Pretreatment with arginine preserves intestinal barrier integrity and reduces bacterial translocation in mice

Abstract

Arginine was able to preserve barrier integrity, thus reducing BT.

Arginine reduces bacterial invasion in rats with head injury

“…For the first time to our knowledge, using an innovative noninvasive method directly reflecting bacterial invasion, we show that arginine is able to reduce it in rats with head injury. Interestingly, this effect seems to be independent of any improvement in nutritional status, in agreement with two recent experimental studies (13,14). None of the nutritional parameters evaluated other than its plasma concentration (standard group: 100 Ϯ 12 vs. arginine group: 220 Ϯ 11 mol/L; p Ͻ .05), namely body and organ weight, tissue protein content, nitrogen balance, and fibrinogen, was influenced by arginine supply (see complementary data).…”

Morphology of the Intestinal Barrier in Different Physiological and Pathological Conditions

“…There was also a discrete increase in the cellularity of lamina propria. In addition to that, epithelial reactive changes, superficial erosions, edema, and enlargement of the intestinal villi were observed under light microscope [24].…”

“…Animal models of intestinal obstruction, treated with arginine presented preservation of the tissue structure. The villous epithelium was preserved and only discrete edema and enlargement were present at lamina propria [24].…”

L-Arginine Pretreatment Reduces Intestinal Mucositis as Induced by 5-FU in Mice

“…It is considered a conditionally essential amino acid during catabolic states (16), and it participates in the synthesis of nitric oxide, urea, ornithine, citrulline, creatine, agmatine, glutamate, proline, and polyamines (17). The beneficial effects of L-arginine on the maintenance and recovery of the intestinal mucosa (18)(19)(20) in addition to improved intestinal permeability (21,22) have been reported. We hypothesized that pretreatment with L-arginine may reduce intestinal mucositis induced by administration of 5-FU.…”