Prevalence and clinical spectrum of skin disease in patients infected with human immunodeficiency virus

Coldiron, B. M.

doi:10.1001/archderm.125.3.357

Cited by 59 publications

(55 citation statements)

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“…Goodman et al .,[16] reported higher prevalence, whereas a south western France study[18] showed that it is relatively lower (65.3%). Seborrheic dermatitis (74.16%) was the most common dermatological disorder according to our study, which is consistent with other studies[1621] where seborrheic dermatitis and candidiasis were the most common findings. A study[19] reported dermatophytosis as the most common manifestation.…”

Section: Discussionsupporting

confidence: 93%

“…[1516] Some Cutaneous disorders reflect the progression of HIV disease,[1315] but this relation is still controversial. [1617] Extensive HIV-related literature has focused on distinctive clinical presentations such as Kaposi's sarcoma, oral hairy leukoplakia, and oral candidiasis. [1517] However, the findings on careful skin examination of HIV infected patients who present for primary care have received limited attention.…”

Section: Introductionmentioning

confidence: 99%

“…[1617] Extensive HIV-related literature has focused on distinctive clinical presentations such as Kaposi's sarcoma, oral hairy leukoplakia, and oral candidiasis. [1517] However, the findings on careful skin examination of HIV infected patients who present for primary care have received limited attention. Here, we describe systematic dermatological manifestations of HIV infected patients on initial presentation.…”

Section: Introductionmentioning

confidence: 99%

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Dermatological manifestations in HIV-infected patients at a tertiary care hospital in a tribal (Bastar) region of Chhattisgarh, India

Singh

Tiwari

et al. 2009

Indian J Dermatol

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Background:Cutaneous disorders during HIV infection are numerous and skin is often the first and only organ affected during most of the course of HIV disease. Some Cutaneous disorders reflect the progression of HIV disease; though the relation is still controversial.Aims:The objective of this study, conducted at a tertiary care centre in Bastar, Jagdalpur, is to estimate the status of cutaneous manifestation in HIV-infected patients and its relationship with CD4 cell counts.Methods:We enrolled 137 HIV positive subjects. Demographic information such as age, gender, weight, height, socioeconomic status, and educational status were recorded. Laboratory parameter (CD4 counts) and treatment regimen were noted. Patients were examined for skin disorders by a dermatologist. Data were analyzed using chi-square test for categorical variables.Results:Majority of the patients were from rural area (65.69%) and belonged to a low socioeconomic and educational status. 30.65% of the patients were housewives, 23.35% drivers, and 16.78% labourers. Predominant mode of transmission was heterosexual contact (94.16%). Most common HIV-related dermatological manifestations were seborrheic dermatitis (74.16%), xerosis (52.5%), generalized skin hyperpigmentation 56 (46.67%), onychomycosis 53 (44.16%), pruritic papular eruption 27 (22.5%), oral candidiasis 21 (17.5%), photo dermatitis 21 (17.5%), and scabies 4 (3.33%). Significant correlation with low CD4+ cell counts was found for oral candidiasis (P < 0.0001) and Kaposi's sarcoma (P = 0.03), while other disorders such as seborrheic dermatitis (P = 0.22), xerosis (P = 0.25), and onychomycosis (P = 0.08) were not statistically significant.Conclusion:This study showed high prevalence of dermatological manifestations in HIV-infected subjects, and they occur more frequently with progression of HIV and decline in immune functions. Therefore, early diagnosis and management of skin disorders can improve the quality of life of HIV-infected subjects.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dermatological manifestations in HIV-infected patients at a tertiary care hospital in a tribal (Bastar) region of Chhattisgarh, India

Singh

Tiwari

et al. 2009

Indian J Dermatol

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“…In some patients, skin is the first organ affected. [1] Skin diseases have proved to be sensitive and useful measures by which HIV progression can be monitored. Impaired skin immune system occurring early in HIV disease is believed to be responsible for the frequent occurrence of both infectious and non-infectious skin diseases even before the development of full blown HIV infection.…”

Section: Introductionmentioning

confidence: 99%

Dermatological manifestations in human immunodeficiency virus infected patients: Morphological spectrum with CD4 correlation

Chawhan

Bhat

Solanke

2013

Indian J Sex Transm Dis

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Background:More than 90% of human immunodeficiency virus (HIV) infected patients develop skin lesions at some time throughout the course of the disease. Several skin diseases have proved to be sensitive and useful indicators of progression of HIV infection. Although these conditions may be seen in general healthy population, their occurrence in patients with acquired immunodeficiency syndrome is often atypical, more severe and explosive.Aims:The present study was carried out to categorize the skin lesions by histopathology using punch biopsy or cytology when feasible in HIV infected patients and to see the correlation for various skin lesions with CD4 counts.Materials and Methods:In total 110 known HIV positive patients with the symptomatic skin lesions, cytology and punch biopsy was correlated with CD4 counts.Results:Maximum patients were between 31 and 40 years. 53 (48.18%) patients had infectious and 37 (34.55%) patients had non-infectious lesions. Out of 110 patients, CD4 counts were available in 70 patients. The spectrum of various non-infectious and infectious lesions such as viral, bacterial, fungal, protozoa and their association with CD4 counts is discussed.Conclusions:CD4 counts below 200 were associated with the maximum infectious lesions, whereas CD4 counts more than 350 showed more of the non-infectious lesions. Most common infectious lesion was Molluscum contagiosum. The most common non-infectious lesion was pruritic papular eruptions.

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“…One or other of these conditions is seen in 23± 30% of HIV-positive individuals 14 . They may result from chronic illness, malnutrition, or the underlying immunological de® cit.…”

Section: Xerosis/acquired Icthyosismentioning

confidence: 99%

The management of HIV-related skin disease Part II: Neoplasms and inflammatory disorders

Osborne

Taylor

Fuller³

2003

Int J STD AIDS

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Prevalence and clinical spectrum of skin disease in patients infected with human immunodeficiency virus

Cited by 59 publications

References 0 publications

Dermatological manifestations in HIV-infected patients at a tertiary care hospital in a tribal (Bastar) region of Chhattisgarh, India

Dermatological manifestations in HIV-infected patients at a tertiary care hospital in a tribal (Bastar) region of Chhattisgarh, India

Dermatological manifestations in human immunodeficiency virus infected patients: Morphological spectrum with CD4 correlation

The management of HIV-related skin disease Part II: Neoplasms and inflammatory disorders

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