.

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“…We didn't find (Dermatitis herpeat iformis, juvenile dermatomyositis, pemphigus vulgaris). Those diseases and juvenile DM have definite HLA associations [13].…”

Section: Discussionmentioning

confidence: 99%

Dermatological Manifestations among Diabetic Children (0-16) Years in Jaber Abo Eliz Diabetic Center, Albulk Children Hospital, in Khartoum, Sudan (March, 2011-March, 2012)

Salih¹

2017

JPNC

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Prevalence and epidemiology of toenail onychomycosis in diabetic subjects: a multicentre survey

Cited by 275 publications

References 15 publications

Eco-epidemiologic study of emerging fungi related to the work of babaçu coconut breakers in the State of Maranhão, Brazil

Eco-epidemiologic study of emerging fungi related to the work of babaçu coconut breakers in the State of Maranhão, Brazil

Establishment of a Novel Model of Onychomycosis in Rabbits for Evaluation of Antifungal Agents

Dermatological Manifestations among Diabetic Children (0-16) Years in Jaber Abo Eliz Diabetic Center, Albulk Children Hospital, in Khartoum, Sudan (March, 2011-March, 2012)

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