2014
DOI: 10.1016/j.jped.2013.12.006 View full text |Buy / Rent full text
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Abstract: even with high sensitivity methods, newborns with congenital toxoplasmosis can have negative Toxo-IgM at birth. In those who have these antibodies, the positive period may be quite short. It is important not to interrupt the monitoring of infants with suspected congenital toxoplasmosis simply because they present a negative Toxo-IgM result.

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“…These data reinforce the importance of pediatric followups. 3,4,20,30,31 In the present study, the cases of miscarriage due to congenital infection by the parasite, of gestational loss, and of premature rupture of membranes were not observed as complications of having performed amniocentesis. It is known that such an invasive procedure in fetal medicine presents a rate of 1% of risks of complications.…”
Section: Discussionmentioning
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“…These data reinforce the importance of pediatric followups. 3,4,20,30,31 In the present study, the cases of miscarriage due to congenital infection by the parasite, of gestational loss, and of premature rupture of membranes were not observed as complications of having performed amniocentesis. It is known that such an invasive procedure in fetal medicine presents a rate of 1% of risks of complications.…”
Section: Discussionmentioning
“…Detection of T. gondii DNA by molecular methods is quite controversial as there are several techniques and markers to identify the DNA of the parasite, and there is no consensus on which protocol is the best. Moreover, the treatment of pregnant women can modify the results of serological and molecular tests, as has been described by some authors (Lago et al, 2014;Lefevre-Pettazzoni et al, 2007;McLeod, 2014;Okay et al, 2009;Robert-Gangneux and Dardé, 2012).…”
Section: Discussionmentioning
“…In addition, the clinical manifestations of toxoplasmosis in newborns include hepatosplenomegaly, jaundice, lymphadenomegaly, thrombocytopenia, and anemia [46,47]. The positive period may be quite short in newborns with anti- Toxoplasma IgM; in addition, newborns with CT can have negative anti- Toxoplasma IgM at birth [48]. In a study conducted by Alameh & Tavangar [24], 7 newborns with anti- Toxoplasma IgG did not have the IgM antibodies; however, only 1 neonate had microcephaly and hypotony.…”
Section: Discussionmentioning