Presence of very high prevalence and intensity of infection with Fasciola hepatica among Aymara children from the Northern Bolivian Altiplano

Esteban, J. Guillermo; Flores, Angela; Aguirre, C.; Strauss, W; Angles, René; Mas‐Coma, Santiago

doi:10.1016/s0001-706x(97)00669-4

Cited by 96 publications

(74 citation statements)

References 8 publications

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“…The fascioliasis prevalence in Chijipata Alta is the highest detected in humans by means of coprological techniques so far considering that, in this endemic region, coprology underestimates prevalences (Esteban et al 1997) by at least 15% compared to immunological procedures (Hillyer et al 1992), the resulting prevalence surpasses 80%. This confirms the very high prevalences (up to 90%) noted in local Bolivian papers (Cáceres Vega 1989; review by Mas-Coma et al 1995) and suggests the existence of hyperendemic subzones within the large human fascioliasis endemic zone of the Bolivian Northern Altiplano.…”

Section: Discussionmentioning

confidence: 98%

“…Egg shedding intensities (range, arithmetic and geometric means) also appear to be the highest known: 3000 to 4440 epg were only known in the community of Huacullani (where Յ5064 epg were found in a child) so far, in the same endemic region of the Bolivian Altiplano but further south (Esteban et al 1997). In the rest of the world, the highest intensities recorded were 450 epg in a Japanese subject (Akahane et al 1975) and Յ2100 epg in Portuguese subjects (Sampaio Silva in Chen & Mott 1990), although normal findings in coprological tests usually report 1-4 epg (Bendezu et al 1982;Knobloch et al 1985;Chen & Mott 1990).…”

Section: Discussionmentioning

confidence: 99%

“…The Bolivian Northern Altiplano, located at 3800-4200 m altitude between Lake Titicaca and the valley of the city of La Paz, is the geographical zone with the world's highest prevalences (Hillyer et al 1992;Mas-Coma et al 1995;Bjorland et al 1995;Esteban et al 1997) and intensities (Esteban et al 1996) of human infection by Fasciola hepatica (Linnaeus 1758) (Trematoda: Fasciolidae). This high endemicity is related to the introduction of the intermediate molluscan host Lymnaea truncatula (Müller 1774) (Gastropoda: Basommatophora: Lymnaeidae) imported long ago by Spanish colonizers Bargues & Mas-Coma 1997;Jabbour-Zahab et al 1997).…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, different subzones showing varying degrees of health impact of the disease were identified by means of surveys of school children (Esteban et al 1997).…”

Section: Introductionmentioning

confidence: 99%

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A population‐based coprological study of human fascioliasis in a hyperendemic area of the Bolivian Altiplano

Esteban

Flores

Angles³

et al. 1997

Tropical Med Int Health

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SummaryThe community of Chijipata Alta, at an altitude of 3850 m, near the southern coast of Lake Titicaca in the Northern Altiplano of Bolivia, was surveyed for human fascioliasis. The global prevalence (66.7%) and intensity (eggs per gram of faeces -epg: range: 24-4440; arithmetic mean: 1001; geometric mean: 390) proved to be the highest known in the world by means of coprological techniques. These results suggest the existence of highly hyperendemic subzones among the large human fascioliasis-endemic zone of the Bolivian Northern Altiplano. Despite the decrease in prevalence and intensity from children (75.0%, 24-4440 epg) to adults (41.7%, 144-864 epg), our findings show that in an hyperendemic zone adult subjects either maintain the parasites acquired when young or are newly infected as the consequence of inhabiting a zone of high infection risk.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Similarly, different subzones showing varying degrees of health impact of the disease were identified by means of surveys of school children (Esteban et al 1997).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A population‐based coprological study of human fascioliasis in a hyperendemic area of the Bolivian Altiplano

Esteban

Flores

Angles³

et al. 1997

Tropical Med Int Health

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“…In human parasitology, besides its demonstrated importance for the diagnosis of schistosomiasis (KATZ et al, 1972;WHO, 2013), the Kato-Katz method has also been used to diagnose fascioliasis (ESTEBAN et al, 1997;EL-MORSHEDY et al, 2002), clonorchiasis (CHOI et al, 2005), opisthorchiasis (SOUKHATHAMMAVONG et al, 2011;LOVIS et al, 2012) and dicrocoeliasis (ASHRAFI, 2010;TAY et al, 2011). However, the Kato-Katz method is still not widely used in the diagnosis of animal trematodiasis.…”

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confidence: 99%

Evaluation of Kato-Katz and spontaneous sedimentation methods for the diagnosis of platynosomiasis in Neotropical primates

Mati

Pinto

Melo

2015

Rev. Bras. Parasitol. Vet.

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Platynosomiasis is a parasitic infection reported in non-human primates, including marmosets, and is frequently difficult to diagnose. In this study, the Kato-Katz method and the spontaneous sedimentation method were evaluated for their usefulness in identifying Platynosomum eggs in fecal samples from Callithrix penicillata that naturally harbor Platynosomum illiciens. Spontaneous sedimentation allowed the diagnosis of 41.7% (5/12) and 66.7% (8/12) of infected marmosets from one and three slides, respectively, prepared from the same fecal sample. The examination of a single Kato-Katz thick smear detected 83.3% (10/12) of infection cases. The analysis of feces on three different days increased the rate of diagnosis, since 75% (9/12) and 100% (12/12) of the primates with platynosomiasis were identified using serial spontaneous sedimentation (3 slides/day) and the Kato-Katz method, respectively. The mean number of Platynosomum eggs per gram of feces determined via the Kato-Katz method was 71.7 (8-240). The spontaneous sedimentation method when performed in series is acceptable for the diagnosis of platynosomiasis. However, the Kato-Katz method, which was here used for the first time to detect this infection, has a higher diagnostic sensitivity and the advantage that a quantitative analysis of the eggs released in the host feces is possible.Keywords: Fecal parasitological diagnosis, platynosomiasis, Platynosomum, marmosets, spontaneous sedimentation, Kato-Katz thick smear. ResumoA platinossomose é uma infecção parasitária relatada em primatas não-humanos, inclusive saguis, cujo diagnóstico é frequentemente difícil. Neste estudo, os métodos de sedimentação espontânea e Kato-Katz foram avaliados quanto à sua utilidade na identificação de ovos de Platynosomum em amostras fecais de Callithrix penicillata naturalmente albergando Platynosomum illiciens. A sedimentação espontânea permitiu o diagnóstico de 41,7% (5/12) e 66,7% (8/12) dos saguis infectados a partir da análise de uma e três lâminas, respectivamente, preparadas de uma mesma amostra fecal. O exame de uma única lâmina de Kato-Katz detectou 83,3% (10/12) dos casos de infecção. A análise de fezes em três dias diferentes aumentou as taxas de diagnóstico, uma vez que 75% (9/12) e 100% (12/12) dos primatas que apresentaram a platinossomose foram identificados, usando-se a sedimentação espontânea (três lâminas/dia) e o Kato-Katz em série, respectivamente. O número médio de ovos de Platynosomum por g de fezes, determinado através do método de Kato-Katz, foi de 71,7 (8-240). O método de sedimentação espontânea, quando realizado em série, é aceitável para o diagnóstico da platinossomose. Entretanto, o método de Kato-Katz, o qual foi pela primeira vez usado para se detectar essa infecção, mostrou uma maior sensibilidade diagnóstica, com a vantagem de que é possível uma análise quantitativa dos ovos liberados nas fezes do hospedeiro.Palavras-chave: Diagnóstico parasitológico fecal, platinossomose, Platynosomum, saguis, sedimentação espontânea, Kato-Katz.

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Fasciola hepatica: Parasite-Secreted Proteinases Degrade All Human IgG Subclasses: Determination of the Specific Cleavage Sites and Identification of the Immunoglobulin Fragments Produced

Berasain¹,

Carmona²,

Frangione

et al. 2000

Experimental Parasitology

120

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Presence of very high prevalence and intensity of infection with Fasciola hepatica among Aymara children from the Northern Bolivian Altiplano

Cited by 96 publications

References 8 publications

A population‐based coprological study of human fascioliasis in a hyperendemic area of the Bolivian Altiplano

A population‐based coprological study of human fascioliasis in a hyperendemic area of the Bolivian Altiplano

Evaluation of Kato-Katz and spontaneous sedimentation methods for the diagnosis of platynosomiasis in Neotropical primates

Fasciola hepatica: Parasite-Secreted Proteinases Degrade All Human IgG Subclasses: Determination of the Specific Cleavage Sites and Identification of the Immunoglobulin Fragments Produced

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