Preparation of “dummy” <scp>l‐</scp>phenylalanine molecularly imprinted microspheres by using ionic liquid as a template and functional monomer

Ji, Li; Hu, Xiaoling; Guan, Ping; Song, Dongmen; Qian, Liwei; Du, Chunbao; Song, Renyuan; Wang, Chaoli

doi:10.1002/jssc.201500539

Cited by 20 publications

(14 citation statements)

References 35 publications

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“…For example, as shown in Figure D, Li et al have prepared a novel l ‐Phe MIPs using 1‐butyl‐3‐vinylimidazolium α‐aminohydrocinnamic acid salt ([Vbim][Phe]) as dummy template. The binding experiment showed that the obtained l ‐Phe MIPs possessed high bind capacity of 280.18 µmol g −1 and imprinting factor of 3.17, which was attributed to the formed ion‐pairs between imidazolium and l ‐phenylalanine in the dummy template …”

Section: Biological Molecular Imprinting With Different Scalementioning

confidence: 99%

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Molecularly Imprinted Materials for Selective Biological Recognition

Zhang

et al. 2019

Macromol. Rapid Commun.

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Molecular imprinting is an approach of generating imprinting cavities in polymer structures that are compatible with the target molecules. The cavities have memory for shape and chemical recognition, similar to the recognition mechanism of antigen–antibody in organisms. Their structures are also called biomimetic receptors or synthetic receptors. Owing to the excellent selectivity and unique structural predictability of molecularly imprinted materials (MIMs), practical MIMs have become a rapidly evolving research area providing key factors for understanding separation, recognition, and regenerative properties toward biological small molecules to biomacromolecules, even cell and microorganism. In this review, the characteristics, morphologies, and applicability of currently popular carrier materials for molecular imprinting, especially the fundamental role of hydrogels, porous materials, hierarchical nanoparticles, and 2D materials in the separation and recognition of biological templates are discussed. Moreover, through a series of case studies, emphasis is given on introducing imprinting strategies for biological templates with different molecular scales. In particular, the differences and connections between small molecular imprinting (bulk imprinting, “dummy” template imprinting, etc.), large molecular imprinting (surface imprinting, interfacial imprinting, etc.), and cell imprinting strategies are demonstrated in detail. Finally, future research directions are provided.

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Section: Biological Molecular Imprinting With Different Scalementioning

confidence: 99%

“…Copyright 2016, Elsevier; D) a new IL‐based MIP was prepared by ion‐pair dummy template imprinting, which confined the charged monomer in the imprinting cavities. Reproduced with permission . Copyright 2015, Royal Society of Chemistry.…”

Section: Biological Molecular Imprinting With Different Scalementioning

confidence: 99%

Molecularly Imprinted Materials for Selective Biological Recognition

Zhang

et al. 2019

Macromol. Rapid Commun.

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“…When cells reach their proliferative limit, they start displaying signs of ageing such as large flat morphology, increased granularity, and a vacuole-rich cytoplasm. They also show increased intrinsic fluorescence which is caused by the accumulation of oxidatively damaged proteins and lipids and senescence-associated ß-galactosidase activity [38]. This growth arrested metabolically active state is known as senescence.…”

Section: Low Glucose Availability Instigate Senescencementioning

confidence: 99%

Low Sugar Diet: A New Tool in War Against Tumorigenesis

Agarwal¹,

Maurya²

2018

Proc. Nat. Res. Soc.

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Cancer is a metabolic disease. Their typical characteristic is high consumption of glucose as these cells mostly have defective mitochondria. They primarily derive energy through aerobic glycolysis even in presence of abundant oxygen. Cancer cells thus are heavily dependent on ample and continuous availability of glucose for growth, proliferation and invasion. These cells adopt various strategies to satisfy their high demand for sugar which includes modification in signalling pathways and abnormally high expression of glucose transporters. Glucose uptake is favoured by alteration in PI3K-Akt-mTOR pathway. High glucose condition creates conducive environment for cancer cells to flourish. The H+ ion secreted as by-product of glycolysis helps in invasion and metastasis. Other by products of glycolysis which includes ATP, NADP and NADPH also aids in growth of cancer cells. Glucose restriction puts break on speedy multiplying tumor cells as unlike normal cells of the body they are unable to metabolize any other source of fuel. Lower glucose level induces changes in level of cleaved caspase 3, Bcl-2, p53 and p21 which prompts senescence and apoptosis in rapidly proliferating tumor cells. Various strategies can be employed to cut down glucose accessibility to cancer cells such as inhibition of glucose transporters, adoption of keto diet. Combining glucose restriction with either chemo or radiotherapy increases their effectiveness; lower CHO levels also provide protection to normal healthy cells of the body against toxic effect of anti-carcinogens. Carbohydrate restriction is a non-toxic, easily impeccable, economical and safe tactic which may be utilized as weapon in war against cancer.

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“…Previously , we have reported a strategy for the recognition of l‐ Phe by ion‐pair dummy template imprinting, which creates an imprinted polymer, using 1‐butyl‐3‐vinylimidazolium α‐aminohydrocinnamic acid salt as the template and functional monomer. The interactions between the functional monomer and template are improved by theoretical and chromatographic methods.…”

Section: Introductionmentioning

confidence: 99%

Preparation of l‐phenylalanine‐imprinted solid‐phase extraction sorbent by Pickering emulsion polymerization and the selective enrichment of l‐phenylalanine from human urine

Guan

et al. 2016

J of Separation Science

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A novel l-phenylalanine molecularly imprinted solid-phase extraction sorbent was synthesized by the combination of Pickering emulsion polymerization and ion-pair dummy template imprinting. Compared to other polymerization methods, the molecularly imprinted polymers thus prepared exhibit a high specific surface, large pore diameter, and appropriate particle size. The key parameters for solid-phase extraction were optimized, and the result indicated that the molecularly imprinted polymer thus prepared exhibits a good recovery of 98.9% for l-phenylalanine. Under the optimized conditions of the procedure, an analytical method for l-phenylalanine was well established. By comparing the performance of the molecularly imprinted polymer and a commercial reverse-phase silica gel, the obtained molecularly imprinted polymer as an solid-phase extraction sorbent is more suitable, exhibiting high precision (relative standard deviation 3.2%, n = 4) and a low limit of detection (60.0 ± 1.9 nmol·L(-1) ) for the isolation of l-phenylalanine. Based on these results, the combination of the Pickering emulsion polymerization and ion-pair dummy template imprinting is effective for preparing selective solid-phase extraction sorbents for the separation of amino acids and organic acids from complex biological samples.

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Preparation of “dummy” l‐phenylalanine molecularly imprinted microspheres by using ionic liquid as a template and functional monomer

Cited by 20 publications

References 35 publications

Molecularly Imprinted Materials for Selective Biological Recognition

Molecularly Imprinted Materials for Selective Biological Recognition

Low Sugar Diet: A New Tool in War Against Tumorigenesis

Preparation of l‐phenylalanine‐imprinted solid‐phase extraction sorbent by Pickering emulsion polymerization and the selective enrichment of l‐phenylalanine from human urine

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