Adrian Weisz, Jacob J. Witten, Yun Zeng, Eugene P. Mazzola, Yoichiro Ito
The present work describes the preparation of two compounds considered to be likely precursors of an impurity present in samples of the color additives D&C Red No. 27 (Colour Index 45410:1) and D&C Red No. 28 (Colour Index 45410, phloxine B) submitted to the U.S. Food and Drug Administration for batch certification. The two compounds, 2-(2′,4′-dihydroxy-3′-bromobenzoyl)-3,4,5,6-tetrachlorobenzoic acid (3BrHBBA) and its 5′-brominated positional isomer (5BrHBBA), both not reported previously, were separated fro…
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