Preparation of an electrochemical biosensor based on indium tin oxide and its performance in detecting antibiotic resistance genes

Wan, Chunli; Qu, Aoxuan; Deng, Liyan; Liu, Xiang; Wu, Changyong

doi:10.1016/j.microc.2022.107953

Cited by 7 publications

(4 citation statements)

References 29 publications

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“…Indium tin oxide (ITO) thin structures are n-type degenerated semiconductors with high optical transmittance in the visible and near-infrared ranges. Due to their relatively small sheet resistance (10 −4 -10 −3 Ω × cm) [1][2][3] and high transparency [4][5][6], thin films based on the ITO layer are widely used in optical electronics [7][8][9], biosensors [10][11][12] and electrochemistry [13][14][15]. The nanotechnology approach indeed provokes better basic Coatings 2024, 14, 178 2 of 16 features in the ITO.…”

Section: Introductionmentioning

confidence: 99%

Perspective Coatings Based on Structured Conducting ITO Thin Films for General Optoelectronic Applications

Toikka,

Ilin,

Kamanina

2024

Coatings

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In many electro-optical devices, the conductive layer is an important key functional element. Among others, unique indium tin oxide (ITO) contacts take priority. ITO structure is widely used as the optical transparent and electrically conductive material in general optoelectronics, biosensors and electrochemistry. ITO is one of the key elements in the liquid crystal (LC) displays, spatial light modulators (SLMs) and LC convertors. It should be mentioned that not only the morphology of this layer structure but also the surface features play an important role in the study of the physical parameters of the ITO. In order to switch the surface properties (roughness, average tilt angle and surface free energy) of the ITO via the laser-oriented deposition (LOD) method, carbon nanotubes (CNTs) were implanted. In the LOD technique, the CO2 laser (λ = 10.6 μm, P = 30 W) with the control electric grid was used. The switching of the deposition conditions was provided via the varying electrical strength of the control grid in the range of 100–600 V/cm. The diagnostics of the surfaces were performed using AFM analysis and wetting angle measurements. The components of the surface free energy (SFE) were calculated using the OWRK method. The main experimental results are as follows: the roughness increases with a rise in the electric field strength during the deposition of the CNTs; the carbon nanotubes provide a higher level of the dispersive component of SFE (25.0–31.4 mJ/m2 against 22.2 mJ/m2 in the case of pure ITO); the CNTs allow an increase in the wetting angle of the 5CB liquid crystal drops from 38.35° to 58.95°. Due to the possibility of the switching properties of the ITO/CNT surfaces, these modifications have potential interest in microfluidics applications and are useful for the liquid crystal’s electro-optics.

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Section: Introductionmentioning

confidence: 99%

Perspective Coatings Based on Structured Conducting ITO Thin Films for General Optoelectronic Applications

Toikka,

Ilin,

Kamanina

2024

Coatings

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“…However, its conductivity can be further enhanced by increasing the thickness of the ITO layer, and therefore, designing a highly sensitive fiber optic LMR sensor with ITO is possible, which makes it a favorable contender to be used in the present study. Recently, ITO was also used for the fabrication of an electrochemical biosensor for the detection of antibiotic resistance genes in a water environment, and the results demonstrated a strong correlation with the electrochemical signals [ 48 ]. Another electrochemical sensor was proposed for the detection of sulfamethoxazole using a composite of graphene oxide/graphene over an ITO substrate [ 49 ].…”

Section: Introductionmentioning

confidence: 99%

Design Considerations of an ITO-Coated U-Shaped Fiber Optic LMR Biosensor for the Detection of Antibiotic Ciprofloxacin

Vikas

Saccomandi

2023

Biosensors

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The extensive use of antibiotics has become a serious concern due to certain deficiencies in wastewater facilities, their resistance to removal, and their toxic effects on the natural environment. Therefore, substantial attention has been given to the detection of antibiotics because of their potential detriment to the ecosystem and human health. In the present study, a novel design of indium tin oxide (ITO) coated U-shaped fiber optic lossy mode resonance (LMR) biosensor is presented for the sensitive detection of the antibiotic ciprofloxacin (CIP). The performance of the designed U-shaped LMR sensor is characterized in terms of its sensitivity, full width at half maximum (FWHM), the figure of merit (FOM), and the limit of detection (LOD). For the proposed U-shaped LMR sensing probe, the various crucial factors such as the thickness (d) of the ITO layer, sensing region length (L), and bending radius (R) are optimized. The thickness of the ITO layer is optimized in such a way that two LMR curves are observed in the transmission spectrum and, thereafter, the performance parameters are evaluated for each LMR. It is observed that the designed U-shaped LMR sensor with optimized parameters shows an approximately seven-fold enhancement in sensitivity compared to the straight-core fiber optic LMR sensor. The numerical results revealed that the designed U-shaped fiber optic LMR biosensor can provide a maximum sensitivity of 17,209.9 nm/RIU with the highest FOM of 91.42 RIU−1, and LOD of 6.3 × 10−5 RIU for the detection of CIP hydrochloride in the concentration range of 0.001 to 0.029 mol∙dm−3. Thus, it is believed that the designed LMR biosensor can practically explore its potential use in environmental monitoring and biomedical applications and hence, opens a new window of opportunity for the researchers working in the field of U-shaped fiber optic LMR biosensing.

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“…Numerous studies have improved biosensor performance by using nanomaterials such as multiwalled carbon nanotubes (MWCNTs), 11 zinc oxide nanoparticles, 11 gold nanoparticles, 12 carbon dots Fe 3 O 4 , 13 silica nanoparticles, 14 Au–Pt bimetallic nanoparticles/graphene oxide 15 and etc. as a sensing layer in DNA biosensors fabrication.…”

Section: Introductionmentioning

confidence: 99%

Strategies in the optimization of DNA hybridization conditions and its role in electrochemical detection of dengue virus (DENV) using response surface methodology (RSM)

et al. 2023

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Preparation of an electrochemical biosensor based on indium tin oxide and its performance in detecting antibiotic resistance genes

Cited by 7 publications

References 29 publications

Perspective Coatings Based on Structured Conducting ITO Thin Films for General Optoelectronic Applications

Perspective Coatings Based on Structured Conducting ITO Thin Films for General Optoelectronic Applications

Design Considerations of an ITO-Coated U-Shaped Fiber Optic LMR Biosensor for the Detection of Antibiotic Ciprofloxacin

Strategies in the optimization of DNA hybridization conditions and its role in electrochemical detection of dengue virus (DENV) using response surface methodology (RSM)

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