2016
DOI: 10.2147/ndt.s100846
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Abstract: BackgroundUncertainty exists regarding the prevalence and clinical features associated with the practice of polypharmacy in bipolar disorder (BD), warranting a systematic review on the matter.MethodsThree authors independently searched major electronic databases from inception till September 2015. Articles were included that reported either qualitative or quantitative data about the prevalence and clinical features associated with polypharmacy in adult cases of BD.ResultsThe operative definitions of polypharma… Show more

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Cited by 77 publications
(54 citation statements)
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“…30 The results of another systematic review that assessed prevalence and associated clinical signs through variations in polypharmacy definition and mood variation in adults with bipolar disorder showed a prevalence that varied between 85% and 36% depending on whether the study used a "permissive" (2 drugs simultaneously) or more "conservative" (4 and more) definition. 31 It is also difficult to estimate the cost of polypharmacy and its burden on health systems. For instance, in Great Britain, we can have the total number of drugs dispensed and its evolution (1.08 billion ≈ 19.9 drugs/person in 2015 Vs. 962 million ≈183 drugs/per cent in 2011 32 ); in USA the cost associated with the management of falls among people over 65 years old (£6million/day or £2.3 billion/ year for the NHS in 2010 33 has been estimated in $20 billion in 2006 34 ).…”
Section: No Standard Definition: An Obstacle To Measuring Outcomesmentioning
confidence: 99%
“…30 The results of another systematic review that assessed prevalence and associated clinical signs through variations in polypharmacy definition and mood variation in adults with bipolar disorder showed a prevalence that varied between 85% and 36% depending on whether the study used a "permissive" (2 drugs simultaneously) or more "conservative" (4 and more) definition. 31 It is also difficult to estimate the cost of polypharmacy and its burden on health systems. For instance, in Great Britain, we can have the total number of drugs dispensed and its evolution (1.08 billion ≈ 19.9 drugs/person in 2015 Vs. 962 million ≈183 drugs/per cent in 2011 32 ); in USA the cost associated with the management of falls among people over 65 years old (£6million/day or £2.3 billion/ year for the NHS in 2010 33 has been estimated in $20 billion in 2006 34 ).…”
Section: No Standard Definition: An Obstacle To Measuring Outcomesmentioning
confidence: 99%
“…Beyond study design, additional issues, including the (protective?) roles of adjunctive lithium, valproate/carbamazepine and SGAs, should be discussed, since psychotropic polypharmacy is common among BD patients . Previous studies have demonstrated the protective role of lithium against a mood switch from mania to depression in BD, and have been able to exclude, to a large extent, the possibility of a risk of a manic switch in BD patients receiving antidepressants augmented with mood stabilizers .…”
Section: Discussionmentioning
confidence: 99%
“…Specifically, evidence sometimes suggests benefits of antidepressant use in patients with BD, whereas other reports cast significant doubts on both the efficacy and tolerability of antidepressants in this patient population …”
Section: Introductionmentioning
confidence: 99%
“…To make the situation worse, there is a widespread increasing trend of polypharmacy practice in bipolar disorders,3 with almost half of patients receiving at least three concurrent medications 4. To be specific, coadministration of lithium and neuroleptic drugs has been an ongoing issue as this was found to cause neurotoxicity.…”
Section: Discussionmentioning
confidence: 99%