Presymptomatic differences in Toll-like receptor function in infants who have allergy

Prescott, Susan L.; Noakes, Paul S.; Chow, Bonita W.Y.; Breckler, L.A.; Thornton, Catherine A.; Hollams, Elysia M.; Ali, May; Biggelaar, Anita H. J. van den; Tulic, Meri K.

doi:10.1016/j.jaci.2008.04.042

Cited by 93 publications

(94 citation statements)

References 28 publications

(27 reference statements)

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“…It is important to stress that no data were found in medical literature concerning the estimation of this receptor in children with food allergy. However, Prescott et al [34] and Vanhisbergh et al [16] showed a lower expression of this receptor in children with allergy in general. The research of Remer et al [35], important in food allergy, showed that TLR4 is directly included in respiratory burst.…”

Section: Discussionmentioning

confidence: 96%

Evaluation of TLR4 expression and chosen parameters of oxidative-antioxidative balance in young children with food allergy.

Kamer

Kulig²,

Lewkowicz³

et al. 2010

Folia Histochem Cytobiol.

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Abstract:The authors evaluated mRNA TLR4 expression on neutrophils and the chosen parameters of oxidative-antioxidative balance in blood of 35 children with food allergy (17 of them with IgE-dependent allergy and 18 with IgE-independent allergy) and 15 healthy children without any allergy. The age of these children ranged from 1 to 36 months. Children with food allergy in comparison with healthy children were found to have lower mRNA TLR4 expression, higher average value of chemiluminescence (CL) and its increase after stimulation by fMLP, PMA and OZ as well as lower TAS values. Disturbances of oxidative-antioxidative balance were found in children with food allergy. We suggest that natural immunity is involved in the development of food allergy mechanisms. Moreover, chemiluminescence can be used as an additional diagnostic test.

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Section: Discussionmentioning

confidence: 96%

Evaluation of TLR4 expression and chosen parameters of oxidative-antioxidative balance in young children with food allergy.

Kamer

Kulig²,

Lewkowicz³

et al. 2010

Folia Histochem Cytobiol.

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“…This could also be due to the fact that there were few allergic children included in these analyses, although we did detect higher levels of TLR2 mRNA expression in non-allergic than allergic infants at 12 months of age. Other studies suggest differences in TLR responsiveness between children who do or do not develop allergy [85][86][87].…”

Section: Lactobacillus Reuteri and Toll-like Receptorsmentioning

confidence: 99%

Lactobacillus reuteri, Infant Allergy Prevention and Childhood Immune Maturation

Forsberg¹

2016

Probiotics and Prebiotics in Human Nutrition and Health

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The increasing allergy prevalence in affluent countries may be caused by reduced microbial stimulation, resulting in an abnormal postnatal immune maturation. This chapter concerns the theories behind the use of probiotics in randomized prevention trials, and how this supplementation affects the immunity of pregnant women, the immune development in their children, and possibly preventing allergic diseases. Most studies investigating the underlying mechanisms have focused on postnatal microbial exposure. An increasing body of evidence from studies suggests that the maternal microbial environment during pregnancy can program the immune development of the child. In human allergy intervention studies, probiotic supplementation to the mother during pregnancy, as well as to her baby postnatally, may be important for preventive effects. Also, prenatal environmental exposures may alter gene expression via epigenetic mechanisms, aiming to induce physiological adaptations to the anticipated postnatal environment. The maternal microbial environment during pregnancy may program the immune development of the child.

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“…В одном из исследований выявлена повышенная продукция фактора некроза опу-холи (ФНО) ␣ и ИЛ 1 в мононуклеарных клетках пуповин-ной крови при активации TLR-2, -4 и -5 у новорожден-ных, у которых позже диагностировали аллергические заболевания. Это свидетельствует о взаимосвязи между повышенным у новорожденных TLR-ответом и развитием аллергии [47].…”

Section: кишечная микрофлора и оральная толерантностьunclassified

Intestinal Microbiocenosis, Food Tolerance and Food Allergy. Current State of a Problem

Макарова¹,

Boldyreva²,

Лаврова³

et al. 2014

Vopr. sovr. pediatr.

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In the review of modern literature the influence of a bacterial factor, first of all -indigenous microflora -on formation of food tolerance and immune answer of a child as a whole is in detail considered. Formation of a microbiocenosis, food and autogenic tolerance happens under the general laws. In this process the primary colonization of intestines and formation of a microflora variety which, as results of the last researches show, comes to an end by 2-4 years of life of a child has special value. In the review the major factors influencing the formation of a child intestinal microbiota both antenatal and postnatal and for the first years of life, and also their interaction are considered. The influence of a bacterial factor on formation of food tolerance and sensibilization processes, and also mechanisms of this influence is in detail discussed. The data on features of a structure of intestinal microflora at children with food allergy including the results of own researches devoted to microbiocenosis at children with food allergy and to development of tactics of managementВ развитии аллергических форм патологии боль-шую роль играет наследственная предрасположенность. Вместе с тем генетические факторы не могут объяснить повышения частоты аллергических реакций на ком-поненты пищи, которые в последние годы образно называют «второй волной» эпидемии аллергии: на фоне некоторого снижения темпов роста распространенно-сти респираторной аллергии отмечается резкое увели-чение частоты патологических состояний, связанных с нарушением процессов формирования толерантности к пище [1]. Принято считать, что «первая волна аллер-гии» в 70-80-е гг. XX в. была связана с современным (западным) образом жизни, воздействием изменения рациона питания, ксенобиотиков пищи, а также загряз-нением окружающей среды и др. Остается неясным, почему «волна пищевой аллергии» отстала от «первой

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Presymptomatic differences in Toll-like receptor function in infants who have allergy

Cited by 93 publications

References 28 publications

Evaluation of TLR4 expression and chosen parameters of oxidative-antioxidative balance in young children with food allergy.

Evaluation of TLR4 expression and chosen parameters of oxidative-antioxidative balance in young children with food allergy.

Lactobacillus reuteri, Infant Allergy Prevention and Childhood Immune Maturation

Intestinal Microbiocenosis, Food Tolerance and Food Allergy. Current State of a Problem

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