volume 66, issue 9, P5691-5695 1992
DOI: 10.1128/jvi.66.9.5691-5695.1992
View full text

Abstract: The Duplan strain of murine leukemia virus induces murine AIDS in C57BV6 mice. When spleen cells from C57BL/6 mice infected with the virus were transplanted into nude mice, subcutaneous solid tumors at the transplanted sites were formed and splenomegaly and lymphadenopathy were induced. These transplantable cells were Thy-l CD4+ ct-1 T-celi receptor-positive T cells and integrated with the pathogenic defective viral genome. These results indicate that neoplastic cells of T-cell lineage were induced by infectin…

Expand abstract