2018
DOI: 10.18632/aging.101585
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Abstract: Chemoradiotherapy combined with surgical resection is the standard treatment for locally advanced rectal cancer, but not all the patients respond to neoadjuvant treatment. Transforming acidic coiled-coil protein-3 (TACC3) is frequently aberrantly expressed in rectal cancer tissue. In this study, we investigated whether TACC3 could serve as a biomarker predictive of the efficacy of chemoradiotherapy. In all, 152 rectal cancer patients with tumor tissue collected at biopsy and set aside before treatment were enr… Show more

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Cited by 5 publications
(7 citation statements)
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References 41 publications
(38 reference statements)
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“…Zhi-Rui Lin et al found that the up-regulation of TACC3 was positively correlated with the tumor aggressiveness, grade, T stage, and progression in bladder cancer patients ( Lin et al, 2018 ). The expression of TACC3 may predict the radiosensitivity and prognosis of locally advanced rectal cancer ( Ma et al, 2018 ). In addition, TACC3 can be used as a biomarker with a potential role in breast cancer detection and for the prediction of clinical outcomes ( Campo and Breuer, 2018 ).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Zhi-Rui Lin et al found that the up-regulation of TACC3 was positively correlated with the tumor aggressiveness, grade, T stage, and progression in bladder cancer patients ( Lin et al, 2018 ). The expression of TACC3 may predict the radiosensitivity and prognosis of locally advanced rectal cancer ( Ma et al, 2018 ). In addition, TACC3 can be used as a biomarker with a potential role in breast cancer detection and for the prediction of clinical outcomes ( Campo and Breuer, 2018 ).…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, previous studies demonstrated that TACC3 deficiency inhibited the epithelial-mesenchymal transition phenotype by activating the PI3K/Akt and ERK signaling pathways ( Ha et al, 2013 ). Based on these studies, it seems that TACC3 may promote tumor progression by increasing cell proliferation, cancer stem cell population, and cancer cell migration ( Ma et al, 2018 ). However, the potential role of TACC3 in breast cancer is still largely unknown.…”
Section: Introductionmentioning
confidence: 99%
“…TACC3 overexpression is related to chemoradiotherapy resistance in patients with locally advanced rectal cancer [41]. Inhibition of TACC3 in breast cancer induced apoptotic cell death [42].…”
Section: Discussionmentioning
confidence: 99%
“…Herein, we focus mainly on newly identified proteins from biopsies and blood which were mainly listed in Table 4 (Ref. [73][74][75][76][77][78][79][80][81][82][83][84]).…”
Section: Cellular Protein Biomarkersmentioning
confidence: 99%
“…DEK may be related to the pro-apoptotic factor P38 [76]. Expression of the transforming acidic coiled-coil protein-3 in RC patients was found to negatively correlate with sensitivity to nCRT (RR = 2.23, 95% CI: 1.44-3.45; p = 0.001), resulting in less pCR (p = 0.001) [77]. Yan et al [45] reported that low expression of RAD18 (an E3 ubiquitin-linked enzyme) in pre-nCRT biopsies of RC patients correlated to better clinical outcomes after treatment.…”
Section: Cellular Protein Biomarkersmentioning
confidence: 99%