Prevalence and clinical predictors of drug‐resistant tuberculosis in three clinical settings in <scp>C</scp>alabar, <scp>N</scp>igeria

Otu, Akaninyene; Umoh, Victor A.; Habib, Abdulrazak; Ansa, Victor

doi:10.1111/crj.12065

Cited by 6 publications

(2 citation statements)

References 17 publications

(18 reference statements)

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“…In Lagos, for instance, 32 % of all new patients with their first ever episode of TB were already presenting with widely circulating MDR isolates. Our findings support previous publications from Nigeria [8–12] and Burkina Faso [13, 14]; however, variations in the respective MDR prevalence estimates of these publications are considerable, due to differences in sampling strategy, collection time points and location, making an overall comparison difficult. Burkina Faso, Nigeria and Niger were the only WANETAM countries that previously reported XDR isolates [3, 15].…”

Section: Discussionsupporting

confidence: 86%

The emerging threat of pre-extensively drug-resistant tuberculosis in West Africa: preparing for large-scale tuberculosis research and drug resistance surveillance

Gehre

Otu

Kendall

et al. 2016

BMC Med

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BackgroundDrug-resistant tuberculosis (TB) is a global public health problem. Adequate management requires baseline drug-resistance prevalence data. In West Africa, due to a poor laboratory infrastructure and inadequate capacity, such data are scarce. Therefore, the true extent of drug-resistant TB was hitherto undetermined. In 2008, a new research network, the West African Network of Excellence for Tuberculosis, AIDS and Malaria (WANETAM), was founded, comprising nine study sites from eight West African countries (Burkina Faso, The Gambia, Ghana, Guinea-Bissau, Mali, Nigeria, Senegal and Togo). The goal was to establish Good Clinical Laboratory Practice (GCLP) principles and build capacity in standardised smear microscopy and mycobacterial culture across partnering laboratories to generate the first comprehensive West African drug-resistance data.MethodsFollowing GCLP and laboratory training sessions, TB isolates were collected at sentinel referral sites between 2009–2013 and tested for first- and second-line drug resistance.ResultsFrom the analysis of 974 isolates, an unexpectedly high prevalence of multi-drug-resistant (MDR) strains was found in new (6 %) and retreatment patients (35 %) across all sentinel sites, with the highest prevalence amongst retreatment patients in Bamako, Mali (59 %) and the two Nigerian sites in Ibadan and Lagos (39 % and 66 %). In Lagos, MDR is already spreading actively amongst 32 % of new patients. Pre-extensively drug-resistant (pre-XDR) isolates are present in all sites, with Ghana showing the highest proportion (35 % of MDR). In Ghana and Togo, pre-XDR isolates are circulating amongst new patients.ConclusionsWest African drug-resistance prevalence poses a previously underestimated, yet serious public health threat, and our estimates obtained differ significantly from previous World Health Organisation (WHO) estimates. Therefore, our data are reshaping current concepts and are essential in informing WHO and public health strategists to implement urgently needed surveillance and control interventions in West Africa.

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Section: Discussionsupporting

confidence: 86%

The emerging threat of pre-extensively drug-resistant tuberculosis in West Africa: preparing for large-scale tuberculosis research and drug resistance surveillance

Gehre

Otu

Kendall

et al. 2016

BMC Med

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“…En este contexto, mundialmente se han llevado a cabo una serie de estudios utilizando la clínica, la radiología, los exámenes de laboratorio y hasta la inmunogenética, con el objetivo de establecer factores predictores de TB-MDR, entre cuyos resultados destacan la asociación con infección por VIH, la presencia de adenopatías hiliares o mediastinales en la radiografía de tórax y la ausencia de infiltrados en la radiografía de tórax (7) ; del mismo modo otros factores asociados son ser joven, abandonar el tratamiento y la presencia de lesiones cavitarias en la radiografía de tórax (8) ; mientras que en el Perú otro estudio encontró que el contacto con un paciente con TB-MDR dentro de la familia, un examen pulmonar anormal y el patrón cavitario en las radiografías de tórax son factores relacionados a presentar TB-MDR (6) .…”

Section: Introductionunclassified

Predictores clínicos de tuberculosis multidrogorresistente en pacientes con tuberculosis pulmonar en Huánuco, Perú. 2010-2015

Valdivia-Gómez¹,

Zavala-Lazo²,

Dámaso-Mata³

et al. 2020

RFMH

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TB Control in Nigeria

Gidado¹,

Obasanya²,

Habib

et al. 2017

Handbook of Global Tuberculosis Control

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Prevalence and clinical predictors of drug‐resistant tuberculosis in three clinical settings in Calabar, Nigeria

Abstract: Thus, risk stratification of TB patients is advocated in clinical settings where diagnostic facilities for drug-resistant TB are scarce using the identified predictors. This group will benefit from close monitoring and early drug susceptibility testing.

Cited by 6 publications

References 17 publications

The emerging threat of pre-extensively drug-resistant tuberculosis in West Africa: preparing for large-scale tuberculosis research and drug resistance surveillance

The emerging threat of pre-extensively drug-resistant tuberculosis in West Africa: preparing for large-scale tuberculosis research and drug resistance surveillance

Predictores clínicos de tuberculosis multidrogorresistente en pacientes con tuberculosis pulmonar en Huánuco, Perú. 2010-2015

TB Control in Nigeria

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