PLoS ONE volume 9, issue 6, Pe98455 2014 DOI: 10.1371/journal.pone.0098455 View full text
Qingchao Tang, Yihui Wang, Rui Huang, Qi You, Guiyu Wang, Yinggang Chen, Zheng Jiang, Zheng Liu, Lei Yu, Shan Muhammad, Xishan Wang

Abstract: Background5-Fluorouracil (5-FU) is one of the most classic chemotherapy drugs. Nanoparticle drug delivery vehicles offer superiority over target effect enhancement and abatement of side effects. Little is known however as to the specific effect of nanoparticle on peritoneal dissemination of colon cancer. The aim of this study is to prepare one NPs (nanoparticles) loaded with 5-FU and investigate the characteristic of NPs and the role of it in peritoneal metastasis nodules formation of human colon cancer.Method…

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