Pretreatment plasma fibrinogen as an independent prognostic indicator of prostate cancer patients treated with androgen deprivation therapy

Wang, Y; Yin, Wen; Wang, Z; Huang, Jiwei; Pan, Jiahua; Zhu, Yao; Xu, Fan; Shao, Xiaoliang; Sha, Jianjun; Cai, Yong; Liu, Q; Dong, Baijun; Xue, Wei; Huang, Yiran

doi:10.1038/pcan.2016.6

Cited by 22 publications

(16 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to CRP, the plasma fibrinogen is also an acute-phase reaction protein of host response to tumor 10 , but its measurement is routinely performed. Besides, we have showed an association beween elevated plasma fibrinogen with poor clinical outcome for PCa patients 14 .…”

Section: Introductionmentioning

confidence: 67%

“…Ziaran et al 25 demonstrated a significant increase of fibrinogen levels in prostate cancer patients after 12 months of androgen deprivation therapy, indicating fibrinogen may be association with tolerance of ADT. Our previous study showed an association between elevated plasma fibrinogen with poor clinical outcome for PCa patients 14 . Besides, as an acute-phase reaction protein 10 , fibrinogen level would be increased during systemic response of host to tumor.…”

Section: Discussionmentioning

confidence: 92%

“…As part of systemic inflammatory response to the tumor or from the tumor itself, inflammatory mediators including interleukin-1 (IL-1), IL-6, necrosis factor ɑ and acute phase reactants were released, which might increase the transcapillary escape rate of albumin and modulate albumin synthesis by hepatocytes 19 - 22 , thus albumin level could serve as a good indicator of prognosis for cancer. As for fibrinogen level, numerous studies have released its role in the development of cancer, metastatic spread and prognostic assessment 14 , 23 - 25 . Yano HJ et al 23 showed that fibrinogen interacted with multiple integrin and non-integrin receptors of cancer cells to regulate tumor cell proliferation, migration, and signaling.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Albumin and Fibrinogen Combined Prognostic Grade Predicts Prognosis of Patients with Prostate Cancer

Wang¹,

Chen²,

Hu³

et al. 2017

J. Cancer

View full text Add to dashboard Cite

Background: The nutritional status and systemic inflammation are thought to be associated with outcome in multiple types of cancer. The objective of this study was to determine the prognostic value of pretreatment albumin and fibrinogen combined prognostic grade (AFPG) in prostate cancer (PCa).Methods: 462 prostate cancer patients who had undergone androgen deprivation therapy (ADT) as first-line therapy at four cencters were retrospectively analyzed. The serum albumin levels and plasma fibrinogen levels were measured at the time of diagnosis. The AFPG was calculated according to albumin and fibrinogen levels dichotomized by optimal cut-off values or clinical reference values. Univariate and multivariate cox regression analyses were performed to determine the associations of AFPG with progression-free survival (PFS), cancer-specific survival (CSS) and overall survival (OS). Prognostic accuracy was evaluated with the Harrell concordance index.Results: Multivariate analyses identified AFPG as an independent prognostic indicator for PFS, CSS and OS (each p < 0.01). According to optimal cut-off values, the addition of AFPG to the final models improved predictive accuracy for PFS, CSS and OS compared with the clinicopathological base models, which included Gleason score and incidence of metastasis. Moreover, AFPG according to optimal cut-off values was a better prognostic predictor than albumin levels alone or fibrinogen levels alone or AFPG according to clinical reference values.Conclusion: Decreased AFPG could predict a significantly poor prognosis in patients with PCa. Thus, we recommend adding AFPG according to optimal cut-off values to traditional prognostic model to improve the predictive accuracy.

show abstract

Section: Introductionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Albumin and Fibrinogen Combined Prognostic Grade Predicts Prognosis of Patients with Prostate Cancer

Wang¹,

Chen²,

Hu³

et al. 2017

J. Cancer

View full text Add to dashboard Cite

show abstract

“…Clinically, Fbg is a sensitive factor of the reaction of brinolytic system and hypercoagulable state. Not only that, brinogen is also considered to be an adhesion factor involved in tumor cell proliferation, angiogenesis and metastasis [34,35]. A large number of studies have shown that high levels of fasting igg in the body suggest a poor prognosis in patients with various cancers including nasopharyngeal cancer, esophageal cancer, colorectal cancer, and prostate cancer [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

The significance of blood cell biomarkers in the prognosis of gastric cancer

Zhang

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Studies have shown that inflammation-associated blood cell markers are associated with prognoses in a variety of tumors. However, the prognostic significance of these markers for gastric cancer (GC) is still not very clear. This article aims to explore its value of GC prognostic assessment.Methods From July 2011 to July 2016, 353 GC patients with surgical treatment were enrolled in this retrospective study. Patients’ demographics were analyzed along with clinical and pathologic data. The chi-square test was used to evaluate relationships between the markers and other clinicopathological variables; The Kaplan–Meier method and Cox regression proportional hazard model were performed to evaluate prognostic factors.Results Univariate analysis indicated T stage, N stage, vascular tumor thrombus, tumor long diameter, Bormann Classification, preoperative MWR (monocyte/leukocyte ratio), preoperative serum CEA levels are prognostic factors for GC. Multivariate analysis showed that preoperative MWR, tumor differentiation, and tumor length were independent prognostic factors in patients with GC. The boundary value of MWR is 0.8.Conclusion Preoperative MWR was convenient, simple marker of gastric cancer, might be useful for the evaluation of prognosis of patients with GC. Comparing with TNM stage, tumor differentiation was a more reliable pathological factor evaluating recurrence.

show abstract

“…4. Pretreatment plasma fibrinogen as an independent prognostic indicator of prostate cancer patients treated with androgen deprivation therapy [4]. Authors found that pretreatment plasma fibrinogen was an independent prognostic indicator for Chinese prostate cancer patients who received ADT.…”

mentioning

confidence: 98%

Prostate cancer and prostatic diseases Best of China, 2018

Zhu

2018

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

Pretreatment plasma fibrinogen as an independent prognostic indicator of prostate cancer patients treated with androgen deprivation therapy

Cited by 22 publications

References 21 publications

Albumin and Fibrinogen Combined Prognostic Grade Predicts Prognosis of Patients with Prostate Cancer

Albumin and Fibrinogen Combined Prognostic Grade Predicts Prognosis of Patients with Prostate Cancer

The significance of blood cell biomarkers in the prognosis of gastric cancer

Prostate cancer and prostatic diseases Best of China, 2018

Contact Info

Product

Resources

About