Preparation of sodium chromate-51Cr and chromic chloride-51Cr for medical applications

Karim, H. M. A.

doi:10.1016/0020-708x(73)90129-4

Cited by 9 publications

(4 citation statements)

References 8 publications

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“…. NPy)*HCr04- (2) or through the formation of the mixed quadrupoles formed by the association of the free amine nitrate with the chro- C^Cb2-is negligibly small (7), there is no possibility for their extraction. The influence of the concentration of chromium (VI) on the extraction from 0.25, 3, and 5M nitric acid by 0.1M NPy/benzene was studied.…”

Section: Resultsmentioning

confidence: 99%

“…Department of Chemistry, Indian Institute of Technology, Bombay, Powai, Bombay 400 076, india Hydroxamic acids are the potential reagents for the determination of vanadium(V) (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). The parent acid Nphenylbenzohydroxamic acid (PBHA) (I) is a selective and (o)-N-OH <o>-C=0 (I) sensitive reagent for vanadium(V) having a maximum absorbance at 530 nm; e = 4650 of chloroform extract of vanadate complex (4).…”

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confidence: 99%

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Extraction and separation studies of chromium(VI) from nitric acid solutions using 4-(5-nonyl)pyridine

Iqbal¹,

Ejaz²

1975

Anal. Chem.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Extraction and separation studies of chromium(VI) from nitric acid solutions using 4-(5-nonyl)pyridine

Iqbal¹,

Ejaz²

1975

Anal. Chem.

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“…Several precipitation, solvent extraction and ion-exchange procedures are available in the literature (11)(12)(13) for the separation of Cr(III) from Cr(VI). A simple separation technique is the precipitation of Cr(III) as phosphate; Cr(VI) will remain in solution and can be filtered off.…”

Section: Theorymentioning

confidence: 99%

The chemical effects of nuclear transformation: A simple experiment for a radioisotope course

Rengan¹

1980

J. Chem. Educ.

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The Chemical Effects of Nuclear Transformation A simple experiment for a radioisotope course Szilard and Chalmers found (1) that when ethyl iodide was irradiated with neutrons a significant fraction of the radioactive 128I formed was present as inorganic iodine (as iodide ion or as elemental iodine). The breaking of carbon-iodine bond which results in the formation of inorganic iodine is due to recoil energy associated with the gamma ray emission occurring in the nuclear reaction. In general, a wide variety of chemical effects may accompany nuclear transformations. The

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“…Irradiation of enriched chromium-50 (natural abundance 4.4%) produces substantial amounts of chromium-51 if a high flux of thermal neutrons is available. Since economical reasons preclude the use of enriched material, the enhancement of specific activity of chromium-51 by a Szilard Chalmers process has been studied by a number of workers [3][4][5][6]. The yield and the specific activity, however, depend on the irradiation conditions.…”

Section: Introductionmentioning

confidence: 99%

Production of High Specific Activity Chromium-51 for Medical Uses

Iqbal

Ejaz

1975

Radiochimica Acta

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Sodium Chromate (Na 2 51 Cr0 4 ) suitable for medical diagnostic applications was prepared by irradiating potassium Chromate targets in the core of PARR at a thermal neutron flux of 2 χ 10 13 n cm -2 sec -1 . The recoil chromium atoms were separated by extraction of the bulk of Cr(VI) with 0.1 M 4-(5-nonjl) pyridine/benzene from dilute hydrochloric acid solutions and the effluent was purified in an anion exchange column. 98°/ 0 radiochemical purity and 25mCi 51 Cr/mgCr specific activity have been achieved. ZusammenfassungRadioaktives Natriumchromat (Na 2 61 Cr0 4 ) für medizinische Zwecke wurde hergestellt durch Bestrahlung von Kaliumchromat im PARR-Reaktor bei einer Flußdichte von 2 · ΙΟ 13 η cm -2 sec -1 . Die Rückstoßchromatome wurden von der Masse des Cr(VI) getrennt durch Extraktion aus verdünnter Salzsäure mit einer 0,1 M 4-(5-nonyl)pyridin/Benzol-Lösung. Es folgte noch eine Reinigung über einer Anionenaustauschersäule. Das Präparat war zu 98% radiochemisch rein und hatte eine spezifische Aktivität von 25 mCi 51 Cr/mgCr. RésuméLe radio-chromate de sodium (Na 2 51 Cr0 4 ) pour des buts médicaux a été préparé par irradiation du Chromate de potassium dans le coeur du réacteur PARR à une densité de flux thermale de 2 · 10 18 η cm -2 sec -1 . Les atomes 51 Cr de recul sont séparés de la masse du Cr(VI) par extraction d'une solution chlorhydrique avec une solution benzénique du 4-(5-nonyl)pyridine 0,1 molaire, suivie d'une purification sur une colonne d'un échangeur d'anions. Une pureté radiochimique de 98% et une activité spécifique de 25 mCi 51 Cr/mgCr ont été obtenues.

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Preparation of sodium chromate-51Cr and chromic chloride-51Cr for medical applications

Cited by 9 publications

References 8 publications

Extraction and separation studies of chromium(VI) from nitric acid solutions using 4-(5-nonyl)pyridine

Extraction and separation studies of chromium(VI) from nitric acid solutions using 4-(5-nonyl)pyridine

The chemical effects of nuclear transformation: A simple experiment for a radioisotope course

Production of High Specific Activity Chromium-51 for Medical Uses

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