Prevalence and burden of comorbidities in Chronic Obstructive Pulmonary Disease

Corlăteanu, Alexandru; Covanţev, Serghei; Mathioudakis, Alexander G.; Botnaru, Victor; Siafakas, Nikolaos M.

doi:10.1016/j.resinv.2016.07.001

Cited by 68 publications

(55 citation statements)

References 88 publications

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“…1 2 6 Patients experiencing frequent exacerbations have worse quality of life, 7 accelerated lung function decline 8 and are at increased risk of future exacerbations, myocardial infarctions, cerebrovascular events and mortality. [9][10][11][12] With a definition, diagnostic criteria and treatment strategies that remain insufficient and unchanged for decades, 1-3 COPD exacerbations represent a major, unaddressed global health need. More specifically, their definition and diagnostic criteria are solely based on clinical characteristics, which lack specificity.…”

Section: Introductionmentioning

confidence: 99%

Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits

Mathioudakis

Janssens

Sivapalan

et al. 2020

Thorax

109

119

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Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with a significant mortality, health and economic burden. Their diagnosis, assessment and management remain suboptimal and unchanged for decades. Recent clinical and translational studies revealed that the significant heterogeneity in mechanisms and outcomes of exacerbations could be resolved by grouping them etiologically. This is anticipated to lead to a better understanding of the biological processes that underlie each type of exacerbation and to allow the introduction of precision medicine interventions that could improve outcomes. This review summarises novel data on the diagnosis, phenotyping, targeted treatment and prevention of COPD exacerbations.

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Section: Introductionmentioning

confidence: 99%

Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits

Mathioudakis

Janssens

Sivapalan

et al. 2020

Thorax

109

119

View full text Add to dashboard Cite

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“…Diabetes 13 , 14 , obesity 15 , and dyslipidemia 16 , 17 were also recognized as the common occurrences of multimorbidity with CVD. Besides, some other diseases such as chronic respiratory disease 18 , liver disease 19 and depression 20 had been studied as potential occurrences of multimorbidity with CVD as well.…”

Section: Introductionmentioning

confidence: 99%

Multimorbidity Analysis According to Sex and Age towards Cardiovascular Diseases of Adults in Northeast China

Jin

Guo

Dou

et al. 2018

Sci Rep

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Non-communicable diseases (NCDs) are great challenges in public health, where cardiovascular diseases (CVD) accounted for the large part of mortality that caused by NCDs. Multimorbidity is very common in NCDs especially in CVD, thus multimorbidity could make NCDs worse and bring heavy economic burden. This study aimed to explore the multimorbidity among adults, especially the important role of CVD that played in the entire multimorbidity networks. A total of 21435 participants aged 18–79 years old were recruited in Jilin province in 2012. Weighted networks were adopted to present the complex relationships of multimorbidity, and Charlson Comorbidity Index (CCI) was used to evaluate the burden of multimorbidity. The prevalence of CVD was 14.97%, where the prevalence in females was higher than that in males (P < 0.001), and the prevalences of CVD increased with age (from 2.22% to 38.38%). The prevalence of multimorbidity with CVD was 96.17%, and CVD could worsen the burden of multimorbidity. Multimorbidity and multimorbidity with CVD were more marked in females than those in males. And the prevalence of multimorbidity was the highest in the middle-age, while the prevalence of multimorbidity with CVD was the highest in the old population.

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“…Finally, comorbidities could impact health status and its MCIDs [17]. Patients with COPD experience a variety of comorbidities [74]. MCIDs for improvement were larger for RCP patients with fewer comorbidities and smaller in deterioration for this group.…”

Section: Gender Age and Comorbiditiesmentioning

confidence: 99%

Baseline health status and setting impacted minimal clinically important differences in COPD: an exploratory study

Alma

Jong

Jelusic

et al. 2019

Journal of Clinical Epidemiology

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Objectives: Minimal clinically important differences (MCIDs) are used as fixed numbers in the interpretation of clinical trials. Little is known about its dynamics. This study aims to explore the impact of baseline score, study setting, and patient characteristics on health status MCIDs in chronic obstructive pulmonary disease (COPD). Study Design and Setting: Baseline and follow-up data on the COPD Assessment Test (CAT), Clinical COPD Questionnaire (CCQ), and St. George's Respiratory Questionnaire (SGRQ) were retrospectively analyzed from pulmonary rehabilitation (PR) and routine clinical practice (RCP). Anchor-and distribution-based MCID estimates were calculated and tested between settings, gender, age, Global initiative Funding: The main RIMTCORE trial (#DRKS00004609) was funded by the Deutsche Rentenversicherung, Germany. The Dutch observational study on COPD health status in routine clinical practice (MCID study) as well as the current combined retrospective analysis of both studies received financial support from the Junior Scientific Masterclass (JSM) as part of the

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Prevalence and burden of comorbidities in Chronic Obstructive Pulmonary Disease

Cited by 68 publications

References 88 publications

Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits

Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits

Multimorbidity Analysis According to Sex and Age towards Cardiovascular Diseases of Adults in Northeast China

Baseline health status and setting impacted minimal clinically important differences in COPD: an exploratory study

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