Preparation of glycerol monostearate from glycerol carbonate and stearic acid

Li, Han; Wang, Tao

doi:10.1039/c6ra02912d

Cited by 28 publications

(17 citation statements)

References 19 publications

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“…Figure 3a shows the results of the FT-IR analysis for ceftriaxone sodium, Glycerol Monostearate, and nano-carriers containing ceftriaxone sodium. The FT-IR analysis of ceftriaxone sodium exhibits a band at 3444.63 cm − 1 , which can be attributed [26]. As shown in Fig.…”

Section: Characterization Of Optimized Structurementioning

confidence: 87%

Enhanced bactericidal effect of ceftriaxone drug encapsulated in nanostructured lipid carrier against gram-negative Escherichia coli bacteria: drug formulation, optimization, and cell culture study

Ebrahimi

Farhadian

Karimi

et al. 2020

Antimicrob Resist Infect Control

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Background: Ceftriaxone is one of the most common types of antibiotics used to treat most deadly bacterial infections. One way to alleviate the side effects of medication is to reduce drug consumption by changing the ordinary drug forms into nanostructured forms. In this study, a nanostructured lipid carrier (NLC) containing hydrophilic ceftriaxone sodium drug is developed, and its effect on eliminating gram-negative bacteria Escherichia coli death is investigated.Methods: Double emulsion solvent evaporation method is applied to prepare NLC. Mathematical modeling based on the solubility study is performed to select the best materials for NLC preparation. Haftyzer-Van Krevelen and Hoy's models are employed for this purpose. Drug release from optimized NLC is examined under in vitro environment. Then, the efficacy of the optimized sample on eliminating gram-negative bacteria Escherichia coli is investigated. Results: Mathematical modeling reveals that both methods are capable of predicting drug encapsulation efficiency trends by chaining solid and liquid lipids. However, Haftyzer-Van Krevelen's method can precisely predict the particle size trend by changing the surfactant types in water and oily phases of emulsions. The optimal sample has a mean particle size of 86 nm and drug entrapment efficiency of 83%. Also, a controlled drug release in prepared nanostructures over time is observed under in-vitro media. The results regarding the effectiveness of optimized NLC in killing Escherichia coli bacteria suggests that by cutting drug dosage of the nanostructured form in half, an effect comparable to that of free drug can be observed at longer times. Conclusion: Results confirm that NLC structure is an appropriate alternative for the delivery of ceftriaxone drug with a controlled release behavior.

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Section: Characterization Of Optimized Structurementioning

confidence: 87%

Enhanced bactericidal effect of ceftriaxone drug encapsulated in nanostructured lipid carrier against gram-negative Escherichia coli bacteria: drug formulation, optimization, and cell culture study

Ebrahimi

Farhadian

Karimi

et al. 2020

Antimicrob Resist Infect Control

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“…The main peaks related to the GMS structure were observed at 3314 cm À1 (O-H), 2916 cm À1 and 2849 cm À1 (C-H), 1730 cm À1 (C]O), 1180 cm À1 and 1047 cm À1 (C-O). 45 The principle peaks of melatonin were observed at 3303 cm À1 (N-H), 1629 cm À1 (C]O), 1555 cm À1 (C-O) and 1212 cm À1 (C-N). 46 The NLC spectrum is comparable to that of GMS, which could be due to high lipid content compared to the amount of drug.…”

Section: Particle Size and Morphology Tem (mentioning

confidence: 96%

Enhanced delivery of melatonin loaded nanostructured lipid carriers duringin vitrofertilization: NLC formulation, optimization and IVF efficacy

et al. 2020

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“…Repeated column chromatography for the n-BuOH Fr of M. verticillata aerial parts led to the isolation of four glycerides (1-4), which were identified as (2S)-1-O-palmitoyl glyceride [24], (2S)-1-O-stearoyl glyceride [25], (2S)-1-Olinolenoyl glyceride [26], and (2S)-1,2-di-O-linoleoyl glyceride [27], respectively, based on NMR, IR, FAB-MS, GC-MS, and FAB-MS analyses in addition to comparison of the data with those in literatures (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Glycerides isolated from the aerial parts of Malva verticillata cause immunomodulation effects via splenocyte function and NK anti-tumor activity

Castañeda

Joo

et al. 2018

Food Sci Biotechnol

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A preliminary study revealed that a 10 µg/mL -BuOH fraction of aerial parts significantly enhanced splenocyte proliferation and induced significant enhancement of natural-killer (NK) cell activity against tumor cells (YAC-1). This study was initiated to identify the principal components that exhibited these activities, and four glycerides were isolated through repeated SiO and ODS column chromatography. Structures of compounds - were determined to be (2)-1--palmitoyl glyceride, (2)-1--stearoyl glyceride, (2)-1--linolenoyl glyceride, and (2)-1,2-di--linoleoyl glyceride, respectively. Compounds - showed potential immune-enhancing activity in murine splenocyte and natural-killer (NK) cells at 10 µM. In contrast, compound showed weak activity, indicating the monoacyl glycerides (-) are more effective than diacyl glyceride (). Also, the longer the carbon number of the fatty acid in monoacyl glyceride, the better the activity, and the monoacyl glyceride including an unsaturated fatty acid () is more effective than the glycerides including the saturated fatty acids (-).

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Preparation of glycerol monostearate from glycerol carbonate and stearic acid

Abstract: A new two-step procedure prepares glycerol monostearate from glycerol carbonate and stearic acid.

Cited by 28 publications

References 19 publications

Enhanced bactericidal effect of ceftriaxone drug encapsulated in nanostructured lipid carrier against gram-negative Escherichia coli bacteria: drug formulation, optimization, and cell culture study

Enhanced bactericidal effect of ceftriaxone drug encapsulated in nanostructured lipid carrier against gram-negative Escherichia coli bacteria: drug formulation, optimization, and cell culture study

Enhanced delivery of melatonin loaded nanostructured lipid carriers duringin vitrofertilization: NLC formulation, optimization and IVF efficacy

Glycerides isolated from the aerial parts of Malva verticillata cause immunomodulation effects via splenocyte function and NK anti-tumor activity

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