Preterm Delivery and Low Birth Weight Among Neonates Conceived With Intracytoplasmic Sperm Injection Compared With Conventional In Vitro Fertilization

Keyhan, S.; Truong, Tracy; Li, Yi-Ju; Jackson-Bey, Tia; Eaton, Jennifer L.

doi:10.1097/aog.0000000000002423

Cited by 6 publications

(7 citation statements)

References 12 publications

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“…At the same time, we noticed that the rate of multiple pregnancies in the frozen sperm group was 5% higher than that of the fresh group. As LBW is a known complication of multiple pregnancies (21,22), and our study also showed that LBW is significantly related to single or Newborns in two groups twin pregnancies, we investigated the incidence of LBW in twin and single pregnancy separately. Our final results demonstrated that the rates of LBW in twin pregnancy and single pregnancy between the two groups were similar.…”

Section: Discussionmentioning

confidence: 91%

Comparison of pregnancy and neonatal outcomes of intracytoplasmic sperm injection performed with frozen versus fresh testicular sperm

Wu¹,

Zhao²,

Wu³

et al. 2022

Transl Androl Urol

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Background: It remains controversial whether there is a difference in the prognosis of intracytoplasmic sperm injection (ICSI) using frozen or fresh testicular sperm in patients with obstructive azoospermia (OA). Moreover, in the available studies, few have tracked neonatal outcomes. This study aimed to compare the pregnancy and neonatal outcomes of ICSI using cryopreserved sperm versus fresh sperm collected by testicular sperm aspiration (TESA).Methods: A total of 317 OA patients treated with ICSI in a university affiliated hospital from January 2016 to December 2020 were included in this study. The participants were divided into two groups according to the type of sperm used for ICSI: frozen sperm group (n=154) and fresh sperm group (n=163). The pregnancy and neonatal outcomes of the two groups were compared. Results:The data produced by this study showed no significant statistical difference in the 2 pronuclei (2PN) fertilization rate, 2PN cleavage rate, high-quality blastocyst rate, and the average number of transferred embryos in the frozen and fresh sperm groups. Similarly, no difference was found in implantation rate, clinical pregnancy rate, multiple pregnancy rate, miscarriage rate, premature delivery rate, live birth rate, and gender ratio at birth (P>0.05). The average newborn birth weight was similar in both groups (2,932.61±728.40 vs. 3,100.32±515.64 g, respectively) (P>0.05). A higher incidence of low birthweight (LBW) newborns was found in the frozen sperm group (20.91% vs. 8.49%) (P<0.05). Multiple logistic regression analysis showed that LBW is related to single or twin pregnancies (P<0.01), but not sperm (frozen or fresh) (P>0.05). We further analyzed the twin and single pregnancies in the two groups separately, and found that the incidences of LBW were both similar (P>0.05). There was no difference in the Apgar scores at 1 min and 5 min after birth between the two groups (P>0.05). Conclusions:The use of frozen testicular sperm by TESA was efficient for men with OA. There were similar pregnancy and neonatal outcomes following TESA-ICSI using frozen or fresh sperm in this retrospective study. Prospective investigations are needed for further validation.

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Section: Discussionmentioning

confidence: 91%

Comparison of pregnancy and neonatal outcomes of intracytoplasmic sperm injection performed with frozen versus fresh testicular sperm

Wu¹,

Zhao²,

Wu³

et al. 2022

Transl Androl Urol

View full text Add to dashboard Cite

show abstract

“…showed that there was a lower risk of PTD in ICSI singletons than in IVF singletons, indicating that the fertilization procedure might have an effect on this perinatal outcome ( 12 ). Nevertheless, other work described that the reason behind this difference was that the high risk of PTD in IVF singletons might be secondary to female inherent risk factors instead of IVF itself ( 9 ). Although the type of IVF/ICSI treatment might not affect PTD, we found women with GnRH-antagonist protocol had higher risk to deliver a preterm baby, while women with GnRH-agonist protocol had lower risk.…”

Section: Discussionmentioning

confidence: 99%

“…However, data available by Keyhan et al. did not support this finding ( 9 ). No increasing risk of PTD was observed by Keyhan et al.…”

Section: Introductionmentioning

confidence: 96%

“…As mentioned, it is a key cause of newborn deaths, which can bring up new couples’ significant socioeconomic burden ( 5 , 6 , 8 ). There is still no consensus on which factors are associated with the increasing risk of PTD in IVF/ICSI cycles ( 9 ). In an analysis of 144018 IVF cycles, many patients’ inherent risk factors, such as infertility duration, cause of infertility, and donor oocytes, were responsible for a higher incidence of PTD ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

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Nomogram for predicting the risk of preterm delivery after IVF/ICSI treatment: an analysis of 11513 singleton births

Liao

Liu

et al. 2023

Front. Endocrinol.

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BackgroundThere is a higher risk of preterm delivery (PTD) in singleton live births conceived after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) compared with spontaneously conceived pregnancies. The objective of our study was to build a predictive nomogram model to suggest the possibility of PTD in singleton pregnancies after IVF/ICSI treatment.Method11513 IVF/ICSI cycles with singleton live births were enrolled retrospectively. These cycles were randomly allocated into a training group (80%) and a validation group (20%). We used the multivariate logistics regression analysis to determine prognostic factors for PTD in the training group. A nomogram based on the above factors was further established for predicting PTD. Receiver operating characteristic curves (ROC), areas under the ROC curves (AUC), concordance index (C-index), and calibration plots were analyzed for assessing the performance of this nomogram in the training and validation group.ResultsThere were fourteen risk factors significantly related to PTD in IVF/ICSI singleton live births, including maternal body mass index (BMI) > 24 kg/m2, smoking, uterine factors, cervical factors, ovulatory factors, double embryo transferred (DET), blastocyst transfer, FET, vanishing twin syndrome (VTS), obstetric complications (placenta previa, placenta abruption, hypertensive of pregnancies, and premature rupture of membrane), and a male fetus. These factors were further incorporated to construct a nomogram prediction model. The AUC, C-index, and calibration curves indicated that this nomogram exhibited fair performance and good calibration.ConclusionsWe found that the occurrence of PTD increased when women with obesity, smoking, uterine factors, cervical factors, ovulatory factors, DET, VTS, and obstetric complications, and a male fetus. Furthermore, a nomogram was constructed based on the above factors and it might have great value for clinic use.

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“…The above situation is more prominent in multiple pregnancies. LBW is a known complication of multiple gestation [20]. A recently published research revealed that mothers with multiple pregnancies were at a signi cantly increased risk of delivering babies with LBW, both in the case of preterm and term birth [21].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Pregnancy and Neonatal Outcomes of ICSI Performed With Frozen Versus Fresh TESA Sperm in Patients With Obstructive Azoospermia: a Retrospective Study

Xia

et al. 2021

Preprint

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BackgroundIt is commonly believed that using frozen sperms after TESA was effective for OA patients. Nevertheless, scholars are worried about the prognosis of ICSI with frozen testicular sperm. In this study, we aim to compare the pregnancy and neonatal outcomes of ICSI using cryopreserved versus fresh spermatozoa collected by TESA.MethodsA total of 317 cases of OA patients treated with ICSI in a university affiliated hospital from January 2016 to December 2020 were included in this retrospective study, and they were divided into two groups according to the sperm used for ICSI: Frozen sperm group (N=154) and Fresh sperm group(N=163). The outcomes were measured by the following indicators: Two pronucleus (2PN) fertilization rate, 2PN cleavage rate, high-quality blastocyst rate, average number of embryos transferred, implantation rate, clinical pregnancy rate, multiple pregnancy rate, miscarriage rate, preterm birth rate, live birth rate (LBR) , sex ratio at birth (male) and average newborn birth weight.ResultsThe present data showed no statistically significant difference in 2PN fertilization rates, 2PN cleavage rates, high-quality blastocyst rates and the average number of embryos transferred in the two groups. Similarly, no difference was found in implantation rate, clinical pregnancy rate, multiple pregnancy rate, miscarriage rate, premature delivery rate, LBR and sex ratio at birth (P>0.05). The average newborn birth weight was similar in the two groups (2932.61±728.40 vs 3100.32±515.64) (P>0.05), but there was a higher incidence of Low-Birth-Weight newborn in the frozen group (20.91% vs 8.49%)(P<0.05). ConclusionsAs for men with obstructive azoospermia, the use of frozen testicular sperm by TESA was efficient. There was a similar pregnancy outcome of ICSI using frozen or fresh spermatozoa collected by TESA. However, it may lead to higher incidence of newborns of low birth weight, which needs further research based on larger samples.

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Preterm Delivery and Low Birth Weight Among Neonates Conceived With Intracytoplasmic Sperm Injection Compared With Conventional In Vitro Fertilization

Cited by 6 publications

References 12 publications

Comparison of pregnancy and neonatal outcomes of intracytoplasmic sperm injection performed with frozen versus fresh testicular sperm

Comparison of pregnancy and neonatal outcomes of intracytoplasmic sperm injection performed with frozen versus fresh testicular sperm

Nomogram for predicting the risk of preterm delivery after IVF/ICSI treatment: an analysis of 11513 singleton births

Comparison of the Pregnancy and Neonatal Outcomes of ICSI Performed With Frozen Versus Fresh TESA Sperm in Patients With Obstructive Azoospermia: a Retrospective Study

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