Preserved priming across study-test picture transformations in patients with Alzheimer's disease.

Park, Sunghi M.; Gabrieli, John D. E.; Reminger, Sheryl L.; Monti, Laura A.; Fleischman, Debra; Wilson, Robert S.; Tinklenberg, Jared R.; Yesavage, Jerome A.

doi:10.1037/0894-4105.12.3.340

Cited by 32 publications

(32 citation statements)

References 54 publications

(75 reference statements)

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“…Structural similarity does not result in name confusion or delayed name latency [47]. Intact perceptual priming with pictures has also been found in DAT, indicating that high level perceptual representations are intact when accessed implicitly [11,36]. Having said this, there has been no previous direct attempt to relate performance on these tests of structural descriptions to anomia in DAT.…”

Section: Introductionmentioning

confidence: 96%

Loss of high-level perceptual knowledge of object structure in DAT

Done

Hajilou

2005

Neuropsychologia

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Visual object recognition and naming deficits in patients with dementia of the Alzheimer type (DAT) have typically been attributed to deficits in semantic processing. On a visual object naming test, a group of mild DAT patients were found to suffer from anomia, compared to an age-matched control group. DAT naming errors were typically within category (commission), associative or circumlocutory errors. Performance on tests of low level visuo-spatial ability fell within the normal range. Together these results suggested that anomia resulted from a dysfunctional semantic system with intact visual perception. However, in a naming task using visually degraded images of familiar objects, the recognition threshold in DAT patients was significantly higher, indicating the need for a more visually complete object representation, before it could be accurately recognised. In a matched task using words visually degraded in an identical manner, the recognition threshold for DAT patients was very similar to that of the control group. It is argued that these results support the idea that impaired structural descriptions of objects (i.e., pre-semantic representation of an object within the visual perceptual system) combines with degraded semantic representations to produce anomia in DAT.

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Section: Introductionmentioning

confidence: 96%

Loss of high-level perceptual knowledge of object structure in DAT

Done

Hajilou

2005

Neuropsychologia

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“…The dissociation between perceptual and word-retrieval processes may extend beyond object recognition to implicit memory processes. For example, forms of repetition priming that rely on structure-based processing (e.g., perceptual identification) are often intact in AD (Fleischman et al, 1995;Gabrieli et al, 1994;Keane et al, 1991Keane et al, , 1994, including picture-naming priming with stimuli overlapping with those used in the present study (Park et al, 1998). In contrast, kinds of repetition priming that rely on effortful retrieval (e.g., exemplar-generation priming) are often impaired in AD (Monti et al, 1996;Salmon et al, 1988).…”

Section: Discussionmentioning

confidence: 90%

Effects of structural similarity and name frequency on picture naming in Alzheimer's disease

Thompson-Schill

Gabrieli

Fleischman

1999

J Int Neuropsychol Soc

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Impairments to either perceptual or word-retrieval processes have been hypothesized to explain confrontation naming impairments in patients with Alzheimer's disease (AD). This study measured the effects of structural similarity, which affects perceptual processing, and name frequency, which affects word retrieval, on naming latency and accuracy in 16 AD patients and 16 age-matched controls. AD patients named pictures more slowly and made more errors than control participants. Their naming accuracy was disproportionately affected by name frequency, but not by structural similarity. The findings indicate that the processing of structural properties of objects is unaffected in early-stage AD, and suggest that word-retrieval impairments underlie the naming deficit in AD. (JINS, 1999, 5, 659-667.)

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“…While perceptual implicit memory seems to be relatively intact in patients with AD (Park et al, 1998; Fleischman, Wilson, Gabrieli, Schneider, Bienias, & Bennett, 2005), prior studies of conceptual implicit memory in patients with AD have been largely mixed (Gong, Tian, Cheng, Chen, Yin, Meng, et al, 2010; Fleischman et al, 2005; Fleischman, 2007). In general, tasks that require patients to utilize a cue to generate or produce a response often find impaired conceptual implicit memory, while tasks that require patients to identify previously presented stimuli often report intact conceptual implicit memory (Martins & Lloyd-Jones, 2006).…”

Section: Introductionmentioning

confidence: 99%

Preserved conceptual implicit memory for pictures in patients with Alzheimer’s disease

Deason

Hussey

Flannery

et al. 2015

Brain and Cognition

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The current study examined different aspects of conceptual implicit memory in patients with mild Alzheimer’s disease (AD). Specifically, we were interested in whether priming of distinctive conceptual features versus general semantic information related to pictures and words would differ for the mild AD patients and healthy older adults. In this study, 14 healthy older adults and 15 patients with mild AD studied both pictures and words followed by an implicit test section, where they were asked about distinctive conceptual or general semantic information related to the items they had previously studied (or novel items) Healthy older adults and patients with mild AD showed both conceptual priming and the picture superiority effect, but the AD patients only showed these effects for the questions focused on the distinctive conceptual information. We found that patients with mild AD showed intact conceptual picture priming in a task that required generating a response (answer) from a cue (question) for cues that focused on distinctive conceptual information. This experiment has helped improve our understanding of both the picture superiority effect and conceptual implicit memory in patients with mild AD in that these findings support the notion that conceptual implicit memory might potentially help to drive familiarity-based recognition in the face of impaired recollection in patients with mild AD.

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Preserved priming across study-test picture transformations in patients with Alzheimer's disease.

Cited by 32 publications

References 54 publications

Loss of high-level perceptual knowledge of object structure in DAT

Loss of high-level perceptual knowledge of object structure in DAT

Effects of structural similarity and name frequency on picture naming in Alzheimer's disease

Preserved conceptual implicit memory for pictures in patients with Alzheimer’s disease

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