Preparation of silk fibroin/hyaluronic acid hydrogels with enhanced mechanical performance by a combination of physical and enzymatic crosslinking

Qu, Xiaohang; Yan, Ling; Liu, Shuang; Tan, Yunfei; Xiao, Jiadong; Chen, Yuan; Chen, Ke; Xiao, Wenqian; Li, Bo; Liao, Xiaoling

doi:10.1080/09205063.2021.1932070

Cited by 27 publications

(6 citation statements)

References 45 publications

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“…In particular, by improving the SF structure by combining physical and enzymatic crosslinking strategies, an SF matrix composite hydrogel with enhanced strength and elasticity was obtained. This development also improves the shortcomings of traditional SF hydrogels with uneven structures and poor mechanical properties [84].…”

Section: Application In Regenerative Medicinementioning

confidence: 91%

Silkworm Cocoon: Dual Functions as a Traditional Chinese Medicine and the Raw Material of Promising Biocompatible Carriers

Tian,

Zhao,

Huang

et al. 2024

Pharmaceuticals

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The silkworm cocoon (SC), both as a traditional Chinese medicine and as the raw material for biocompatible carriers, has been extensively used in the medical and biomedical fields. This review elaborates on the multiple functions of SC, with an in-depth analysis of its chemical composition, biological activities, as well as its applications in modern medicine. The primary chemical components of SC include silk fibroin (SF), silk sericin (SS), and other flavonoid-like bioactive compounds demonstrating various biological effects. These include hypoglycemic, cardioprotective, hypolipidemic, anti-inflammatory, antioxidant, and antimicrobial actions, which highlight its potential therapeutic benefits. Furthermore, the review explores the applications of silk-derived materials in drug delivery systems, tissue engineering, regenerative medicine, and in vitro diagnostics. It also highlights the progression of SC from laboratory research to clinical trials, emphasizing the safety and efficacy of SC-based materials across multiple medical domains. Moreover, we discuss the market products developed from silk proteins, illustrating the transition from traditional uses to contemporary medical applications. This review provides support in understanding the current research status of SC and the further development and application of its derived products.

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Section: Application In Regenerative Medicinementioning

confidence: 91%

Silkworm Cocoon: Dual Functions as a Traditional Chinese Medicine and the Raw Material of Promising Biocompatible Carriers

Tian,

Zhao,

Huang

et al. 2024

Pharmaceuticals

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“…The swelling degree was determined by weighting composite hydrogel after a certain amount of time [ 28 , 29 ]. Hydrogels were taken out of the water after 1; 2; 3; 4; 5; 6; 24 h, and the excess water on the surface was dried on a wet paper tissue.…”

Section: Methodsmentioning

confidence: 99%

Enzymatically Crosslinked In Situ Synthesized Silk/Gelatin/Calcium Phosphate Hydrogels for Drug Delivery

2021

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Our research focuses on combining the valuable properties of silk fibroin (SF) and calcium phosphate (CaP). SF is a natural protein with an easily modifiable structure; CaP is a mineral found in the human body. Most of the new age biocomposites lack interaction between organic/inorganic phase, thus SF/CaP composite could not only mimic the natural bone, but could also be used to make drug delivery systems as well, which can ensure both healing and regeneration. CaP was synthesized in situ in SF at different pH values, and then crosslinked with gelatin (G), horseradish peroxide (HRP), and hydrogen peroxide (H2O2). In addition, dexamethasone phosphate (DEX) was incorporated in the hydrogel and drug delivery kinetics was studied. Hydrogel made at pH 10.0 was found to have the highest gel fraction 110.24%, swelling degree 956.32%, and sustained drug delivery for 72 h. The highest cell viability was observed for the hydrogel, which contained brushite (pH 6)—512.43%.

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“…Optical losses of SF exhibit as low as 0.25 dB/cm at 846 nm and 0.25 at 1549 nm, suggesting a strong potential for waveguiding mediums [ 74 ]. Through the different extraction methods of SF such as physically [ 75 ], chemically [ 76 ], enzymatic [ 77 ] or a combination of methods [ 78 ], waveguiding SF hydrogels were developed over the years.…”

Section: Optical Hydrogelsmentioning

confidence: 99%

Hydrogel for light delivery in biomedical applications

Yew,

Chee,

Lin

et al. 2024

Bioactive Materials

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Preparation of silk fibroin/hyaluronic acid hydrogels with enhanced mechanical performance by a combination of physical and enzymatic crosslinking

Cited by 27 publications

References 45 publications

Silkworm Cocoon: Dual Functions as a Traditional Chinese Medicine and the Raw Material of Promising Biocompatible Carriers

Silkworm Cocoon: Dual Functions as a Traditional Chinese Medicine and the Raw Material of Promising Biocompatible Carriers

Enzymatically Crosslinked In Situ Synthesized Silk/Gelatin/Calcium Phosphate Hydrogels for Drug Delivery

Hydrogel for light delivery in biomedical applications

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