Presentation and Progression of Childhood-Onset Inflammatory Bowel Disease in Northern Stockholm County

Abstract

Patients with childhood-onset IBD were characterized by extensive colitis that was relatively stable over time and associated with a relatively low risk of complications and abdominal surgery. Our findings confirm the more extensive disease location in pediatric IBD but did not identify the proposed dynamic and aggressive nature of the childhood-onset phenotype. The association of nonmucosal healing with a complicated disease course suggests that endoscopy should guide treatment intensity in childhood-onset CD.

Low colectomy rate five years after diagnosis of ulcerative colitis. Results from a prospective population-based cohort in Sweden (ICURE) diagnosed during 2005–2009*

“…[22] This contrasts to the experience from Canada, where pediatric patients were reported to be subjected to surgery in a frequency of 16.4% in a study demonstrating more surgery in low socioeconomic groups vs. high socioeconomic groups. [23] Similarly, a recent French study reports a surgery frequency of 20% after five years [24] and a report from our neighbor country Finland, where 25% were operated after five years [25] raising the question whether pediatric IBD patients display different phenotypes in different countries.…”

Systematic review with meta‐analysis: proximal disease extension in limited ulcerative colitis

“…After exclusion of duplicates, 4443 records were screened. After reviewing the title and abstract and if necessary the full publications, 41 relevant studies were retrieved for full review out of 139 full‐text articles were assessed for eligibility. Studies with no baseline endoscopic assessment, less than 13 cases or with insufficient information on patients were excluded.…”

“…Twelve of the 41 studies were abstracts and 27 were retrospective studies. Twenty‐four studies were from Europe, seven from North America, seven from Asia and one from Africa . Accrual period for these studies, reported in 38 studies of 41 ranged from 1953 to 2016.…”

“…Ulcerative colitis overall rate of extension was reported in 30 studies with information on rate of extension from proctitis (E1) to left side colitis (E2) in 11 studies from left side colitis (E2) to pancolitis (E3) in 13 studies and from proctitis (E1) to pancolitis (E3) in 10 studies Information on extension over time (at 5 and 10 years) was reported in 11 studies, of which 3 were not included in the meta‐analysis because of insufficient information.…”

Defining the ultrasound longitudinal natural history of newly diagnosed pediatric small bowel Crohn disease treated with infliximab and infliximab–azathioprine combination therapy

“…An estimated 25–30% of individuals with Crohn disease are diagnosed during childhood or adolescence, with involvement most commonly affecting the distal small bowel and colon [1–3]. Timely diagnosis and treatment of this condition is critical because misdiagnosis or under-treatment has been associated with significant co-morbidities, including impaired growth and failure to thrive, development of disease-related complications (e.g., intra-abdominal abscess and bowel obstruction), and overall reduced health-related quality of life [4–7].…”