Preparation of spherical porous hydrogel beads based on ion-crosslinked gum tragacanth and graphene oxide: Study of drug delivery behavior

Rahmani, Zeinab; Sahraei, Razieh; Ghaemy, Mousa

doi:10.1016/j.carbpol.2018.04.022

Cited by 75 publications

(17 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cytotoxicity analysis has shown that 98% of cells survive at a bead concentration <125 µg/mL. The GO in the hydrogel caused an increase in swelling and capture efficiency and ensured the controlled release of the entrapped drug [151].…”

Section: Figure 11mentioning

confidence: 99%

Graphenic Materials for Biomedical Applications

2019

View full text Add to dashboard Cite

Graphene-based nanomaterials have been intensively studied for their properties, modifications, and application potential. Biomedical applications are one of the main directions of research in this field. This review summarizes the research results which were obtained in the last two years (2017-2019), especially those related to drug/gene/protein delivery systems and materials with antimicrobial properties. Due to the large number of studies in the area of carbon nanomaterials, attention here is focused only on 2D structures, i.e. graphene, graphene oxide, and reduced graphene oxide.

show abstract

Section: Figure 11mentioning

confidence: 99%

Graphenic Materials for Biomedical Applications

2019

View full text Add to dashboard Cite

show abstract

“…The adsorption percentages for without RGO were 70.6% and 20.4% for Hg 2+ and Cr 6+ respectively. The adsorption percentages for Hg 2+ ( Figure 6 a) and Cr 6+ ( Figure 6 b) ions were enhanced on raising the concentration of RGO from 0.005 g to 0.020 g. The RGO contains carboxylic groups which boost interactions with metal ions resulting in high percentage adsorption [ 30 ]. The removal efficiency of Hg 2+ and Cr 6+ was 90.7% and 38.4% at RGO loading of 0.020 g. The development of tough three-dimensional networks was responsible for the decrease in adsorption percentage at higher RGO loading (>0.020).…”

Section: Resultsmentioning

confidence: 99%

“…The shifting of -C-O stretching from 1128 cm −1 to 1125 cm −1 in GT-cl-poly(DMA)/RGO hydrogel composite is related to the successful incorporation of RGO in GT-cl-poly(DMA) hydrogel. The bands at 1638 cm −1 and 1748 cm −1 correspond to asymmetric stretching of the carboxylate group and asymmetric stretching of C=O in galacturonic acid respectively [30], peak at 1142 cm −1 ascribed to antisymmetric vibrations of C-O-C linkage in glycosidic groups [31]. The asymmetric stretching of C=O shows shifting of peaks from 1748 cm −1 to 1750 cm −1 after the crosslinking of poly(DMA).…”

Section: Ftirmentioning

confidence: 98%

Microwave-Assisted Rapid Synthesis of Reduced Graphene Oxide-Based Gum Tragacanth Hydrogel Nanocomposite for Heavy Metal Ions Adsorption

et al. 2020

View full text Add to dashboard Cite

Reduced graphene oxide (RGO) was synthesized in this research via Tour’s method for the use of filler in the hydrogel matrix. The copolymerization of N,N-dimethylacrylamide (DMA) onto the gum tragacanth (GT) was carried out to develop gum tragacanth-cl-N,N-dimethylacrylamide (GT-cl-poly(DMA)) hydrogel using N,N'-methylenebisacrylamide (NMBA) and potassium persulfate (KPS) as cross-linker and initiator correspondingly. The various GT-cl-poly(DMA) hydrogel synthesis parameters were optimized to achieve maximum swelling of GT-cl-poly(DMA) hydrogel. The optimized GT-cl-poly(DMA) hydrogel was then filled with RGO to form reduced graphene oxide incorporated gum tragacanth-cl-N,N-dimethylacrylamide (GT-cl-poly(DMA)/RGO) hydrogel composite. The synthesized samples were used for competent adsorption of Hg2+ and Cr6+ ions. Fourier transform infrared, X-ray powder diffraction, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy were used to characterize the gum tragacanth-cl-N,N-dimethylacrylamide hydrogel and reduced graphene oxide incorporated gum tragacanth-cl-N,N-dimethylacrylamide hydrogel composite. The experiments of adsorption-desorption cycles for Hg2+ and Cr6+ ions were carried out to perform the reusability of gum tragacanth-cl-N,N-dimethylacrylamide hydrogel and reduced graphene oxide incorporated gum tragacanth-cl-N,N-dimethylacrylamide hydrogel composite. From these two samples, reduced graphene oxide incorporated gum tragacanth-cl-N,N-dimethylacrylamide exhibited high adsorption ability. The Hg2+ and Cr6+ ions adsorption by gum tragacanth-cl-N,N-dimethylacrylamide and reduced graphene oxide incorporated gum tragacanth-cl-N,N-dimethylacrylamide were best suited for pseudo-second-order kinetics and Langmuir isotherm. The reported maximum Hg2+ and Cr6+ ions adsorption capacities were 666.6 mg g-1 and 473.9 mg g-1 respectively.

show abstract

“…As the clinical drug for NPC therapy, DOC was loaded on Tf-HPAA-GO to form the Tf-HPAA-GO/DOC complex through the π-π interactions between GO and DOC. It has been reported that the drugs containing benzene groups could stack on the GO plane effectively, so GO showed higher drugs loading amount than micelles and other usual carriers (Ma et al., 2012; Rahmani et al., 2018; Liu et al., 2018). In this work, the loading amount of DOC in Tf-HPAA-GO/DOC complex was determined as 5.6% (w/w) by HPLC analysis, much higher than our previous work (Liu et al., 2016).…”

Section: Resultsmentioning

confidence: 99%