Preparation of curcumin-loaded pluronic F127/chitosan nanoparticles for cancer therapy

Le, Thi Minh Phuc; Pham, Van Phuc; Dang, Thi Minh Lua; La, Thi Huyen; Le, Thi Hanh; Le, Quang Huan

doi:10.1088/2043-6262/4/2/025001

Cited by 16 publications

(7 citation statements)

References 24 publications

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“…The EE% of curcumin in CaANCs reached up to 95%. This value is higher or comparable to those reported for other curcumin-loaded nanoparticles: 80% to 82% in liposomes [63], less than 90% in mPEG-PLGA nanoparticles [64], 91% for curcumin-loaded PLGA nanospheres [65], 62% with curcumin-loaded pluronic F127/ chitosan nanoparticles [66], 94% for curcumin loaded PLGA nanoparticles [67]. An EE% of 52% was described in other alginate formulations [35] and 68% in alginate chitosan nanocapsules [14].…”

Section: Curcumin Encapsulation In Caancssupporting

confidence: 74%

Novel alginate-based nanocarriers as a strategy to include high concentrations of hydrophobic compounds in hydrogels for topical application

et al. 2015

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The cutaneous penetration of hydrophobic active molecules is of foremost concern in the dermatology and cosmetic formulation fields. The poor solubility in water of those molecules limits their use in hydrophilic forms such as gels, which are favored by patients with chronic skin disease. The aim of this work is to design a novel nanocarrier of hydrophobic active molecules and to determine its potential as an ingredient of a topical form. The nanocarrier consists of an oily core surrounded by a protective shell of alginate, a natural polysaccharide isolated from brown algae. These calcium alginate-based nanocarriers (CaANCs) were prepared at room temperature and without the use of organic solvent by an accelerated nanoemulsification-polymer crosslinking method. The size (hydrodynamic diameter ~200 nm) and surface charge (zeta potential ~ - 30 mV) of the CaANCs are both compatible with their application on skin. CaANCs loaded with a fluorescent label were stable in model hydrophilic galenic forms under different storage conditions. Curcumin was encapsulated in CaANCs with an efficiency of ~95%, fully retaining its antioxidant activity. The application of the curcumin-loaded CaANCs on excised human skin led to a significant accumulation of the active molecules in the upper layers of the skin, asserting the potential of these nanocarriers in active pharmaceutical and cosmetic ingredients topical delivery.

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Section: Curcumin Encapsulation In Caancssupporting

confidence: 74%

Novel alginate-based nanocarriers as a strategy to include high concentrations of hydrophobic compounds in hydrogels for topical application

et al. 2015

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“…PF is highly soluble in water and dispersible across a broad spectrum of solvents and temperatures, enabling its utilization across a diverse array of applications [27]. However, using polymeric micelles with the sole co-polymer as prolonged drug carriers is not feasible in practice due to the tendency of particle aggregation and physical deterioration under different concentrations and temperatures [28]. The outer shell of polymeric micelles performs a pivotal function in enhancing the bioactivity and characteristics of the particles.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Primary Bioactivity Evaluation of Novel Water-Soluble Curcumin-Loaded Polymeric Micelles Fabricated with Chitooligosaccharides and Pluronic F-68

Ingrungruengluet,

Wang,

et al. 2023

Pharmaceutics

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Curcumin (CU) is a bioactive compound extracted from turmeric and has various advantages. However, the benefit of CU is limited by its low water solubility (11 ng/mL). This research aimed to fabricate a water-soluble CU nano-formulation with chitooligosaccharides (COS) and pluronic F-68 (PF) utilizing the polymeric micelle method. The optimized curcumin-loaded chitooligosaccharides/pluronic F-68 micelles (COSPFCU) exhibited high encapsulation efficiency and loading capacity (75.57 ± 2.35% and 10.32 ± 0.59%, respectively). The hydrodynamic diameter of lyophilized COSPFCU was 73.89 ± 11.69 nm with a polydispersity index below 0.3. The COSPFCU could be completely redispersed in water and showed high DPPH scavenging ability. Meanwhile, COSPFCU could significantly reduce the cytotoxicity of the RAW 264.7 cells compared to native CU. Furthermore, COSPFCU improved the inhibition of NO release activity at 72.83 ± 2.37% but 33.20 ± 3.41% for the CU, with a low cytotoxicity concentration in the RAW 264.7 cells.

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“…Several studies have shown that the stability of Pluronic® micelles can be significantly improved after being coated with a chitosan layer [58,59]. The use of chitosan provides numerous advantages due to its biodegradability, biocompatibility, ease of technical application, versatility and low toxicity.…”

Section: Chitosanmentioning

confidence: 99%

Combined Nanochemotherapy Using Doxorubicin and Curcumin as an Example

Kaniuk¹

2023

Biotechnol. acta

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The aim of the work was to review literature data on combined nanochemotherapy using the example of two drugs ̶doxorubicin and curcumin. Special attention was paid to the use of substances with synergistic properties in one nanoparticle, capable to penetrate into living cell. The method of combined chemotherapy of nanopreparations improves processing efficiency. The technique of using nanocontainers with synergistic drugs in combination with ligands reduces the side effects of chemotherapy drugs. Results. Literature data indicate that the use of nanopreparations contributes the rapid creation and use of synergistic combinations that were purposefully delivered to target cells, reducing dosage due to precise targeting. A promising direction of nanomedicine is the creation of multifunctional nanomaterials based on several active drugs having synergistic properties, with the simultaneous use of their enhancers and the strategy of active targeting. These structures enabled targeted and controlled penetration of medicinal compounds into the localization of pathological processes, reducing drugs toxicity for normal cells. Conclusions. Combined chemotherapy using polymers and nanoparticles with ligands, in which synergistic drugs are included, ensures to reduce side effects and doses of chemotherapy drugs, and helps to overcome multiple drug resistance as well.

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Preparation of curcumin-loaded pluronic F127/chitosan nanoparticles for cancer therapy

Cited by 16 publications

References 24 publications

Novel alginate-based nanocarriers as a strategy to include high concentrations of hydrophobic compounds in hydrogels for topical application

Novel alginate-based nanocarriers as a strategy to include high concentrations of hydrophobic compounds in hydrogels for topical application

Preparation and Primary Bioactivity Evaluation of Novel Water-Soluble Curcumin-Loaded Polymeric Micelles Fabricated with Chitooligosaccharides and Pluronic F-68

Combined Nanochemotherapy Using Doxorubicin and Curcumin as an Example

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