Preparation of polyclonal antibodies to diminazene and its detection in animal blood plasma

Староверов, С. А.; Василенко, О. А.; Габалов, К. П.; Pristensky, Dmitry V.; Yermilov, D.N.; Aksinenko, N. M.; Shchyogolev, S. Yu.; Дыкман, Л. А.

doi:10.1016/j.intimp.2008.05.014

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…This suggestion was supported in papers devoted to the raising of antibodies to some peptides, [145][146][147][148][149] amino acids, [150][151][152][153] phenyl-b-D-thioglucoronide, 154 diminazene. 155 The antibodies obtained in this way possessed high specicities to the antigens under study and higher (as Pow and Crook 144 put it, "extremely high") titersfrom 1 : 250 000 to 1 : 1 000 000, as compared with the antibodies produced routinely. At present, the Australian-based company ImmunoSolution offers antibodies, obtained according to ref.…”

Section: Production Of Antibodies By Using Gold Nanoparticlesmentioning

confidence: 86%

Immunological Properties of Gold Nanoparticles

Дыкман¹,

Khlebtsov²

2017

Gold Nanoparticles in Biomedical Applications

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In the past decade, gold nanoparticles have attracted strong interest from the nanobiotechnological community owing to the significant progress made in robust and easy-to-make synthesis technologies, in surface functionalization, and in promising biomedical applications. These include bioimaging, gene diagnostics, analytical sensing, photothermal treatment of tumors, and targeted delivery of various biomolecular and chemical cargos. For the last-named application, gold nanoparticles should be properly fabricated to deliver the cargo into the targeted cells through effective endocytosis. In this review, we discuss recent progress in understanding the selective penetration of gold nanoparticles into immune cells. The interaction of gold nanoparticles with immune cell receptors is discussed. As distinct from other published reviews, we present a summary of the immunological properties of gold nanoparticles. This review also summarizes what is known about the application of gold nanoparticles as an antigen carrier and adjuvant in immunization for the preparation of antibodies in vivo. For each of the above topics, the basic principles, recent advances, and current challenges are discussed. Thus, this review presents a detailed analysis of data on interaction of gold nanoparticles with immune cells.Emphasis is placed on the systematization of data over production of antibodies by using gold nanoparticles and adjuvant properties of gold nanoparticles. Specifically, we start our discussion with current data on interaction of various gold nanoparticles with immune cells. The next section describes existing technologies to improve production of antibodies in vivo by using gold nanoparticles conjugated with specific ligands. Finally, we describe what is known about adjuvant properties of bare gold or functionalized nanoparticles. In the Conclusion section, we present a short summary of reported data and some challenges and perspectives.

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Section: Production Of Antibodies By Using Gold Nanoparticlesmentioning

confidence: 86%

Immunological Properties of Gold Nanoparticles

Дыкман¹,

Khlebtsov²

2017

Gold Nanoparticles in Biomedical Applications

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show abstract

“…This suggestion was supported in articles devoted to the raising of antibodies to some peptides, [467][468][469][470][471] amino acids, [472][473][474][475] phenyl-b-D-thioglucoronide, 476 and diminazene. 477 The antibodies obtained in this way possessed high specificities to the antigens under study and higher (as Pow and Crook 466 put it, ''extremely high'') titers-from 1 : 250 000 to 1 : 1 000 000, as compared with the antibodies produced routinely.…”

Section: Production Of Antibodies By Using Gnpsmentioning

confidence: 88%

Gold nanoparticles in biomedical applications: recent advances and perspectives

2012

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Gold nanoparticles (GNPs) with controlled geometrical, optical, and surface chemical properties are the subject of intensive studies and applications in biology and medicine. To date, the ever increasing diversity of published examples has included genomics and biosensorics, immunoassays and clinical chemistry, photothermolysis of cancer cells and tumors, targeted delivery of drugs and antigens, and optical bioimaging of cells and tissues with state-of-the-art nanophotonic detection systems. This critical review is focused on the application of GNP conjugates to biomedical diagnostics and analytics, photothermal and photodynamic therapies, and delivery of target molecules. Distinct from other published reviews, we present a summary of the immunological properties of GNPs. For each of the above topics, the basic principles, recent advances, and current challenges are discussed (508 references).

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“…This suggestion was supported in papers devoted to the raising of antibodies to some peptides, 145–149 amino acids, 150–153 phenyl-β- d -thioglucoronide, 154 diminazene. 155 The antibodies obtained in this way possessed high specificities to the antigens under study and higher (as Pow and Crook 144 put it, “extremely high”) titers – from 1 : 250 000 to 1 : 1 000 000, as compared with the antibodies produced routinely. At present, the Australian-based company ImmunoSolution offers antibodies, obtained according to ref.…”

Section: Production Of Antibodies By Using Gold Nanoparticlesmentioning

confidence: 92%

“…In 1986, Japanese researchers 103 first reported success in generating antibodies against glutamate by using colloidal gold particles as a carrier. Subsequently, a number of papers were published whose authors applied and further developed this technique to obtain antibodies to the following haptens and complete antigens: amino acids; 104 , 105 platelet-activating factor; 106 , 107 quinolinic acid; 108 biotin; 109 recombinant peptides; 110 , 111 lysophosphatide acid; 112 endostatin; 113 the capsid peptide of hepatitis C, 114 influenza, 115 foot-and-mouth disease, 116 , 117 and dengue 118 viruses; α-amidated peptides; 119 actin; 120 antibiotics; 121 ivermectin; 122 , 123 azobenzene; 124 Aβ-peptide; 125 clenbuterol; 126 α-methylacyl-CoA racemase; 127 Yersinia , 128 , 129 Listeria monocytogenes , 130 and Escherichia coli 131 surface antigens; Neisseria meningitides , 132 Streptococcus pneumoniae , 133 and Burkholderia mallei 134 , 135 carbohydrate antigens; Pseudomonas aeruginosa flagellin; 136 the transmissible gastroenteritis virus; 29 tuberculin; 137 , 138 the peptides of the malaria plasmodium surface proteins; 139 , 140 opisthorchiasis excretory–secretory antigen; 141 tetanus toxoid. 142 In all these studies, the haptens or complete antigens were directly conjugated to colloidal gold particles, mixed with complete Freund's adjuvant or alum, and used for animal immunization.…”

Section: Production Of Antibodies By Using Gold Nanoparticlesmentioning

confidence: 99%