Pretransplant Immune- and Apoptosis-Related Gene Expression Is Associated with Kidney Allograft Function

Kamińska, Dorota; Kościelska‐Kasprzak, Katarzyna; Chudoba, P.; Mazanowska, Oktawia; Banasik, Mirosław; Żabińska, Marcelina; Boratyńska, Maria; Lepiesza, Agnieszka; Gomółkiewicz, Agnieszka; Dzięgiel, Piotr; Klinger, Marian

doi:10.1155/2016/8970291

Cited by 4 publications

(3 citation statements)

References 41 publications

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“…Studies have suggested that IL-18 with NGAL and creatinine are the most sensitive markers of DGF [ 40 ]. Moreover, IL-18 positively correlates with kidney function at 6 and 24 months after transplantation [ 41 ]. Urine-detected IL-18 is an early diagnostic marker of acute kidney injury (AKI), and it precedes symptoms by 24–48 h [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Endothelins, IL-18, and NGAL in Kidney Hypothermic Machine Perfusion

et al. 2021

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Ischemia-reperfusion injury (IRI) occurring after renal transplantation is a complex biochemical process that can be monitored by specific biomarkers. The roles of those are not yet fully elucidated. The aim of this study was to analyze the concentrations of endothelins (ET-1, ET-2, and ET-3), interleukin-18 (IL-18), and neutrophil gelatinase-associated lipocalin (NGAL) during the reperfusion of human kidneys grafted from brain dead donors and later transplanted. The study group (n = 44) was analyzed according to the method of kidney storage: Group 1 underwent hypothermic machine perfusion (HMP) in the LifePort perfusion pump (n = 22), and Group 2 underwent static cold storage (SCS) (n = 22). The analysis of kidney function was performed daily during the first seven days after transplantation. The kidneys in Group 1 were characterized by higher absolute concentrations of ET-1, IL-18, and NGAL, as well as a lower concentration of ET-2 (p = 0.017) and ET-3. The relative increase of ET-1 (p = 0.033), ET-2, and ET-3 during reperfusion was lower in this group, while the relative decrease of NGAL was higher. Group 1 was also characterized by significant decrease of IL-18 (p = 0.026) and a tendency for better kidney function based on the higher total diuresis, higher glomerular filtration rate (GFR), higher potassium level, lower serum creatinine, and lower urea concentration during the seven-day postoperative observation period. The long-term beneficial impact of hypothermic machine perfusion on the outcome of transplanted kidneys may rely on the early modified proceedings and intensity of ischemia-reperfusion injury reflected by the dynamics of the concentrations of examined biomarkers.

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Section: Discussionmentioning

confidence: 99%

The Role of Endothelins, IL-18, and NGAL in Kidney Hypothermic Machine Perfusion

et al. 2021

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“…Pretransplant peripheral blood TGF-β gene expression was found to negatively influence immediate post-transplant kidney allograft function [ 128 ]. Compared with normal kidney tissue, a high gene expression of TGF-β1 was identified in kidneys retrieved from brain dead donors.…”

Section: Biomarkers Of Kidney Injury Progressionmentioning

confidence: 99%

Biomarkers in Primary Focal Segmental Glomerulosclerosis in Optimal Diagnostic-Therapeutic Strategy

Musiała

Donizy

Augustyniak−Bartosik

et al. 2022

JCM

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Focal segmental glomerulosclerosis (FSGS) involves podocyte injury. In patients with nephrotic syndrome, progression to end-stage renal disease often occurs over the course of 5 to 10 years. The diagnosis is based on a renal biopsy. It is presumed that primary FSGS is caused by an unknown plasma factor that might be responsible for the recurrence of FSGS after kidney transplantation. The nature of circulating permeability factors is not explained and particular biological molecules responsible for inducing FSGS are still unknown. Several substances have been proposed as potential circulating factors such as soluble urokinase-type plasminogen activator receptor (suPAR) and cardiolipin-like-cytokine 1 (CLC-1). Many studies have also attempted to establish which molecules are related to podocyte injury in the pathogenesis of FSGS such as plasminogen activator inhibitor type-1 (PAI-1), angiotensin II type 1 receptors (AT1R), dystroglycan(DG), microRNAs, metalloproteinases (MMPs), forkheadbox P3 (FOXP3), and poly-ADP-ribose polymerase-1 (PARP1). Some biomarkers have also been studied in the context of kidney tissue damage progression: transforming growth factor-beta (TGF-β), human neutrophil gelatinase-associated lipocalin (NGAL), malondialdehyde (MDA), and others. This paper describes molecules that could potentially be considered as circulating factors causing primary FSGS.

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“…These studies have been more commonly performed on renal biopsy samples as they provide sufficient material for RNA extraction. As listed in Table 1, gene signatures associated with fibrosis, i-IFTA, chronic rejection (ABMR and TCMR) and graft failure can be identified by determining gene expression profiling (45)(46)(47)(48)(49)(50)(51)(52)(53). Importantly, the gene set has higher predictive capacity than that of baseline clinical variables, and clinical and pathological variables.…”

Section: Transcriptomic Biomarkersmentioning

confidence: 99%

Tackling Chronic Kidney Transplant Rejection: Challenges and Promises

et al. 2021

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Despite advances in post-transplant management, the long-term survival rate of kidney grafts and patients has not improved as approximately forty percent of transplants fails within ten years after transplantation. Both immunologic and non-immunologic factors contribute to late allograft loss. Chronic kidney transplant rejection (CKTR) is often clinically silent yet progressive allogeneic immune process that leads to cumulative graft injury, deterioration of graft function. Chronic active T cell mediated rejection (TCMR) and chronic active antibody-mediated rejection (ABMR) are classified as two principal subtypes of CKTR. While significant improvements have been made towards a better understanding of cellular and molecular mechanisms and diagnostic classifications of CKTR, lack of early detection, differential diagnosis and effective therapies continue to pose major challenges for long-term management. Recent development of high throughput cellular and molecular biotechnologies has allowed rapid development of new biomarkers associated with chronic renal injury, which not only provide insight into pathogenesis of chronic rejection but also allow for early detection. In parallel, several novel therapeutic strategies have emerged which may hold great promise for improvement of long-term graft and patient survival. With a brief overview of current understanding of pathogenesis, standard diagnosis and challenges in the context of CKTR, this mini-review aims to provide updates and insights into the latest development of promising novel biomarkers for diagnosis and novel therapeutic interventions to prevent and treat CKTR.

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Pretransplant Immune- and Apoptosis-Related Gene Expression Is Associated with Kidney Allograft Function

Cited by 4 publications

References 41 publications

The Role of Endothelins, IL-18, and NGAL in Kidney Hypothermic Machine Perfusion

The Role of Endothelins, IL-18, and NGAL in Kidney Hypothermic Machine Perfusion

Biomarkers in Primary Focal Segmental Glomerulosclerosis in Optimal Diagnostic-Therapeutic Strategy

Tackling Chronic Kidney Transplant Rejection: Challenges and Promises

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