Presynaptic Rac1 in the hippocampus selectively regulates working memory
Jaebin Kim,
Edwin Bustamante,
Peter Sotonyi
et al.
Abstract:One of the most extensively studied members of the Ras superfamily of small GTPases, Rac1 is an intracellular signal transducer that remodels actin and phosphorylation signaling networks. Previous studies have shown that Rac1-mediated signaling is associated with hippocampal-dependent working memory and longer-term forms of learning and memory and that Rac1 can modulate forms of both pre- and postsynaptic plasticity. How these different cognitive functions and forms of plasticity mediated by Rac1 are linked, h… Show more
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