Prevalence and Clinical Differentiation of Dengue Fever in Children in Northern India

Kumar, Rashmi; Tripathi, Piyush; Tripathi, Shweta; Kanodia, Alok; Pant, S.; Venkatesh, Vimala

doi:10.1007/s15010-008-7172-6

Cited by 23 publications

(25 citation statements)

References 15 publications

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“…However, apart from rhinorrhea, which lacked adequate sensitivity and specificity, we found that all other variables were specific (>70%) but not sensitive enough in distinguishing influenza from OFI. This is not surprising as more than 60% of OFI cases included in this series were individuals with pharyngitis or bronchitis (Table 4), another viral infection commonly encountered in the ER [38]. The information of this study are most helpful for clinicians to facilitate diagnosis of influenza during periods of high influenza activity in non-dengue endemic setting.…”

Section: Discussionmentioning

confidence: 81%

Use of simple clinical and laboratory predictors to differentiate influenza from dengue and other febrile illnesses in the emergency room

et al. 2014

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BackgroundClinical differentiation of influenza from dengue and other febrile illnesses (OFI) is difficult, and available rapid diagnostic tests have limited sensitivity.MethodsWe conducted a retrospective study to compare clinical and laboratory findings between (i) influenza and dengue and (ii) influenza and OFI.ResultsOf 849 enrolled patients, the mean time between illness onset and hospital presentation was 1.7, 3.7, and 3 days for influenza, dengue, and OFI, respectively. Among pediatric patients (≤18 years) (445 influenza, 24 dengue, and 130 OFI), we identified absence of rashes, no leukopenia, and no marked thrombocytopenia (platelet counts <100 × 109 cells/L) as predictors to distinguish influenza from dengue, whereas rhinorrhea, malaise, sore throat, and mild thrombocytopenia (platelet counts 100-149 × 109/L) were predictors that differentiated influenza from OFI. Among adults (>18 years) (81 influenza, 124 dengue, and 45 OFI), no leukopenia and no marked thrombocytopenia distinguished influenza from dengue, while rhinorrhea and malaise differentiated influenza from OFI. A diagnostic algorithm developed to distinguish influenza from dengue using rash, leukopenia, and marked thrombocytopenia showed >90% sensitivity to identify influenza in pediatric patients.ConclusionsThis study identified simple clinical and laboratory parameters that can assist clinicians to distinguish influenza from dengue and OFI. These findings may help clinicians diagnose influenza and facilitate appropriate management of affected patients, particularly in resource-poor settings.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-014-0623-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 81%

Use of simple clinical and laboratory predictors to differentiate influenza from dengue and other febrile illnesses in the emergency room

et al. 2014

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“…Another study results carried out in United Kingdom had shown that DVI can present as undifferentiated fever (39). A study carried out on children between 6 months to 12 years in Lucknow, India has shown that DVI can cause undifferentiated febrile illness (40). The Cuban Government had declared two Dengue outbreaks showing the presence of febrile illness as initial presentation in 3.2% of the total diagnosed cases (41).…”

Section: And Puomentioning

confidence: 99%

Dengue Viral Infection and Necessity for Screening Patients Having Pyrexia of Unknown Origin

Zafar¹,

Bukhari²,

Humayoun³

et al. 2017

Ulutas Med J

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Dengue Viral Infection (DVI) is an emerging global health problem infecting about 50-100 million people annually world wide. More than 2.5 million people have dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Aedesaegypti is the principal vector for disease transmission while humans are the main reservoir. The clinical manifestations range from self limited Dengue fever (DF) to complicated and fatal outcomes, DHF and DSS. DF is prevalent in more than 100 countries of the world. More than 2.5 billion people of the World ' s population are residents of Dengue endemic area. According to one reported study the prevalence of DF in Pakistan is 29%. Similarly one study result carried out in India has shown 78% prevalence of DF. In Mexico the one published seroprevalence study showed 79.6% prevalence of DF. A review/analysis report of Gynecological and Obstetrical survey from 30 published studies has shown 64% transmission rate of DF from a mother to a child. The study results carried out in Jamaica has shown an increased in the prevalence of DF in seen in less than 1year and more than 60 years. The mortality rate with DHF is 33%. While in less than 15 year of it is 5%. This can be only reduced with early/ accurate diagnosis and the prompt management of the condition. Absence of specific vaccine and anti viral is responsible for making this infection as a global health problem. The US government has spent 15 million US dollars for the establishment and discovery of specific DF treatment. The study carried out in India has shown the median cost for treatment per patient about 432.2 US dollars. It is 4 times in case of private health sectors. The proposed review article will highlight the incidence of dengue infection in patients having PUO (pyrexia of unknown origin). It will be a guide for the clinicians to consider DVI in their list of differential diagnosis of PUO. Moreover it will be helpful in establishing the screening policies for DVI in PUO. The resultant of all of this will improve the life quality of PUO sufferers. It will be useful to reduce the increased financial burden due to PUO missed diagnosis and management in under developed countries like one of ours.

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“…The spectrum of dengue disease includes -Asymptomatic cases, dengue fever, dengue hemorrhagic fever and dengue shock syndrome. Infection can be life threatening, usually when caused by secondary infection (a dengue infection in a host that has previously been infected by a dengue virus, with heterologous virus serotype) Kumar et al, (2008). The incubation period of dengue viral infection varies from 5 to 10 days, Viremia occurs about two days prior to clinical manifestations and lasts for course of 5 to 6 days of illness.…”

mentioning

confidence: 99%

A Study on the Laboratory Profiles in Dengue Viral Infection

Sirigadha¹,

Khaleel²

2017

Int.J.Curr.Microbiol.App.Sci

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Prevalence and Clinical Differentiation of Dengue Fever in Children in Northern India

Cited by 23 publications

References 15 publications

Use of simple clinical and laboratory predictors to differentiate influenza from dengue and other febrile illnesses in the emergency room

Use of simple clinical and laboratory predictors to differentiate influenza from dengue and other febrile illnesses in the emergency room

Dengue Viral Infection and Necessity for Screening Patients Having Pyrexia of Unknown Origin

A Study on the Laboratory Profiles in Dengue Viral Infection

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