Pressure‐Accelerated Azide–Alkyne Cycloaddition: Micro Capillary versus Autoclave Reactor Performance

Abstract

Noël, T.; Wang, Q.; Busch, M.; Hessel, V.

Utilization of milli-scale coiled flow inverter in combination with phase separator for continuous flow liquid–liquid extraction processes

“…It has two fundamental pillars that are chemical intensification and process-design intensification. Chemical intensification makes use of highly intensified, unusual and typically harsh process conditions to boost microprocessing [8][9][10][11][12][13][14][15][16][17]. Process-design intensification is based on process simplification and integration [18][19][20].…”

High-Pressure Studies of 4-Acetamidobenzenesulfonyl Azide: Combined Raman Scattering, IR Absorption, and Synchrotron X-ray Diffraction Measurements

“…As a class of energetic materials, azides have been extensively studied for their vital importance in nitrogen sources, initial explosives, propellants, and combustibles. − In particular, recently, the application of pressure in the study of azides has aroused considerable interests, in part not only due to the relevant properties in such materials being usually very sensitive to pressure , but also due to the formation of polymeric nitrogen of these materials under high pressure and temperature . Since the first successful synthesis of polymeric nitrogen in nitrogen molecules, synthesis of stable polymeric nitrogen has become an attractive topic in experiment and theoretical study .…”

Flow chemistry as a versatile tool for the synthesis of triazoles

“…The microfluidic instrument relied on a stopped-flow profile rather than continuous operation, the Hessel and co-workers investigated the copper-free synthesis of the methyl ester precursor of Rufinamide in a high-pressure/high-temperature environment to achieve chemical intensification and to direct the selectivity. 109 The cycloaddition of 2,6-difluorobenzyl azide and methyl propiolate was explored in an autoclave batch reactor, specialized for the kilobar pressure range, and in a continuous-flow system equipped with a 400-bar BPR (Figure 22). …”

“…Fig.22Catalyst-free synthesis of a rufinamide precursor in a highpressure/high-temperature flow reactor 109. …”