Prevalence and distribution of antimicrobial resistance determinants of Escherichia coli isolates obtained from meat in South Africa

Jaja, Ishmael Festus; Oguttu, James Wabwire; Iwu, Chinwe Juliana; Green, Ezekiel

doi:10.1371/journal.pone.0216914

Cited by 29 publications

(29 citation statements)

References 33 publications

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“…Prolonged illness, disability, and death occur when microorganisms do not respond to standard treatment (Jindal et al, 2015;WHO, 2018). Studies from sub-Saharan Africa have reported high AMR (Alabi et al, 2013;Jaja et al, 2020;Llor and Bjerrum, 2014). Routine AMR monitoring in small cohort studies such as these is equally important to understand the actual burden of AMR in the community.…”

Section: Discussionmentioning

confidence: 99%

High prevalence of antibiotic-resistant Escherichia coli in Congolese students

Mapanguy

Adedoja

Kecka

et al. 2021

International Journal of Infectious Diseases

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Background: Antimicrobial resistance (AMR) is of growing concern worldwide, and the AMR status in sub-Saharan Africa (SSA), including the Republic of the Congo, is largely undetermined due to a lack of realtime monitoring. As the incidence of multi-resistant Escherichia coli has been increasing in recent years, an investigation was performed to determine the antibiotic resistance of E. coli isolated from stool samples of Congolese students. Furthermore, factors associated with the carriage of resistant bacteria were investigated. Methods: A total of 339 stool samples from 339 high school students living in the Madibou area of Brazzaville, Republic of Congo, were tested for E. coli. Isolates obtained were tested for susceptibility to 10 antibiotics that are widely used in the region. Results: One hundred and seventy-three (51%) individuals were E. coli-positive in stool, with 61% being female students. Antimicrobial resistance was highest for ceftazidime (65%), followed by amoxicillin (57%), piperacillin-tazobactam (51%), ofloxacin (11%), azithromycin (8%), ciprofloxacin (4%), nalidixic acid (2%), and amoxicillin-clavulanic acid (1%). Antibiotic procurement from non-legalized local vendors had a significant impact on E. coli positivity and antibiotic resistance when compared to procurement from state-licensed pharmacies (p < 0.05). Conclusions: The high prevalence of resistant commensal E. coli in the community justifies further investigation and urges the need for routine monitoring of antimicrobial susceptibility testing in the region.

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Section: Discussionmentioning

confidence: 99%

High prevalence of antibiotic-resistant Escherichia coli in Congolese students

Mapanguy

Adedoja

Kecka

et al. 2021

International Journal of Infectious Diseases

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“…Our results are consistent with the findings of the studies conducted in Iran, United States, Saudi Arabia, and China, which reported an increasing development of AR against tetracycline of 66.9%, 63%, 90.71%, and 43%, respectively by Salmonella isolates [ 22 , 23 , 24 , 25 ]. In South Africa, over 70% of the antibiotics used in livestock production are available over the counter [ 26 ], and this contributes to the increased prevalence of AR in the country. Tetracyclines have been an important class of antibiotics in the health and production of food animals for decades, as they are used in veterinary medicine for illness prevention and control [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to a survey conducted by Eagar et al [ 33 ], 16.7% and 12.4% of tetracyclines and sulphonamides were commonly used antibiotics in animals in South Africa between the years 2002 and 2004. The Stock Remedies Act of 1947 in South Africa consents tetracycline to be purchased over the counter without a prescription from a veterinarian [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Antibiotic Resistance in Salmonella Serotypes Concurrently Isolated from the Environment, Animals, and Humans in South Africa: A Systematic Review and Meta-Analysis

et al. 2021

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One of the main global concerns is the usage and spread of antibiotic resistant Salmonella serovars. The animals, humans, and environmental components interact and contribute to the rapid emergence and spread of antimicrobial resistance, directly or indirectly. Therefore, this study aimed to determine antibiotic resistance (AR) profiles of Salmonella serotypes isolated from the environment, animals, and humans in South Africa by a systematic review and meta-analysis. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were followed to search four databases for studies published from 1980 to 2021, that reported the antibiotic resistance profiles of Salmonella serotypes isolated in South Africa. The AR was screened from 2930 Salmonella serotypes which were isolated from 6842 samples. The Western Cape province had high pooled prevalence estimates (PPE) of Salmonella isolates with AR profiles followed by North West, Gauteng, and Eastern Cape with 94.3%, 75.4%, 59.4%, and 46.2%, respectively. The high PPE and heterogeneity were observed from environmental samples [69.6 (95% CI: 41.7−88.3), Q = 303.643, I2 = 98.353, Q-P = 0.045], animals [41.9 (95% CI: 18.5–69.5), Q = 637.355, I2 = 98.745, Q-P = 0.577], as well as animals/environment [95.9 (95% CI: 5.4−100), Q = 55.253, I2 = 96.380, Q-P = 0.300]. The majority of the salmonella isolates were resistant to sulphonamides (92.0%), enrofloxacin and erythromycin (89.3%), oxytetracycline (77.4%), imipenem (72.6%), tetracycline (67.4%), as well as trimethoprim (52.2%), among the environment, animals, and humans. The level of multidrug-resistance recorded for Salmonella isolates was 28.5% in this review. This study has highlighted the occurrence of AR by Salmonella isolates from animals, humans, and environmental samples in South Africa and this calls for a consolidated “One Health” approach for antimicrobial resistance epidemiological research, as well as the formulation of necessary intervention measures to prevent further spread.

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“…A total of 12 E. coli isolates (92.31%) isolated from se'i meat samples showed resistance to two or more Kallau et al (2018) showed 57.3% prevalence of MDR E. coli isolates with 39 resistance patterns. Jaja et al (2020) reported a total of 20 MDR patterns with 3-10 antibiotic classes of E. coli isolates. Antibiotic-resistant E. coli in animal products can seriously threat public health (Rahman et al, 2017).…”

Section: Percentage Of Multidrug Resistant (Mdr) E Coli Isolated From Se'i Meatmentioning

confidence: 99%

Escherichia coli CONTAMINATION AND ITS RESISTANCE TO ANTIBIOTICS IN SE’I MEAT

2021

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The purpose of this study was to obtain Escherichia coli isolates from 11 se’i meat sellers in Kupang City and to observe their resistance to13 types of antibiotics. Escherichia coli were isolated and identified based on SNI 2897: 2008. Antibiotic resistance of the Escherichia colii isolates was determined using the Kirby-Bauer method. The results showed that 13 isolates (39.39%) of Escherichia coli in se’i meat samples had a high level of resistance to erythromycin (100%), tetracycline (76.92%), and doxycycline (61.54%). Isolates demonstrated increased resistance to streptomycin (46.15%), cephalothin (38.46%), trimethoprim-sulfamethoxazole (38.46%), amoxicillin (30.77%), chloramphenicol (30.77%), and choline sulfate (30.77%). The antibiotics nalidixic acid and ciprofloxacin demonstrated low Escherichia coli resistance (7.69%). Escherichia coli are sensitive to cefotaxime and gentamicin. A total of 12 isolates (92.31%) experienced MDR. The presence of non-MDR and MDR resistant Escherichia coli in se’i meat can seriously threaten community health.

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Prevalence and distribution of antimicrobial resistance determinants of Escherichia coli isolates obtained from meat in South Africa

Cited by 29 publications

References 33 publications

High prevalence of antibiotic-resistant Escherichia coli in Congolese students

High prevalence of antibiotic-resistant Escherichia coli in Congolese students

Prevalence of Antibiotic Resistance in Salmonella Serotypes Concurrently Isolated from the Environment, Animals, and Humans in South Africa: A Systematic Review and Meta-Analysis

Escherichia coli CONTAMINATION AND ITS RESISTANCE TO ANTIBIOTICS IN SE’I MEAT

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