Preparation of biphasic hydroxyapatite/ β-tricalcium phosphate foam using the replication technique

Khallok, Hamza; Elouahli, Abdelaziz; Ojala, Satu; Keiski, Riitta L.; Kheribech, A.; Hatim, Z.

doi:10.1016/j.ceramint.2020.06.019

Cited by 16 publications

(8 citation statements)

References 40 publications

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“…The dried template is then heat-treated to decompose the organic sponges (pyrolysis). After removing the polymer template, ceramic or metal structures are baked at higher temperatures to seal the walls of the posts [32,33].…”

Section: Literature Reviewmentioning

confidence: 99%

Influence of Technological Manufacturing Conditions on the Porosity of Calcium-Phosphate Scaffolds

Chernobrovchenko¹,

Dyadyura²,

Balynskyi³

et al. 2021

JES

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The implantation of bone substitutes depends on the material’s osteoconductive potential and the structure’s porosity Porosity is a characteristic feature of most materials. The porosity of materials has a strong influence on some of their properties, both structural and functional. An essential requirement for bone scaffolds is porosity, which guides cells into their physical structure and supports vascularization. The macroporosity should be large enough and interdependent for bone ingrowth to occur throughout the entire volume of the implant. The pore size for cell colonization in bioceramics is approximately 100 μm. Pores larger than this value promote bone growth through the material. This pore size allows the flow of growth factors and cell adhesion and proliferation, allowing the formation of new bone and developing the capillary system associated with the ceramic implant. Porosity also affects the rate of resorption of ceramics: the larger the number of micropores, the higher the dissolution rate. The investigated properties were elastic moduli, ultimate strength, compressive strength, and average apparent density. The results obtained in this work are consistent with previous studies, proving the positive role of microporosity in osseointegration and bone formation.

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Section: Literature Reviewmentioning

confidence: 99%

Influence of Technological Manufacturing Conditions on the Porosity of Calcium-Phosphate Scaffolds

Chernobrovchenko¹,

Dyadyura²,

Balynskyi³

et al. 2021

JES

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“…However, although β-TCP is biocompatible, it shows a weak bioactivity [ 5 ]. Recently, it was reported that the chemical and biological properties of HAP and β-TCP may be improved by their association with metals [ 6 ], organic compounds [ 7 ] or by the substitution of foreign ions in their crystal structure as Na + [ 8 , 9 ], Mg 2+ [ 10 ], Sr 2+ /F − [ 11 ], SiO 4 4− [ 12 ] and Al 3+ [ 13 ]. Biological apatite is non-stoichiometric due to the presence of a different oligo-elements as Zn 2+ , Mg 2+ , Na + , CO 3 2−- [ 14 , 15 ], which play an important role in biological processes related to bone and connective tissue development [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Apatitic calcium phosphate/montmorillonite nano-biocomposite: in-situ synthesis, characterization and dissolution properties

Jamil

Elouahli

Abida

et al. 2022

Heliyon

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“…Their excellent physical and chemical properties can better control the balance between biological activity and biodegradability. [16][17][18] Recently, many researchers had attempted to synthesize HA/β-TCP composite by various synthetic processes, such as the blending of different calcium phosphates in solid-state reactions, [19] co-precipitation, [20] liquid mix techniques, [21] microwave, [22] and high-energy drying milling. [23] Among them, the co-precipitation technique is considered to be the simplest and most cost-effective method.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, HA/β‐TCP has unique advantages in the field of drug delivery. Their excellent physical and chemical properties can better control the balance between biological activity and biodegradability [16–18] …”

Section: Introductionmentioning

confidence: 99%

Effect of Morphology on the Drug Sustained‐Release Performance of HA/β‐TCP Composite

et al. 2022

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Hydroxyapatite/tricalcium phosphate (HA/β-TCP) has been widely studied as a drug carrier, but the drug loading and release rate of the composites with different morphology significantly vary. In this paper, needle-shaped, rod-shaped, and ordered porous HA/β-TCP composite was prepared by chemical co-precipitation method, and ibuprofen (IBU) was used as a drug model to study the sustained-release properties of IBU in vitro. The results showed that morphology of the HA/ β-TCP composite had a significant effect on the drug loading of IBU. The IBU loading of the ordered porous composite was as high as 101.3 mg/g, which was 2.2 times and 3.46 times higher than that of the rod-shaped and needle-shaped composite to IBU, respectively. The drug release test of IBU showed that the release rate of the ordered porous HA/β-TCP to IBU was slower than that of the rod-shaped and needle-shaped composite in the initial 10 h, and reached the drug release equilibrium after the subsequent 30 h. The cumulative release of the ordered porous HA/β-TCP composite to IBU reached 83.79 %, which was significantly smaller than that of the needle-shaped and the rod-shaped, showing better slow-release performance for IBU. The ordered porous HA/β-TCP composite have great application potential in quantitative drug delivery systems.

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Preparation of biphasic hydroxyapatite/ β-tricalcium phosphate foam using the replication technique

Cited by 16 publications

References 40 publications

Influence of Technological Manufacturing Conditions on the Porosity of Calcium-Phosphate Scaffolds

Influence of Technological Manufacturing Conditions on the Porosity of Calcium-Phosphate Scaffolds

Apatitic calcium phosphate/montmorillonite nano-biocomposite: in-situ synthesis, characterization and dissolution properties

Effect of Morphology on the Drug Sustained‐Release Performance of HA/β‐TCP Composite

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