Prevalence and correlates of childhood anemia in the MINA-Brazil birth cohort study

Abstract

OBJECTIVE This study aimed to describe the prevalence and predictors of childhood anemia in an Amazonian population-based birth cohort study. METHODS Prevalence of maternal anemia was estimated at delivery (hemoglobin [Hb] concentration < 110 g/L) in women participating in the MINA-Brazil birth cohort study and in their children, examined at ages one, two (Hb < 110 g/L), and five (Hb < 115 g/L). Moreover, ferritin, soluble transferrin receptor, and C-reactive protein concentrations were measured in mothers at delivery and in their 1- and 2-year-old children to estimate the prevalence of iron deficiency and its contribution to anemia, while adjusting for potential confounders by multiple Poisson regression analysis (adjusted relative risk [RR a ]). RESULTS The prevalence 95% confidence interval (CI) of maternal anemia, iron deficiency, and iron-deficiency anemia at delivery were 17.3% (14.0–21.0%), 42.6% (38.0–47.2%), and 8.7% (6.3–11.6)%, respectively (n = 462). At one year of age (n = 646), 42.2% (38.7–45.8%) of the study children were anemic, 38.4% (34.6–42.3%) were iron-deficient, and 26.3 (23.0–29.9) had iron-deficiency anemia. At two years of age (n = 761), these values decreased to 12.8% (10.6–15.2%), 18.1% (15.5–21.1%), and 4.1% (2.8–5.7%), respectively; at five years of age (n = 655), 5.2% (3.6–7.2%) were anemic. Iron deficiency (RR a = 2.19; 95%CI: 1.84–2.60) and consumption of ultra-processed foods (UPF) (RR a = 1.56; 95%CI: 1.14–2.13) were significant contributors to anemia at 1 year, after adjusting for maternal schooling. At 2 years, anemia was significantly associated with maternal anemia at delivery (RR a : 1.67; 95%CI: 1.17–2.39), malaria since birth (2.25; 1.30–3.87), and iron deficiency (2.15; 1.47–3.15), after adjusting for children's age and household wealth index. CONCLUSIONS Anemia continues to be highly prevalent during pregnancy and early childhood in the Amazon. Public health policies should address iron deficiency, UPF intake, maternal anemia, and malaria to prevent and treat anemia in Amazonian children.

MINA-Brasil - uma coorte de nascimentos para estudar a saúde e a nutrição na Amazônia

“…Vitamin A status and malaria contributed to persistent anemia at two years of age in this population. 7 …”

“…Deficiência e insuficiência de vitamina A também foram comuns durante a gravidez (6% e 20%, respectivamente) e em crianças de 2 anos (25% e 42%, respectivamente), mas substancialmente menos frequentes no primeiro ano de vida (2% e 10%, respectivamente), quando a anemia infantil foi mais prevalente. O estado de vitamina A e a malária contribuíram para a anemia persistente aos dois anos de vida nessa população 7 .…”