Presence of p16 hypermethylation and Epstein–Barr virus infection in transplant-associated hematolymphoid neoplasm of the skin

Arbiser, Jack L.; Mann, Karen P.; Losken, Elizabeth M.; Cohen, Cynthia; Reddy, Kalpana K.; Kokko, Kenneth E.; Pollack, Brian P.; Fan, Chung-Yang; O’Reilly, Fiona

doi:10.1016/j.jaad.2006.06.043

Cited by 22 publications

(22 citation statements)

References 9 publications

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“…These tumors are very rare 53–55 : only a few cases were reported in immunodeficient patients, two secondary to Human immunodeficiency virus (HIV), 56,57 and five following renal transplant. All were EBV related and developed more than a year after transplant 17–20,27 …”

Section: Discussionmentioning

confidence: 99%

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Cutaneous presentation of post‐renal transplant lymphoproliferative disorder: a series of four cases

et al. 2010

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We report detailed histological and molecular characteristics of four post transplant lymphoproliferative disorders (PTLD) presenting in the skin of renal transplant patients, and their clinical outcome. Three had B-cell lymphomas (cases 1-3), and one had a T-cell lymphoma (case 4). All B-cell lymphomas showed Epstein-Barr virus (EBV) by immunohistochemistry (IHC) or in situ hybridization (ISH). Cases 1 and 2 were large cell lymphomas, and case 3 a plasmacytoma. Case 1 showed light chain restriction and heavy chain gene rearrangement by polymerase chain reaction (PCR). The patient was then diagnosed with an abdominal lymphoma and died of sepsis. Case 2 had no recoverable DNA. Case 3 had a plasmacytoma that showed monoclonal light chain restriction on IHC and an oligoclonal heavy chain rearrangement by PCR. In cases 2 and 3, the lesions regressed following reduction of immunosuppression, and died 1.5 and 8 years later from unrelated medical causes. Case 4 was a CD 30+ anaplastic large T-cell lymphoma with no EBV detected by IHC, ISH and PCR, and died of heart failure 2 years later. Cutaneous manifestations of PTLD are rare, show wide array of clinical and pathological features, and generally have a favorable prognosis. EBV appears to be associated only with B-cell cutaneous lymphomas.

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Section: Discussionmentioning

confidence: 99%

“…Approximately 5% of PTLDs will involve the skin 4,6,16 . All cases of cutaneous PTLD in renal transplant patients described in the literature are summarized in Table 1 17–27 .…”

Section: Literature Reviewmentioning

confidence: 99%

Cutaneous presentation of post‐renal transplant lymphoproliferative disorder: a series of four cases

et al. 2010

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“…We subsequently discovered that carcinogens that induce reactive oxygen (insoluble nickel) cause tumors with hypermethylation of p16ink4a [19]. Careful examination of the literature demonstrates that virtually all tumors that are caused by reactive oxygen, including chronic inflammation, results in hypermethylation of p16ink4a [20]. These include all tumors caused by Epstein–Barr virus (EBV; Burkitt’s lymphoma [BL], Hodgkin’s disease and gastric carcinoma), hepatitis C virus (hepatocellular carcinoma), ultraviolet A (melanoma), inflammatory bowel disease-induced colon carcinoma, schistosomiasis-induced bladder cancer, tobacco-induced oral and lung carcinoma and epidermolysis bullosa-associated squamous cell carcinoma [21–24].…”

Section: Definition Of the Reactive Oxygen-driven Tumormentioning

confidence: 99%

The antioxidant paradox: what are antioxidants and how should they be used in a therapeutic context for cancer

Bonner

Arbiser

2014

Future Medicinal Chemistry

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So-called antioxidants have yet to make a clinical impact on the treatment of human cancer. The reasons for this failure are several. First, many agents that are called antioxidants are truly antioxidants at a given dose, but this dose may not have been given in clinical trials. Second, many agents are not antioxidants at all. Third, not all tumors use reactive oxygen as a signaling mechanism. Finally, reactive oxygen inhibition is often insufficient to kill or regress a tumor cell by itself, but requires sequential introduction of a therapeutic agent for maximal effect. We hope to provide a framework for the logical use of these agents in cancer.

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“…250,268,269 Primary cutaneous PTLD has also been reported in the literature, 58,255,[270][271][272][273][274][275][276][277][278][279][280][281][282][283] including B-cell and T-cell lymphomas. 250,268,269 Primary cutaneous PTLD has also been reported in the literature, 58,255,[270][271][272][273][274][275][276][277][278][279][280][281][282][283] including B-cell and T-cell lymphomas.…”

Section: Ebv-positive Lymphomas In the Context Of Immunosuppression Pmentioning

confidence: 99%

“…280,284,285 Some of the cases showed a HL-like appearance. [273][274][275][276]282 Also a case of biclonal EBV-associated PTLD with distinct T-cell and B-cell clones has been published 262 ; the T-cell component resembled a HL with Reed-Sternberglike cells and the B-cell component was plasma cell rich. [273][274][275][276]282 Also a case of biclonal EBV-associated PTLD with distinct T-cell and B-cell clones has been published 262 ; the T-cell component resembled a HL with Reed-Sternberglike cells and the B-cell component was plasma cell rich.…”

Section: Ebv-positive Lymphomas In the Context Of Immunosuppression Pmentioning

confidence: 99%

Epstein–Barr Virus in Cutaneous Pathology

Fernández-Flores

2013

The American Journal of Dermatopathology

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Epstein-Barr virus (EBV) is a ubiquitous double-stranded DNA gamma herpes virus and it is present in 95% of adults. EBV infection is seen in many oncological conditions, although there is controversy regarding whether EBV is causative, a cofactor, or just a coincidental infection. Some of these conditions involve the skin as the main or as a secondary organ. In this report, we review several tumoral and nontumoral cutaneous conditions, which are related to EBV infection, and describe the epidemiology of infection and the life cycle of the virus.

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Presence of p16 hypermethylation and Epstein–Barr virus infection in transplant-associated hematolymphoid neoplasm of the skin

Cited by 22 publications

References 9 publications

Cutaneous presentation of post‐renal transplant lymphoproliferative disorder: a series of four cases

Cutaneous presentation of post‐renal transplant lymphoproliferative disorder: a series of four cases

The antioxidant paradox: what are antioxidants and how should they be used in a therapeutic context for cancer

Epstein–Barr Virus in Cutaneous Pathology

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