Prereproductive Stress to Female Rats Alters Corticotropin Releasing Factor Type 1 Expression in Ova and Behavior and Brain Corticotropin Releasing Factor Type 1 Expression in Offspring

Zaidan, Hiba; Leshem, Micah; Gaisler‐Salomon, Inna

doi:10.1016/j.biopsych.2013.04.014

Cited by 77 publications

(84 citation statements)

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“…Animal studies have elucidated an additional route for transmission of pre-conception stress effects via epigenetic alterations in stress substrates in the mother's brain and ova, and subsequent alterations in offspring behavior, endocrine and brain microstructure (Bock et al 2014;Franklin et al 2010;Zaidan et al 2013;Zaidan and Gaisler-Salomon 2015). The effects differ in male and female offspring, but the consistent finding that neonates born to preconception stressed dams already show alterations in brain functioning suggests that, at least in experimental rats, the changes in offspring behavior cannot be exclusively explained by alterations in nurturing ascribed to the mother's stress experience.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the period of stress was sharply demarcated, its characteristics circumscribed and consistent. Building upon animal studies that demonstrate the effects of maternal pre-conception stress on offspring adjustment (Bock et al 2014;Leshem and Schulkin 2012;McGown and Roth 2015;Shachar-Dadon et al 2009;Zaidan et al 2013), and applying a bioecological framework (PPCT ;Bronfenbrenner 2005), the current study examined the links between war exposure and maternal emotional distress during the 2006 Lebanon war and subsequent mother and child adjustment among mothers who conceived 1-12 months after the war. Unlike previous studies in which both mothers and children were directly exposed to war, making it difficult to disentangle effects of direct exposure versus intergenerational transmission and effects that parents and children may have on each other, the current study focused on children who were not directly exposed to war experiences in utero or neonatally.…”

Section: The Current Studymentioning

confidence: 99%

“…An important expansion of these studies would be to examine whether maternal exposure to major stress prior to conception, wherein the offspring is not directly exposed as either a fetus or neonate, can affect postnatal development. Animal studies have shown that pre-conception exposure to mild stress in adolescent female rats is related to behavioral alterations that extend to the offspring, and has cross-generational effects on endocrine and brain function (Bock et al 2014;Leshem and Schulkin 2012;McGown and Roth 2015;Shachar-Dadon et al 2009), with a possible contribution of epigenetic alterations to maternal ova (Zaidan et al 2013). In the current study, we examine transgenerational effects of pre-conception stress among humans.…”

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confidence: 99%

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Pre-Conception War Exposure and Mother and Child Adjustment 4 Years Later

Shachar-Dadon

Gueron‐Sela

Weintraub

et al. 2016

J Abnorm Child Psychol

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Evidence is accumulating for the transgenerational effects of maternal stress on offspring. A particular increasing concern is the possible transgenerational effects of community exposure to war and terror. Here, 107 mothers that had been exposed to war, were assessed with their 3 year old children (52 % girls) who had been conceived after the end of the war, and thus never directly exposed to war. The circumscribed nature (missile bombardment) and temporal limits (34 days) of the tragic 2006 Lebanon war in the north of Israel, affords a unique methodological opportunity to isolate an epoch of stress from preceding and subsequent normal life. We find that war experience engenders higher levels of mothers' separation anxiety, lower emotional availability in mother-child interaction, and lower levels of children's adaptive behavior. The novelty of these findings lies in documenting the nature and strength of transgenerational effects of war-related stress on offspring that were never exposed. In addition, because these effects were obtained after 4 years of a continuing period of normality, in which the children were born and raised, it suggests that an extended period of normality does not obliterate the effects of the war on mother and child behavior as assessed herein. Despite the study limitations, the results are indicative of persisting transgenerational effects of stress.

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Section: Discussionmentioning

confidence: 99%

Section: The Current Studymentioning

confidence: 99%

mentioning

confidence: 99%

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Pre-Conception War Exposure and Mother and Child Adjustment 4 Years Later

Shachar-Dadon

Gueron‐Sela

Weintraub

et al. 2016

J Abnorm Child Psychol

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“…RNA extraction and cDNA preparation were performed using standard methodology, as previously described (Zaidan et al, 2013). mRNA gene expression levels of C-fos were determined by real-time quantitative PCR (qRT-PCR), using SYBR-Green fluorometric-based detection as previously described (Zaidan et al, 2013).…”

Section: Biochemical Methodsmentioning

confidence: 99%

“…mRNA gene expression levels of C-fos were determined by real-time quantitative PCR (qRT-PCR), using SYBR-Green fluorometric-based detection as previously described (Zaidan et al, 2013). Primers were designed using Primer Express (Applied Biosystems, Foster City, CA) and generated by Integrated DNA Technologies (Coralville, IA).…”

Section: Biochemical Methodsmentioning

confidence: 99%

Cannabinoids and Glucocorticoids in the Basolateral Amygdala Modulate Hippocampal–Accumbens Plasticity After Stress

Segev

Akirav

2015

Neuropsychopharmacol

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Acute stress results in release of glucocorticoids, which are potent modulators of learning and plasticity. This process is presumably mediated by the basolateral amygdala (BLA) where cannabinoids CB1 receptors have a key role in regulating the hypothalamic-pituitaryadrenal (HPA) axis. Growing attention has been focused on nucleus accumbens (NAc) plasticity, which regulates mood and motivation. The NAc integrates affective and context-dependent input from the BLA and ventral subiculum (vSub), respectively. As our previous data suggest that the CB1/2 receptor agonist WIN55,212-2 (WIN) and glucocorticoid receptor (GR) antagonist RU-38486 (RU) can prevent the effects of stress on emotional memory, we examined whether intra-BLA WIN and RU can reverse the effects of acute stress on NAc plasticity. Bilateral, ipsilateral, and contralateral BLA administration of RU or WIN reversed the stress-induced impairment in vSub-NAc long-term potentiation (LTP) and the decrease in cAMP response element-binding protein (CREB) activity in the NAc. BLA CB1 receptors were found to mediate the preventing effects of WIN on plasticity, but not the preventing effects of RU, after stress. Inactivating the ipsilateral BLA, but not the contralateral BLA, impaired LTP. The possible mechanisms underlying the effects of BLA on NAc plasticity are discussed; the data suggest that BLA-induced changes in the NAc may be mediated through neural pathways in the brain's stress circuit rather than peripheral pathways. The results suggest that glucocorticoid and cannabinoid systems in the BLA can restore normal function of the NAc and hence may have a central role in the treatment of a variety of stress-related disorders.

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Chronic social instability in adult female rats alters social behavior, maternal aggression and offspring development

Pittet

Babb

Carini

et al. 2017

Developmental Psychobiology

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We investigated the consequences of chronic social instability (CSI) during adulthood on social and maternal behavior in females and social behavior of their offspring in a rat model. CSI consisted of changing the social partners of adult females every 2-3 days for 28 days, 2 weeks prior to mating. Females exposed to CSI behaved less aggressively and more pro-socially towards unfamiliar female intruders. Maternal care was not affected by CSI in a standard testing environment, but maternal behavior of CSI females was less disrupted by a male intruder. CSI females were quicker to attack prey and did not differ from control females in their saccharin consumption indicating, respectively, no stress-induced sensory-motor or reward system impairments. Offspring of CSI females exhibited slower growth and expressed more anxiety in social encounters. This study demonstrates continued adult vulnerability to social challenges with an impact specific to social situations for mothers and offspring.

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Prereproductive Stress to Female Rats Alters Corticotropin Releasing Factor Type 1 Expression in Ova and Behavior and Brain Corticotropin Releasing Factor Type 1 Expression in Offspring

Cited by 77 publications

References 50 publications

Pre-Conception War Exposure and Mother and Child Adjustment 4 Years Later

Pre-Conception War Exposure and Mother and Child Adjustment 4 Years Later

Cannabinoids and Glucocorticoids in the Basolateral Amygdala Modulate Hippocampal–Accumbens Plasticity After Stress

Chronic social instability in adult female rats alters social behavior, maternal aggression and offspring development

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