Presumed Choroidal Langerhans Cell Histiocytosis Following a Previously Resected Solitary Central Nervous System Lesion in an Adult

Langerhans Cell Histiocytosis of the Uvea with a Ciliochoroidal Mass: A Case Report of Management with Systemic Therapy

“…Considering his unremarkable laboratory work-up and systemic disease, we concluded that MS-LCH was the cause of his ophthalmic symptoms. Similar cases of choroidal LCH presenting as unilateral choroidal masses, panuveitis, or a combination of both have been reported (Table 1) [7,10,[12][13][14]. In one case, a diagnosis of choroidal melanoma was made, but immunohistochemical studies revealed LCH [10], and in the second eye, the iris portion of an iridociliochoroidal mass was found to be LCH after fine-needle aspiration [7].…”

“…Considering the rare incidence of intraocular involvement of LCH, there is no standard treatment. Patton et al [13] reported the first case of choroidal involvement as a mass by LCH and documented successful outcomes of fractionated low-dose, whole-eye external beam radiotherapy for choroidal LCH. Shields et al [7] used brachytherapy for treatment of an iridociliochoroidal tumor in a 6-year-old boy with known MS-LCH.…”

Langerhans Cell Histiocytosis of the Uvea with a Ciliochoroidal Mass: A Case Report of Management with Systemic Therapy

“…Considering his unremarkable laboratory work-up and systemic disease, we concluded that MS-LCH was the cause of his ophthalmic symptoms. Similar cases of choroidal LCH presenting as unilateral choroidal masses, panuveitis, or a combination of both have been reported (Table 1) [7,10,[12][13][14]. In one case, a diagnosis of choroidal melanoma was made, but immunohistochemical studies revealed LCH [10], and in the second eye, the iris portion of an iridociliochoroidal mass was found to be LCH after fine-needle aspiration [7].…”

“…Considering the rare incidence of intraocular involvement of LCH, there is no standard treatment. Patton et al [13] reported the first case of choroidal involvement as a mass by LCH and documented successful outcomes of fractionated low-dose, whole-eye external beam radiotherapy for choroidal LCH. Shields et al [7] used brachytherapy for treatment of an iridociliochoroidal tumor in a 6-year-old boy with known MS-LCH.…”

Langerhans cell histiocytosis of the uvea with a ciliochoroidal mass: a Case report of management with systemic therapy

“…Considering his unremarkable laboratory work-up and systemic disease, we concluded that MS-LCH was the cause of his ophthalmic symptoms. Similar cases of choroidal LCH presenting as unilateral choroidal masses, or panuveitis, or a combination of both have been reported (Table1) [7,10,12,13,14]. In one case, a diagnosis of choroidal melanoma was made, but immunohistochemical studies revealed LCH [10], and in the second eye, the iris portion of an iridociliochoroidal mass was found to be LCH after ne-needle aspiration (7).…”

Atypical Choroidal Mass in an Adult

“…7,8 One developed after a previously excised solitary cerebral parenchymal lesion and was treated with external beam radiotherapy with response. 7 The other one had a unifocal choroidal lesion with no systemic involvement and underwent enucleation for suspicion of a choroidal melanoma. 8 Review of their clinical manifestations demonstrated some common features such as an amelanotic, mildly elevated choroidal lesion in the posterior area, with echodensity on ultrasonography and hypofluorescence on ICG angiography.…”

“…In our review of the literature, we identified 2 case reports of solitary choroidal LCH in adults . One developed after a previously excised solitary cerebral parenchymal lesion and was treated with external beam radiotherapy with response .…”

Langerhans Cell Histiocytosis of the Uvea with a Ciliochoroidal Mass: A Case Report of Management with Systemic Therapy

“…Considering his unremarkable laboratory work-up and systemic disease, we concluded that MS-LCH was the cause of his ophthalmic symptoms. Similar cases of choroidal LCH presenting as unilateral choroidal masses, panuveitis, or a combination of both have been reported (Table 1) [7,10,[12][13][14]. In one case, a diagnosis of choroidal melanoma was made, but immunohistochemical studies revealed LCH [10], and in the second eye, the iris portion of an iridociliochoroidal mass was found to be LCH after fine-needle aspiration [7].…”

“…Considering the rare incidence of intraocular involvement of LCH, there is no standard treatment. Patton et al [13] reported the first case of choroidal involvement as a mass by LCH and documented successful outcomes of fractionated low-dose, whole-eye external beam radiotherapy for choroidal LCH. Shields et al [7] used brachytherapy for treatment of an iridociliochoroidal tumor in a 6-year-old boy with known MS-LCH.…”

Langerhans cell histiocytosis of the uvea with a ciliochoroidal mass: a Case report of management with systemic therapy

“…Considering his unremarkable laboratory work-up and systemic disease, we concluded that MS-LCH was the cause of his ophthalmic symptoms. Similar cases of choroidal LCH presenting as unilateral choroidal masses, or panuveitis, or a combination of both have been reported (Table1) [7,10,12,13,14]. In one case, a diagnosis of choroidal melanoma was made, but immunohistochemical studies revealed LCH [10], and in the second eye, the iris portion of an iridociliochoroidal mass was found to be LCH after ne-needle aspiration (7).…”

Atypical Choroidal Mass in an Adult

“…7,8 One developed after a previously excised solitary cerebral parenchymal lesion and was treated with external beam radiotherapy with response. 7 The other one had a unifocal choroidal lesion with no systemic involvement and underwent enucleation for suspicion of a choroidal melanoma. 8 Review of their clinical manifestations demonstrated some common features such as an amelanotic, mildly elevated choroidal lesion in the posterior area, with echodensity on ultrasonography and hypofluorescence on ICG angiography.…”

“…In our review of the literature, we identified 2 case reports of solitary choroidal LCH in adults . One developed after a previously excised solitary cerebral parenchymal lesion and was treated with external beam radiotherapy with response .…”

Langerhans Cell Histiocytosis of the Uvea with a Ciliochoroidal Mass: A Case Report of Management with Systemic Therapy

“…Considering his unremarkable laboratory work-up and systemic disease, we concluded that MS-LCH was the cause of his ophthalmic symptoms. Similar cases of choroidal LCH presenting as unilateral choroidal masses, panuveitis, or a combination of both have been reported (Table 1) [7,10,[12][13][14]. In one case, a diagnosis of choroidal melanoma was made, but immunohistochemical studies revealed LCH [10], and in the second eye, the iris portion of an iridociliochoroidal mass was found to be LCH after fine-needle aspiration [7].…”

“…Considering the rare incidence of intraocular involvement of LCH, there is no standard treatment. Patton et al [13] reported the first case of choroidal involvement as a mass by LCH and documented successful outcomes of fractionated low-dose, whole-eye external beam radiotherapy for choroidal LCH. Shields et al [7] used brachytherapy for treatment of an iridociliochoroidal tumor in a 6-year-old boy with known MS-LCH.…”

Langerhans cell histiocytosis of the uvea with a ciliochoroidal mass: a Case report of management with systemic therapy

“…Considering his unremarkable laboratory work-up and systemic disease, we concluded that MS-LCH was the cause of his ophthalmic symptoms. Similar cases of choroidal LCH presenting as unilateral choroidal masses, or panuveitis, or a combination of both have been reported (Table1) [7,10,12,13,14]. In one case, a diagnosis of choroidal melanoma was made, but immunohistochemical studies revealed LCH [10], and in the second eye, the iris portion of an iridociliochoroidal mass was found to be LCH after ne-needle aspiration (7).…”

Atypical Choroidal Mass in an Adult

“…7,8 One developed after a previously excised solitary cerebral parenchymal lesion and was treated with external beam radiotherapy with response. 7 The other one had a unifocal choroidal lesion with no systemic involvement and underwent enucleation for suspicion of a choroidal melanoma. 8 Review of their clinical manifestations demonstrated some common features such as an amelanotic, mildly elevated choroidal lesion in the posterior area, with echodensity on ultrasonography and hypofluorescence on ICG angiography.…”

“…In our review of the literature, we identified 2 case reports of solitary choroidal LCH in adults . One developed after a previously excised solitary cerebral parenchymal lesion and was treated with external beam radiotherapy with response .…”