Preparation, optimization and application of poly(ethylene glycol)methyl ether methacrylate/urethane methacrylate as a new polar phase for stir bar sorptive extraction

Rostami, Simindokht; Talebpour, Zahra; Yeganeh, Hamid

doi:10.1039/c4ay01113a

Cited by 8 publications

(1 citation statement)

References 45 publications

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“…Due to hydrophobic nature of PDMS‐based stir bars, there was a limitation on the application of polar compound extraction. In recent years, there has been a growing interest in development of new commercial stir bars and in‐house coatings for SBSE to improve their polarity, selectivity, and stability . Several SBSE‐related reviews have been reported, mainly focusing on preparation of different coatings .…”

Section: Introductionmentioning

confidence: 99%

Preparation of a novel sorptive stir bar based on vinylpyrrolidone‐ethylene glycol dimethacrylate monolithic polymer for the simultaneous extraction of diazepam and nordazepam from human plasma

Torabizadeh

Talebpour

Adib

et al. 2016

J of Separation Science

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A new monolithic coating based on vinylpyrrolidone-ethylene glycol dimethacrylate polymer was introduced for stir bar sorptive extraction. The polymerization step was performed using different contents of monomer, cross-linker and porogenic solvent, and the best formulation was selected. The quality of the prepared vinylpyrrolidone-ethylene glycol dimethacrylate stir bars was satisfactory, demonstrating good repeatability within batch (relative standard deviation < 3.5%) and acceptable reproducibility between batches (relative standard deviation < 6.0%). The prepared stir bar was utilized in combination with ultrasound-assisted liquid desorption, followed by high-performance liquid chromatography with ultraviolet detection for the simultaneous determination of diazepam and nordazepam in human plasma samples. To optimize the extraction step, a three-level, four-factor, three-block Box-Behnken design was applied. Under the optimum conditions, the analytical performance of the proposed method displayed excellent linear dynamic ranges for diazepam (36-1200 ng/mL) and nordazepam (25-1200 ng/mL), with correlation coefficients of 0.9986 and 0.9968 and detection limits of 12 and 10 ng/mL, respectively. The intra- and interday recovery ranged from 93 to 106%, and the relative standard deviations were less than 6%. Finally, the proposed method was successfully applied to the analysis of diazepam and nordazepam at their therapeutic levels in human plasma. The novelty of this study is the improved polarity of the stir bar coating and its application for the simultaneous extraction of diazepam and its active metabolite, nordazepam in human plasma sample. The method was more rapid than previously reported stir bar sorptive extraction techniques based on monolithic coatings, and exhibited lower detection limits in comparison with similar methods for the determination of diazepam and nordazepam in biological fluids.

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Section: Introductionmentioning

confidence: 99%

Preparation of a novel sorptive stir bar based on vinylpyrrolidone‐ethylene glycol dimethacrylate monolithic polymer for the simultaneous extraction of diazepam and nordazepam from human plasma

Torabizadeh

Talebpour

Adib

et al. 2016

J of Separation Science

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Sorptive thin film microextraction followed by direct solid state spectrofluorimetry: A simple, rapid and sensitive method for determination of carvedilol in human plasma

Karimi

Talebpour

Adib

2016

Analytica Chimica Acta

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Recent advances in stir-bar sorptive extraction: Coatings, technical improvements, and applications

Hasan

Ghiasvand

Lewis

et al. 2020

Analytica Chimica Acta

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Preparation, optimization and application of poly(ethylene glycol)methyl ether methacrylate/urethane methacrylate as a new polar phase for stir bar sorptive extraction

Abstract: The aim of this paper is to discuss the determination of carbaryl in a water sample using a stir bar sorptive extraction method based on a new polar extraction phase coupled with HPLC-DAD.

Cited by 8 publications

References 45 publications

Preparation of a novel sorptive stir bar based on vinylpyrrolidone‐ethylene glycol dimethacrylate monolithic polymer for the simultaneous extraction of diazepam and nordazepam from human plasma

Preparation of a novel sorptive stir bar based on vinylpyrrolidone‐ethylene glycol dimethacrylate monolithic polymer for the simultaneous extraction of diazepam and nordazepam from human plasma

Sorptive thin film microextraction followed by direct solid state spectrofluorimetry: A simple, rapid and sensitive method for determination of carvedilol in human plasma

Recent advances in stir-bar sorptive extraction: Coatings, technical improvements, and applications

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