Prevalence and characteristics of anti-single-stranded DNA antibodies in localized scleroderma. Comparison with systemic lupus erythematosus

Serum Autoantibodies and Their Clinical Associations in Patients with Childhood- and Adult-Onset Linear Scleroderma. A Single-Center Study

“…Takehara, et al first observed the presence of ANA in patients with LS in 1983, using cultured human cell substrates 20 . Their findings were confirmed by others, with the prevalence of ANA in LS patients ranging from 46% to 63% using similar methods [8][9][10][11][13][14][15]17,18 . Our LiScl-only cohort was found to have ANA more frequently than those reported from Japan (68% vs 42%-50%, respectively).…”

“…Although the pathogenesis of LS remains unclear, immunologic abnormalities are common, as evidenced by the presence of lymphocytes and plasma cells in skin lesions. Serum autoantibodies, including antinuclear antibodies (ANA; 46%-63% using HEp-2 cells as substrate), anti-single-stranded DNA (anti-ssDNA), antihistone antibody (AHA), antitopoisomerase IIa, anti-nucleosome antibodies, and rheumatoid factor are frequently detected [8][9][10][11][12][13][14][15][16][17][18] . These reports included all subtypes of LS and most had small numbers of patients.…”

Progressive facial hemiatrophy - A case series

“…[10] Some other reports also showed positivity to anti-DS-DNA. [1213] In our series only one patient had a positive Anti-Nuclear-Antibody (ANA) screen, however, none of the patients showed specific positivity in an ANA profile test, which included — anti-single-stranded DNA (anti-ssDNA), anti-double-stranded DNA (anti-dsDNA), anticentromere (ACA), anti-SCL-70, anti-Jo/La, and anti-u1RNP.…”

Parry–Romberg syndrome in association with anti‐dsDNA antibodies: a case report

“…Ruffatti et al. reported 52 patients with localized scleroderma and revealed a significant prevalence of anti‐ssDNA in morphea 10 . But the autoantibody profile of PRS was different from that in localized scleroderma in one study.…”