PREPARATIVE ISOLATION AND PURIFICATION OF FOUR FLAVONOIDS FROM <i>DAPHNE GENKWA</i> SIEB. ET ZUCC. BY HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY

Xie, Huichun; Liang, Yong; Ito, Yoichiro; Wang, Xiaohong; Chen, Renshan; He, Juan; Li, Hang; Zhang, Tianyou

doi:10.1080/10826076.2011.589094

Cited by 27 publications

(12 citation statements)

References 20 publications

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“…The use of modern extractive approaches, such as dynamic maceration process [ 32 ] or ionic liquid analogs (deep eutectic solvents) as extractive solvents [ 33 ], negative pressure cavitation-assisted extraction with macroporous resin enrichment [ 30 ], microwave-assisted extraction, high-speed countercurrent chromatography [ 34 ], etc. should be explored to find an effective preparative method for the isolation and purification of flavonoids from E. horridum .…”

Section: Resultsmentioning

confidence: 99%

On the Physicochemical Characteristics and Applications of an “Undesirable” Pyrenean Thorny Cushion Dwarf: Echinospartum horridum (Vahl) Roth

Martín-Ramos

Martín‐Gil

Gómez

et al. 2020

Plants

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Small evergreen shrubs of the family Fabaceae represent a large proportion of current Mediterranean mountain vegetation. Their low pastoral value and tendency for encroachment makes these plants undesirable. In this paper, the thermal and chemical characteristics of Echinospartum horridum, a thorny cushion-shaped dwarf shrub native to the French Central Massif and the Pyrenees (particularly dominant in the shrublands of the Pyrenees), have been analyzed with a view to its valorization. Although the higher and lower heating values of the biomass from E. horridum met the ISO 17225-2:2014 requirements for its use in pellets, the ash content was slightly above the upper limit, so it would not comply with the normative for its acceptable use as a fuel. Nevertheless, the presence of high added-value flavonoids and lignans in its extracts, which are receiving increasing recent interest as efficient anti-tumor drugs and antivirals, may open the door to the valorization of this shrub for pharmacological applications.

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Section: Resultsmentioning

confidence: 99%

On the Physicochemical Characteristics and Applications of an “Undesirable” Pyrenean Thorny Cushion Dwarf: Echinospartum horridum (Vahl) Roth

Martín-Ramos

Martín‐Gil

Gómez

et al. 2020

Plants

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“…Although the IC50 were much higher, these observations are relevant to drug interaction because apigenin occurs in the apigenin-containing food or herb at comparable levels. For example, the level of apigenin in the extracts of Daphne genkwa can reach levels as high as 172 mg/kg [28] . Such concentrations of apigenin have the potential to affect human CYP2C9 and rat CYP2C11 activity.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of Apigenin on Losartan Metabolism and CYP2C9 Activity in vitro

Wang

Gong²,

Zeng³

et al. 2016

Pharmacology

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Background: CYP2C9 is one of the most important phase I drug-metabolizing enzymes in liver. The objective of this work was to investigate the effects of apigenin on the metabolism of losartan and human CYP2C9 and rat CYP2C11 activity in vitro. Methods: Different concentrations of apigenin were added to a 100 mmol/l Tris-HCl reaction mixture containing 2 pmol/ml recombinant human CYP2C9.1, 0.25 mg/ml human liver microsomes or 0.5 mg/ml rat liver microsomes to determine the half maximal inhibition or a half-maximal inhibitory concentration (IC50) on the metabolism of losartan. In addition, diclofenac used as CYP2C9 substrate was performed to determine the effects of apigenin on CYP2C9. Results: The results showed that apigenin has the inhibitory effect on the metabolism of losartan in vitro, the IC50 was 7.61, 4.10 and 11.07 μmol/l on recombinant CYP2C9 microsomes, human liver microsomes and rat liver microsomes, respectively. Meanwhile, apigenin's mode of action on human CYP2C9 activity was competitive for the substrate diclofenac. In contrast to its potent inhibition of CYP2C9 in humans (9.51 μmol/l), apigenin had lesser effects on CYP2C11 in rat (IC50 = 15.51 μmol/l). Conclusion: The observations imply that apigenin has the inhibitory effect on the metabolism of losartan and CYP2C9 activity in vitro. More attention should be paid as to when losartan should be administrated combined with apigenin.

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“…Specifically, casticin is isolated from the leaves [30][31][32] and fruits [30,33,34] of V. trifolia and V. negundo. The compound can also be isolated from various other plant species, including Psiada trinervia [35], Daphne genkwa [36] and Pluchea quitoc [37], to name a few. [29].…”

Section: Chemistrymentioning

confidence: 99%

An Overview of the Potential Antineoplastic Effects of Casticin

et al. 2020

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Cancer persists as one of the leading causes of deaths worldwide, contributing to approximately 9.6 million deaths per annum in recent years. Despite the numerous advancements in cancer treatment, there is still abundant scope to mitigate recurrence, adverse side effects and toxicities caused by existing pharmaceutical drugs. To achieve this, many phytochemicals from plants and natural products have been tested against cancer cell lines in vivo and in vitro. Likewise, casticin, a flavonoid extracted from the Vitex species, has been isolated from the leaves and seeds of V. trifolia and V. agnus-castus. Casticin possesses a wide range of therapeutic properties, including analgesic, anti-inflammatory, antiangiogenic, antiasthmatic and antineoplastic activities. Several studies have been conducted on the anticancer effects of casticin against cancers, including breast, bladder, oral, lung, leukemia and hepatocellular carcinomas. The compound inhibits invasion, migration and proliferation and induces apoptosis (casticin-induced, ROS-mediated and mitochondrial-dependent) and cell cycle arrest (G0/G1, G2/M, etc.) through different signaling pathways, namely the PI3K/Akt, NF-κB, STAT3 and FOXO3a/FoxM1 pathways. This review summarizes the chemo-preventive ability of casticin as an antineoplastic agent against several malignancies.

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PREPARATIVE ISOLATION AND PURIFICATION OF FOUR FLAVONOIDS FROM DAPHNE GENKWA SIEB. ET ZUCC. BY HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY

Cited by 27 publications

References 20 publications

On the Physicochemical Characteristics and Applications of an “Undesirable” Pyrenean Thorny Cushion Dwarf: Echinospartum horridum (Vahl) Roth

On the Physicochemical Characteristics and Applications of an “Undesirable” Pyrenean Thorny Cushion Dwarf: Echinospartum horridum (Vahl) Roth

Inhibitory Effect of Apigenin on Losartan Metabolism and CYP2C9 Activity in vitro

An Overview of the Potential Antineoplastic Effects of Casticin

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