Presepsin: A new marker of catheter related blood stream infections in pediatric patients

Başaranoğlu, Sevgen Tanır; Karadağ‐Öncel, Eda; Aykaç, Kübra; Özsürekçi, Yasemin; Aycan, Ahmet Emre; Cengiz, Ali Bülent; Kara, Ateş; Ceyhan, Mehmet

doi:10.1016/j.jiac.2017.08.012

Cited by 15 publications

(18 citation statements)

References 20 publications

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“…Thus, it was included as a separate study. Thus, four studies were included in our qualitative assessment and meta-analysis [38–40] (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…All eligible studies were published between 2016 and 2018. One was conducted in Turkey [38], one in Egypt [39], and two in Slovakia [40]. Three of them were prospective studies and one was retrospective.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies identified sepsis patients by positive bacterial cultures [39, 40]. One study [38] defined sepsis patients according to the criteria of the Infectious Diseases Society of America (IDSA) consensus conference (2009) [44]. Another study [40] designated sepsis patients based on the modified International Pediatric Sepsis Consensus Conference definition (IPSCC) (2005) [7].…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, presepsin could be a useful biomarker for the early diagnosis of sepsis. Several clinical studies [38–41] proposed the diagnostic value of presepsin in pediatric sepsis. However, there is no published meta-analysis of its diagnostic efficacy in pediatric sepsis patients.…”

Section: Introductionmentioning

confidence: 99%

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Presepsin as a diagnostic marker of sepsis in children and adolescents: a systemic review and meta-analysis

Yoon

Kim

et al. 2019

BMC Infect Dis

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Background: Early diagnosis of sepsis in pediatric patients is vital but remains a major challenge. Previous studies showed that presepsin is potentially a reliable diagnostic biomarker for sepsis in adult and neonates. However, there is no pooled analysis of its efficacy as a diagnostic biomarker for sepsis in children. The aims of the present meta-analysis were to assess the overall diagnostic accuracy of presepsin in pediatric sepsis and compare it to those for C-reactive protein (CRP) and procalcitonin (PCT). Methods: A systematic literature search was performed in Medline/Pubmed, Embase, the Cochrane Library, and ISI Web of Science to identify relevant studies reporting the diagnostic accuracy of presepsin in patients with pediatric sepsis. Sensitivities and specificities were pooled by bivariate meta-analysis. Heterogeneity was evaluated by χ 2 test. Results: We identified 129 studies in total. Most were disqualified on the basis of their titles/abstracts and duplication. Four studies were included in the final analysis. They comprised 308 patients aged between 1 mo and 18 y. The pooled diagnostic sensitivity and specificity of presepsin were 0.94 (95% confidence interval [CI]: 0.74-0.99) and 0.71 (95% CI: 0.35-0.92), respectively. The pooled diagnostic odds ratio, positive likelihood ratio (LR), and negative LR of presepsin were 32.87 (95% CI: 2.12-510.09), 3.24 (95% CI, 1.14-12.38), and 0.08 (95% CI, 0.01-0.74), respectively. Heterogeneity was found in both sensitivity (χ 2 = 11.17; P = 0.011) and specificity (χ 2 = 65.78; P < 0.001). No threshold effect was identified among the studies (r = − 0.938). The pooled sensitivity of presepsin (0.94) was higher than that of CRP (0.51) and PCT (0.76), whereas the overall specificity of presepsin (0.71) was lower than that of CRP (0.81) and PCT (0.76). The AUC of presepsin (0.925) was higher than that of CRP (0.715) and PCT (0.820). Conclusion: Currently available evidence indicates that presepsin has higher sensitivity and diagnostic accuracy, but lower specificity, than PCT or CRP in detecting sepsis in children. However, these results must be carefully interpreted as the number of studies included was small and the studies were statistically heterogeneous.

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“…Thus, it was included as a separate study. Thus, four studies were included in our qualitative assessment and meta-analysis [38–40] (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Presepsin as a diagnostic marker of sepsis in children and adolescents: a systemic review and meta-analysis

Yoon

Kim

et al. 2019

BMC Infect Dis

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“…According to a recent metaanalysis, presepsin showed high sensitivity and diagnostic accuracy in sepsis in children compared to CRP and PCT, but its specificity was lower. There was also a significant increase in presepsin concentration in children with suspected or registered catheter-associated infection compared to healthy children in the control group (45)(46)(47).…”

Section: Specific Diagnosis Of Sepsis and Septic Shock In Childrenmentioning

confidence: 86%

Modern Diagnostics of Sepsis and Septic Shock in Children

et al. 2020

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Sepsis is still one of the leading causes of child mortality worldwide, despite advances in its diagnosis and treatment. Difficulties in recognizing the transition of a localized infectious-inflammatory process to a generalized one lead to a belated diagnosis and the beginning of therapy. Meanwhile, the earlier treatment is started, the higher the patients' chances of life. Early diagnosis of sepsis, which corresponds to modern ideas about this condition, is one of the main tasks for both scientists and practitioners. The aim of this review is to study modern recommendations for the diagnosis of sepsis and septic shock in children. The article reflects the epidemiology, etiological features, modern definitions and methods of diagnosis of pediatric sepsis.

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Bedside ultrasound as a screening test for the diagnosis of catheter-related bloodstream infection (CRBI)

et al. 2021

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Purpose Between 15 and 30% of all nosocomial bacteremias and sepsis are associated with the use of intravascular devices. Catheter-related bloodstream infections (CRBI) are infections in which the organism identified in the blood is also present on the tip of the catheter itself or in a blood sample taken through it. The aim of the study was to evaluate the role of ultrasound in the diagnosis of infections related to the use of central catheters. Methods Between January 2018 and June 2019, we carried out a prospective study on 36 patients with a central catheter, such as a central venous catheter (CVC), a central catheter with peripheral insertion (PICC), or a fully implanted central venous catheter (PORT-a-cath) and who had signs and symptoms of infection. These patients were submitted to an ultrasound of the catheter upon arrival in the ward in case of suspected infection, or at the time of the onset of signs and symptoms of infection (if these arose during hospitalization). Patients with a central catheter but without signs and symptoms of infection were not included in the study. The end point of the study was to evaluate sensitivity (SENS), specificity (SPEC), positive and negative predictive value (PPV-NPV) and overall diagnostic accuracy (ODA) of ultrasound in the diagnosis of CRBI through Receiver Operating Characteristic (ROC) curve analysis. Results US showed a SENS of 94%, a SPEC of 84%, a PPV of 84%, an NPV of 94% and an ODA of 88.8% for the diagnosis of CRBI. Conclusions Preliminary data from our study show that US of intravascular devices has a high SENS and SPEC in the diagnosis of CRBI, and can, therefore, be used as a valid tool to decide whether to remove the device early or leave it in place.

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Presepsin: A new marker of catheter related blood stream infections in pediatric patients

Cited by 15 publications

References 20 publications

Presepsin as a diagnostic marker of sepsis in children and adolescents: a systemic review and meta-analysis

Presepsin as a diagnostic marker of sepsis in children and adolescents: a systemic review and meta-analysis

Modern Diagnostics of Sepsis and Septic Shock in Children

Bedside ultrasound as a screening test for the diagnosis of catheter-related bloodstream infection (CRBI)

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