Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2012.03.040 View full text
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Adrian Weisz, Jacob J. Witten, Yun Zeng, Eugene P. Mazzola, Yoichiro Ito

Abstract: The present work describes the preparation of two compounds considered to be likely precursors of an impurity present in samples of the color additives D&C Red No. 27 (Colour Index 45410:1) and D&C Red No. 28 (Colour Index 45410, phloxine B) submitted to the U.S. Food and Drug Administration for batch certification. The two compounds, 2-(2′,4′-dihydroxy-3′-bromobenzoyl)-3,4,5,6-tetrachlorobenzoic acid (3BrHBBA) and its 5′-brominated positional isomer (5BrHBBA), both not reported previously, were separated fro…

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