1994
DOI: 10.1016/0952-8180(94)90087-6
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Abstract: This study suggests that benzodiazepine pretreatment is frequently, but not always, effective in preventing opioid-induced muscle rigidity.

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Cited by 33 publications
(14 citation statements)
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“…23,24 Moreover, alprazolam given 60 min prior to induction of anesthesia may also have contributed to minimizing the occurrence of muscle rigidity, since premedication with benzodiazepine is effective in preventing opioid-induced muscle rigidity. 25 Hemodynamic tolerance was similar and acceptable in the four groups of our study. The maximum decrease in mean values of HR and MAP was less than 30%, and there was no significant increase in the requirement of ephedrine administration across the four groups.…”
Section: Discussionsupporting
confidence: 62%
“…23,24 Moreover, alprazolam given 60 min prior to induction of anesthesia may also have contributed to minimizing the occurrence of muscle rigidity, since premedication with benzodiazepine is effective in preventing opioid-induced muscle rigidity. 25 Hemodynamic tolerance was similar and acceptable in the four groups of our study. The maximum decrease in mean values of HR and MAP was less than 30%, and there was no significant increase in the requirement of ephedrine administration across the four groups.…”
Section: Discussionsupporting
confidence: 62%
“…This is in contrast to a previous study in which the authors reported an incidence of muscle rigidity of 7% when administering an infusion of remifentanil 1 mg.kg ¹1 .min ¹1 followed by propofol 0.5-1 mg.kg ¹1 [14]. The higher dose of propofol (2 mg.kg ¹1 ) administered before the bolus of remifentanil may prevent or attenuate opioid-induced muscle rigidity as shown with a combination of benzodiazepines and barbiturates [15,16].…”
Section: R Alexander Et Al • Remifentanil Vs Alfentanil For Intubationcontrasting
confidence: 72%
“…24 Further, pretreatment with a benzodiazepine is effective in preventing opioid-induced muscle rigidity. 26 With regard to cardiovascular variables, there was a marked similarity between the changes caused by the different doses of remifentanil both after induction and intubation. Indeed, it has been shown that after remifentanil the decreases in arterial pressure and heart rate of about 20% were independent of the dose from 2 to 30 µg·kg -1 .…”
Section: Discussionmentioning
confidence: 92%