Preparation of nanostructured silicon surface for mass spectrometry analysis by an all-wet fabrication process using electroless metal deposition and metal assisted etching

Tsao, Chia Wen; Yang, Zhi Jie; Chung, Cheng Wei

doi:10.1016/j.ijms.2012.05.007

Cited by 7 publications

(8 citation statements)

References 20 publications

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“…The corona discharge was seen when the custom PSI apparatus was too close to the inlet cone. Previous researchers have described an electron transfer reaction by corona discharge that neutralizes ions in some methods (Zhang, Cooks, & Ouyang, 2012;Li, Wang, Ouyang, & Cooks, 2011;Tsao, 2012). The corona discharge is a process by which a current flow from an electrode with a high-applied voltage.…”

Section: Importance Of the Corona Dischargementioning

confidence: 99%

“…It is possible that the difference in retention is a result of the size of pores in the paper since different papers had different capacity for ion production. Silicon nanoparticles have been used as a proton source on the surface for laser desorption ionization, matrix assisted laser desorption/ionization (MALDI), and secondary ion mass spectrometry (Liu, & He, 2008;Tsao, Yang, Chung, 2012;Gulin, Mochalova, Denisov, & Nadtochenko, 2014). Protons are generated when the SiO2 nanoparticles are hydrolyzed in the presence of water or organic solvent to form silicic acid Si (OH)4 (Liu et al, 2008;Gulin et al, 2014).…”

Section: Porosity Of Papermentioning

confidence: 99%

“…Protons are generated when the SiO2 nanoparticles are hydrolyzed in the presence of water or organic solvent to form silicic acid Si (OH)4 (Liu et al, 2008;Gulin et al, 2014). Recently, it was investigated Si nanoparticles on solid substrates as a mechanism for improved ionization but this approach has not been tried with PSI (Tsao et al, 2012). Silica nanoparticles formed an association with the cellulose in the paper that included both filling pores and adhering to the fibers and appear to be evenly spread across the surface of the paper.…”

Section: Porosity Of Papermentioning

confidence: 99%

“…Silica nanoparticles formed an association with the cellulose in the paper that included both filling pores and adhering to the fibers and appear to be evenly spread across the surface of the paper. This interaction between silica nanoparticles and cellulose molecules may include hydrogen bonding to the surface oxygen (Tsao et al, 2012). Analysis of standards indicated that the ionization efficiency was increased but the mechanism was not fully elucidated.…”

Section: Porosity Of Papermentioning

confidence: 99%

“…The plot show peak responses with coated paper higher than standard paper It was indicated that Si/cellulose interaction (hybrid) is an important factor that affects the silica nanoparticles film formation on the substrate. Poor interaction leads to variation in the ionization efficiency (Tsao et al, 2012). In order to produce an efficient Si/cellulose hybrid on the paper, the nanoparticles must be strongly adsorbed on the paper whilst avoiding damage of the paper.…”

Section: Porosity Of Papermentioning

confidence: 99%

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The Chemistry of Paper in Paper Spray Ionization Mass Spectrometry

Alsaggaf¹

2019

IJC

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There are many rapidly evolving technologies that use simple papers as a surface for chemical reactions and detection of molecules. One example of this application is the use of paper as a surface for ionization and introduction of compounds into mass spectrometry. The current work was designed to investigate mechanisms of interaction between the paper and analytes using mass spectrometry as the detection instrument. Standard compounds with different sizes were used in this study. Factors investigated include the effects of the paper geometry (5 mm) and position (tp=90º) were found to be optimal. The role of atmospheric water and the effects of paper porosity were affected the signals of the tested compounds. Investigations of the interaction of standard solutions with the paper surface indicated that atmospheric water is required for ionization. Up to three water molecules were detected in association with the analytes indicating that the presence of some water is required. In addition, this study showed the potential of silicon dioxide nanoparticles for eluting the standards compound from the paper surface. The impact of trace elements in the commercial papers and the interactions between the paper cellulose with different classes of analytes was investigated.

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Section: Importance Of the Corona Dischargementioning

confidence: 99%

Section: Porosity Of Papermentioning

confidence: 99%

Section: Porosity Of Papermentioning

confidence: 99%

Section: Porosity Of Papermentioning

confidence: 99%

Section: Porosity Of Papermentioning

confidence: 99%

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The Chemistry of Paper in Paper Spray Ionization Mass Spectrometry

Alsaggaf¹

2019

IJC

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Surface changes of biopolymers PHB and PLLA induced by Ar+ plasma treatment and wet etching

Kasálková

Slepička

Sajdl

et al. 2014

Nuclear Instruments and Methods in Physics Research Section B:

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Tip-Enhanced Photoinduced Electron Transfer and Ionization on Vertical Silicon Nanowires

Chen

Wang

et al. 2018

ACS Appl. Mater. Interfaces

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Nanostructured semiconductors are one of the most potent candidates for matrix-free laser desorption/ionization mass spectrometric (LDI-MS) analysis of low-molecular-weight molecules. Herein, the enhanced photoinduced electron transfer and LDI on the tip of a vertical silicon nanowire (SiNW) array were investigated. Theoretical simulation and LDI detection of indigo and isatin molecules in negative ion mode revealed that the electric field can be enhanced on the tip end of SiNWs, thereby promoting the energy and electron transfer to the analytes adsorbed on the tip of SiNWs. On the basis of this finding, a tip-contact sampling method coupled with LDI-MS detection was established. In this strategy, the tip of SiNWs can be regarded as microextraction heads for the sampling of molecules when they come in contact with analytes. Impression of skin, tissue, and pericarp on the vertical SiNW array can effectively transfer endogenous metabolites or exogenous substances onto the tip. Upon laser irradiation, the adsorbed molecules on the SiNW tip can be efficiently ionized and detected in negative ion mode because of the tip-enhanced electron transfer and LDI effect. We believe this work may significantly expand the application of LDI-MS in various fields.

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Preparation of nanostructured silicon surface for mass spectrometry analysis by an all-wet fabrication process using electroless metal deposition and metal assisted etching

Cited by 7 publications

References 20 publications

The Chemistry of Paper in Paper Spray Ionization Mass Spectrometry

The Chemistry of Paper in Paper Spray Ionization Mass Spectrometry

Surface changes of biopolymers PHB and PLLA induced by Ar+ plasma treatment and wet etching

Tip-Enhanced Photoinduced Electron Transfer and Ionization on Vertical Silicon Nanowires

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