2018
DOI: 10.18632/aging.101585
View full text |Buy / Rent full text
|
|
et al.

## Abstract:Chemoradiotherapy combined with surgical resection is the standard treatment for locally advanced rectal cancer, but not all the patients respond to neoadjuvant treatment. Transforming acidic coiled-coil protein-3 (TACC3) is frequently aberrantly expressed in rectal cancer tissue. In this study, we investigated whether TACC3 could serve as a biomarker predictive of the efficacy of chemoradiotherapy. In all, 152 rectal cancer patients with tumor tissue collected at biopsy and set aside before treatment were enr… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
7
0

Year Published

2019
2019
2022
2022

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

##### Cited by 5 publications
(7 citation statements)
##### References 41 publications
(38 reference statements)
0
7
0
Order By: Relevance
“…Zhi-Rui Lin et al found that the up-regulation of TACC3 was positively correlated with the tumor aggressiveness, grade, T stage, and progression in bladder cancer patients ( Lin et al, 2018 ). The expression of TACC3 may predict the radiosensitivity and prognosis of locally advanced rectal cancer ( Ma et al, 2018 ). In addition, TACC3 can be used as a biomarker with a potential role in breast cancer detection and for the prediction of clinical outcomes ( Campo and Breuer, 2018 ).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Zhi-Rui Lin et al found that the up-regulation of TACC3 was positively correlated with the tumor aggressiveness, grade, T stage, and progression in bladder cancer patients ( Lin et al, 2018 ). The expression of TACC3 may predict the radiosensitivity and prognosis of locally advanced rectal cancer ( Ma et al, 2018 ). In addition, TACC3 can be used as a biomarker with a potential role in breast cancer detection and for the prediction of clinical outcomes ( Campo and Breuer, 2018 ).…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, previous studies demonstrated that TACC3 deficiency inhibited the epithelial-mesenchymal transition phenotype by activating the PI3K/Akt and ERK signaling pathways ( Ha et al, 2013 ). Based on these studies, it seems that TACC3 may promote tumor progression by increasing cell proliferation, cancer stem cell population, and cancer cell migration ( Ma et al, 2018 ). However, the potential role of TACC3 in breast cancer is still largely unknown.…”
Section: Introductionmentioning
confidence: 99%
“…TACC3 overexpression is related to chemoradiotherapy resistance in patients with locally advanced rectal cancer [41]. Inhibition of TACC3 in breast cancer induced apoptotic cell death [42].…”
Section: Discussionmentioning
confidence: 99%
“…Herein, we focus mainly on newly identified proteins from biopsies and blood which were mainly listed in Table 4 (Ref. [73][74][75][76][77][78][79][80][81][82][83][84]).…”
Section: Cellular Protein Biomarkersmentioning
confidence: 99%
“…DEK may be related to the pro-apoptotic factor P38 [76]. Expression of the transforming acidic coiled-coil protein-3 in RC patients was found to negatively correlate with sensitivity to nCRT (RR = 2.23, 95% CI: 1.44-3.45; p = 0.001), resulting in less pCR (p = 0.001) [77]. Yan et al [45] reported that low expression of RAD18 (an E3 ubiquitin-linked enzyme) in pre-nCRT biopsies of RC patients correlated to better clinical outcomes after treatment.…”
Section: Cellular Protein Biomarkersmentioning
confidence: 99%