Preparation of porous hydrophilic monoliths: Effect of the polymerization conditions on the porous properties of poly (acrylamide‐co‐N,N′‐methylenebisacrylamide) monolithic rods

Abstract

Molded macroporous monoliths with pores sizes up to 1000 nm have been prepared by copolymerization of the hydrophilic monomers, acrylamide, and N,Nmethylenebisacrylamide, in the presence of a porogenic diluent. A combination of dimethylsulfoxide and 2-heptanol was selected from a broad spectrum of solvents and water soluble polymers to achieve the optimum composition of the porogenic mixture. In addition to the composition of the porogen the porous properties of the monolithic rods can also be optimized through changes in the percentage of both N,N-methylenebisacrylamide (crosslinking monomer) and azobisisobutyronitrile (free radical initiator) used for the polymerization. The hydrophilic monoliths may be used in the separation of biological polymers, solid-phase extraction, or for immobilization of proteins.

Morphology Variation of Porous Polymer Gels by Polymerization in Lyotropic Surfactant Phases

“…This agreement also proves that the spheres are not porous by themselves (beside of the natural microporosity of all polymers, the so-called "solvent-pores"). It should also be noted that the "cauliflower-morphology" has already been observed for a number of other highly cross-linked acrylamide gels; see for instance ref 21.…”

Macroporous Monolithic Polymers: Preparation and Applications

“…A large number of nuclei compete for the remaining monomers, leading a higher number of small globules that aggregate with small pores. As concluded previously [ 6 ], the thermodynamic conditions that induce phase separation during polymerization depend on the composition of the polymerization mixture containing monomers and the porogen.…”

Development of new polar monolithic coatings for stir bar sorptive extraction

“…Thus, the polymerization temperature is an important parameter that influences the polymerization kinetics but that also controls the porous properties. At higher temperatures, the polymerization reaction is faster and a larger number of growing nuclei are formed; as a consequence, the surface area increases . Moreover, in a previous study it was observed that the higher the polymerization temperature, the softer the monolithic coating that was obtained.…”