Preterm birth alters neonatal, functional rich club organization

Mayes, Linda C.; Kwon, Soo Hyun; Shen, Xilin; Lacadie, Cheryl; Schneider, Karen; Dai, Feng; Ment, Laura R.; Constable, R. Todd

doi:10.1007/s00429-015-1096-6

Cited by 78 publications

(51 citation statements)

References 44 publications

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“…Our findings suggest that even in the absence of structural brain injury, the developmental trajectory of the preterm brain is altered over the third trimester. Evidence of clinical 4 .01 * 14.17 ± 1.6 [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] 13.91 ± 2.7 [8][9][10][11][12][13][14][15][16][17][18][19][20] .66…”

Section: Discussionmentioning

confidence: 99%

“…11,12 To date, most inferences about thirdtrimester brain development in preterm infants have been based on comparative quantitative MRI measures versus those of term healthy newborns at a single time point at the end of the third trimester (ie, TEA). However, these crosssectional studies at the end of the third trimester were not designed to identify the onset and evolution of impaired brain development in the premature infant.…”

Section: What This Study Addsmentioning

confidence: 99%

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Third Trimester Brain Growth in Preterm Infants Compared With In Utero Healthy Fetuses

et al. 2016

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BACKGROUND AND OBJECTIVES:Compared with term infants, preterm infants have impaired brain development at term-equivalent age, even in the absence of structural brain injury. However, details regarding the onset and progression of impaired preterm brain development over the third trimester are unknown. Our primary objective was to compare third-trimester brain volumes and brain growth trajectories in ex utero preterm infants without structural brain injury and in healthy in utero fetuses. As a secondary objective, we examined risk factors associated with brain volumes in preterm infants over the thirdtrimester postconception.

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Section: Discussionmentioning

confidence: 99%

Section: What This Study Addsmentioning

confidence: 99%

Third Trimester Brain Growth in Preterm Infants Compared With In Utero Healthy Fetuses

et al. 2016

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“…Concomitantly, long-distance links are preferentially strengthened during the first year of life, leveling off thereafter (Gao et al, 2011). Rich clubs are also evident in both structural and functional networks in neonates along with both high functional modularity and integration capacity between modules (Ball et al, 2014; Scheinost et al, 2016a; van den Heuvel et al, 2015b). These findings suggest that the development of a small-world architecture, as well as the capacity for globally efficient communication and integration, largely occurs during the first year of life and prenatally, a finding that is supported by multimodal structural and functional network analysis in preterm infants (Ball et al, 2014; van den Heuvel et al, 2015b).…”

Section: Functional Brain Organization In Infants and Toddlersmentioning

confidence: 99%

Development of large-scale functional networks from birth to adulthood: A guide to the neuroimaging literature

2017

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The development of human cognition results from the emergence of coordinated brain activity betweeen distant brain areas. Network science, combined with non-invasive functional imaging, has generated unprecedented insights regarding the adult brain’s functional organization, and promises to help elucidate the development of functional architectures supporting complex behavior. Here we review what is known about functional network development from birth until adulthood, particularly as understood through the use of resting-state functional connectivity MRI (rs-fcMRI). We attempt to synthesize rs-fcMRI findings with other functional imaging techniques, with macro-scale structural connectivity, and with knowledge regarding the development of micro-scale structure. We highlight a number of outstanding conceptual and technical barriers that need to be addressed, as well as previous developmental findings that may need to be revisited. Finally, we discuss key areas ripe for future research in order to 1) better characterize normative developmental trajectories, 2) link these trajectories to biologic mechanistic events, as well as component behaviors and 3) better understand the clinical implications and pathophysiological basis of aberrant network development.

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“…However, alterations in the global framework of brain wiring have not been observed and are unlikely in the absence of major brain lesions (Bütefisch, 2004). The adverse effects of preterm birth have predominantly been noted to affect the quality of connections rather than their overall layout (Ball et al, , 2013Doria et al, 2010a;Scheinost et al, 2015;Smyser et al, 2010;Toulmin et al, 2015).…”

Section: Postnatal Brain Developmentmentioning

confidence: 99%

The emergence of functional architecture during early brain development

2017

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Early human brain development constitutes a sequence of intricate processes resulting in the ontogeny of functionally operative neural circuits. Developmental trajectories of early brain network formation are genetically programmed and can be modified by epigenetic and environmental influences. Such alterations may exert profound effects on neurodevelopment, potentially persisting throughout the lifespan. This review focuses on the critical period of fetal and early postnatal brain development. Here we collate findings from neuroimaging studies, with a particular focus on functional MRI research that interrogated early brain network development in both health and high-risk or disease states. First, we will provide an overview of the developmental processes that take place from the embryonic period through early infancy in order to contextualize brain network formation. Second, functional brain network development in the typically developing brain will be discussed. Third, we will touch on prenatal and perinatal risk factors that may interfere with the trajectories of functional brain wiring, including prenatal substance exposure, maternal mental illness and preterm

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Preterm birth alters neonatal, functional rich club organization

Cited by 78 publications

References 44 publications

Third Trimester Brain Growth in Preterm Infants Compared With In Utero Healthy Fetuses

Third Trimester Brain Growth in Preterm Infants Compared With In Utero Healthy Fetuses

Development of large-scale functional networks from birth to adulthood: A guide to the neuroimaging literature

The emergence of functional architecture during early brain development

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