Preparation of Alum-borneol-PVP Drug-loaded Fibers by Electrospinning

Huang, Libing; Liu, Yueqi; Sang, Xinyu; Song, Jinghui; Hu, Ping; Liu, Yong

doi:10.1007/s40242-020-0225-9

Cited by 9 publications

(2 citation statements)

References 15 publications

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“…The biodegradable polymer poly(3-hydroxybutyrate- co -3-hydroxyvalerate) (PHBV), a semicrystalline copolymer synthesized by bacteria, − was exploited as an outer layer of nanodrug containers. Unlike the traditional monolithic nanodrug container, the novel nanodrug container uses the common drug carrier polyvinylpyrrolidone (PVP) as the core layer to load drugs. ,, As a model drug, the water-insoluble curcumin (Cur) needs sustained release to ensure appropriate drug concentration in a long period of time in the treatment. In this study, nanodrug containers with drug-sustained release were designed and characterized in detail.…”

Section: Introductionmentioning

confidence: 99%

Electrospun PVP-Core/PHBV-Shell Fibers to Eliminate Tailing Off for an Improved Sustained Release of Curcumin

Liu

Chen

et al. 2021

Mol. Pharmaceutics

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Tailing off release in the sustained release of water-insoluble curcumin (Cur) is a significant challenge in the drug delivery system. As a novel solution, core–shell nanodrug containers have aroused many interests due to their potential improvement in drug-sustained release. In this work, a biodegradable polymer, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), and hydrophilic polyvinylpyrrolidone (PVP) were exploited as drug delivery carriers by coaxial electrospinning, and the core–shell drug-loaded fibers exhibited improved sustained release of Cur. A cylindrical morphology and a clear core–shell structure were observed by scanning and transmission electron microscopies. The X-ray diffraction pattern and infrared spectroscopy revealed that Cur existed in amorphous form due to its good compatibility with PHBV and PVP. The in vitro drug release curves confirmed that the core–shell container manipulated Cur in a faster drug release process than that in the traditional PHBV monolithic container. The combination of the material and structure forms a novel nanodrug container with a better sustained release of water-insoluble Cur. This strategy is beneficial for exploiting more functional biomedical materials to improve the drug release behavior.

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Section: Introductionmentioning

confidence: 99%

Electrospun PVP-Core/PHBV-Shell Fibers to Eliminate Tailing Off for an Improved Sustained Release of Curcumin

Liu

Chen

et al. 2021

Mol. Pharmaceutics

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“…Electrospinning, a common strategy for preparing tissue engineering scaffolds, can produce continuous micro or nanofibers. A high specific surface area can greatly promote tissue regeneration when loaded with drugs or growth factors. , High porosity and large pore sizes allow cells to infiltrate and grow into the scaffolds, which has incomparable advantages in the regeneration of thicker tissues . Good mechanical strength and biocompatibility can provide favorable conditions for cell adhesion and growth .…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in Electrospun Nanofiber-Based Degenerated Intervertebral Disc Repair

Chen

et al. 2021

ACS Biomater. Sci. Eng.

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Annulus fibrosus fissure and fibrosis of nucleus pulposus are severe morphological characteristics of intervertebral disc degeneration. Currently, surgery or drugs are used to relieve pain in such cases. Tissue engineering is a new multidisciplinary strategy with great potential for use in joint replacement and organ regeneration. Based on the natural anatomy of intervertebral discs, intervertebral disc scaffolds are fabricated by exploiting the special arrangement of extracellular matrix fibers. Electrospun nanofibers possess clear advantages in repairing degenerated intervertebral discs. This article reviews and summarizes recently developed methods for improving and fabricating electrospun nanofiber annulus fibrosus scaffolds in terms of nanofiber alignment, material selection, loading additives, and the progress made in combining other advanced technologies with electrospun nanofibers. In addition, the improvement in mechanical properties and biocompatibility of nucleus pulposus scaffolds by electrospun nanofiber-reinforced hydrogels is discussed. Finally, complete intervertebral disc scaffolds can be fabricated using the disc-like angle-ply structure and other emerging fabrication methods. Taken together, electrospun nanofiber intervertebral disc scaffolds are promising for clinical applications.

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Electrospun high bioavailable rifampicin–isoniazid-polyvinylpyrrolidone fiber membranes

Liu

Chen

et al. 2021

Appl Nanosci

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Preparation of Alum-borneol-PVP Drug-loaded Fibers by Electrospinning

Cited by 9 publications

References 15 publications

Electrospun PVP-Core/PHBV-Shell Fibers to Eliminate Tailing Off for an Improved Sustained Release of Curcumin

Electrospun PVP-Core/PHBV-Shell Fibers to Eliminate Tailing Off for an Improved Sustained Release of Curcumin

Recent Progress in Electrospun Nanofiber-Based Degenerated Intervertebral Disc Repair

Electrospun high bioavailable rifampicin–isoniazid-polyvinylpyrrolidone fiber membranes

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