Pretreatment with long-wave ultraviolet light inhibits ultraviolet-induced skin tumor development in hairless mice

Bech-Thomsen, Niels

doi:10.1001/archderm.124.8.1215

Cited by 7 publications

(3 citation statements)

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“…It has been shown that UVA protected mice from UVB-induced erythema and sunburn cell formation, 34 as well as from melanogenesis and photocarcinogenesis. 35 Chung and Youn 36 reported that UVA irradiation suppressed the stimulatory effect of UVB on interleukin-1 in cultured human keratinocytes. In future studies, irradiations with UVA and UVB sequentially and simultaneously should address the question of possible UV interactions.…”

Section: Discussionmentioning

confidence: 99%

Differential expression of melanoma-associated growth factors in keratinocytes and fibroblasts by ultraviolet A and ultraviolet B radiation

et al. 2005

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UVA and UVB can stimulate and inhibit the production of growth factors for melanocytes in keratinocytes and fibroblasts dependent on the cell type and wavelength. We show for the first time that UVA and UVB can activate bFGF, HGF and TGF-beta1 in fibroblasts, while bFGF was the most inducible factor both in fibroblasts and in keratinocytes. The induction of bFGF and HGF in fibroblasts by UVA suggests that stroma cells in the dermis may be involved in the UV activation of melanocytes via paracrine ways and thus promote melanoma development.

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Section: Discussionmentioning

confidence: 99%

Differential expression of melanoma-associated growth factors in keratinocytes and fibroblasts by ultraviolet A and ultraviolet B radiation

et al. 2005

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“…Ultraviolet radiation is a complete carcinogen causing non-melanoma skin cancer (19)(20)(21). Interaction between tacrolimus and UVR is clinically relevant as tacrolimus ointment is often used on sun-exposed areas.…”

Section: Introductionmentioning

confidence: 99%

Topical tacrolimus in combination with simulated solar radiation does not enhance photocarcinogenesis in hairless mice

Lerche

Philipsen

Poulsen

et al. 2007

Experimental Dermatology

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Numerous studies have demonstrated the utility of topical tacrolimus ointment in atopic dermatitis. However, there is a concern that local immunosuppression by calcineurin inhibitors may enhance dermal photocarcinogenesis and carcinogenesis. Therefore, we investigated the influence of topical tacrolimus ointment on squamous cell carcinoma formation in hairless female C3.Cg/TifBomTac immunocompetent mice exposed to solar simulated radiation (SSR). In a first experiment, mice (n = 200) had tacrolimus applied on their dorsal skin three times weekly followed by SSR (2, 4 or 6 standard erythema doses, SED) 3-4 h later. Tacrolimus did not reduce the time to tumor development and in the group receiving 4 SED it even had a protective effect (156 days vs 170 days, P = 0.008). In a second experiment, mice (n = 50) were irradiated with 6 SED three times weekly for 3 months and subsequently treated five times weekly with topical tacrolimus to mimic the use of tacrolimus on sun-damaged skin. The median time to the first skin tumor was 234 days in SSR + tacrolimus group compared with 227 days in the only SSR-irradiated group (P = 0.160). In a third experiment, mice (n = 25) had tacrolimus applied on their dorsal skin every day for 1 month, thereafter the group was irradiated with 4 SED three times weekly. The median time to the first skin tumor was 142 days in tacrolimus + SSR group compared with 156 days in the only SSR-irradiated group from experiment 1 (P = 0.363). We conclude that tacrolimus ointment does not accelerate photocarcinogenesis or induce any dermal carcinogenicity in hairless mice.

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“…Effect of UVA on the UVB-induced immune suppression is also important. Previous reports suggested a protective role of UVA-induced tan (48). However, more recent studies suggest that UVA can suppress the immune response (49) and increase photocarcinogenesis (50).…”

Section: Effect Of Uvamentioning

confidence: 97%

UV‐induced immune suppression and sunscreen

Gil

Kim

2000

Photoderm Photoimm Photomed

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Sun protection factor (SPF) that measures sunscreen protection against erythema and edema may not be enough to measure a sunscreen's activity against many other biologic reactions induced by ultraviolet radiation (UV). It may be better to evaluate sunscreen efficacy using various tools including immune protection factor (IPF), mutation protection factor (MPF) and protection against photocarcinogenesis. In terms of immune protection, sunscreens protected against UV-induced immune suppression significantly. But protection in some cases was partial and often the IPF of sunscreens were less than the SPF. IPF may differ with various immunological endpoints, and it T he sun emits a wide range of ultraviolet (UV) radiation. All of the harmful UVC (200-280 nm) and most of UVB (280-320 nm) is absorbed by the stratospheric ozone layer. Stratospheric ozone does not affect UVA (320-400 nm) transmission. As the stratospheric ozone layer is depleted (1) the amount of harmful shortwave UV reaching the earth's surface will increase. On the other hand, chances of UV exposure by increased outdoor activity and imprudent use of sun tanning machines increased the risks of unwanted UV effects, such as sunburn, photoaging, skin cancer induction and immune suppression (2). Solar UV is the most prominent cause of skin cancer, a cancer that is the most common cancer found in Caucasian populations. During photocarcinogenesis, UV works as both an initiator by directly damaging DNA and as a promotor by suppressing immunologic rejection (3).Sunscreen use has been promoted as one way to prevent these harmful consequences of UV exposure. The ability of a sunscreen to protect against erythema, the so-called SPF, although well characterized may not be an adequate measure of a sunscreen's ability to protect against other biological endpoints, particularly immune suppression (4). Although there are many examples in the scientific literature regarding sunscreen protection against UV-in-101 may be better to use a couple of different assays to measure sunscreen protection more objectively. Sunscreen use protects against most UV-induced nonmelanoma skin cancers and actinic keratoses but its activity against melanoma is not clear. More studies with broad-spectrum stable sunscreens and better models for the investigation of malignant melanoma are required.

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Pretreatment with long-wave ultraviolet light inhibits ultraviolet-induced skin tumor development in hairless mice

Cited by 7 publications

References 0 publications

Differential expression of melanoma-associated growth factors in keratinocytes and fibroblasts by ultraviolet A and ultraviolet B radiation

Differential expression of melanoma-associated growth factors in keratinocytes and fibroblasts by ultraviolet A and ultraviolet B radiation

Topical tacrolimus in combination with simulated solar radiation does not enhance photocarcinogenesis in hairless mice

UV‐induced immune suppression and sunscreen

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