Preparation of a pH sensitive hydrogel based on dextran and polyhydrazide for release of 5-flurouracil, an anticancer drug

Jalalvandi, Esmat; Hanton, Lyall R.; Moratti, Stephen C.

doi:10.1016/j.jddst.2017.12.011

Cited by 20 publications

(16 citation statements)

References 30 publications

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“…Their results showed that the loading capacity of the drug was 75.3% and the drug release mechanism followed Fickian diffusion. In another work, Jalalvandi et al designed dextran/polyhydrazide‐based hydrogel network samples to investigate their capability for 5‐FU release. The obtained outcomes revealed that these samples enabled to prolong the drug release for almost 2 days.…”

Section: Introductionmentioning

confidence: 99%

Poly (methacrylic acid)‐based molecularly imprinted polymer nanoparticles containing 5‐fluourouracil used in colon cancer therapy potentially

Madadian-Bozorg

Zahedi

Shamsi

et al. 2018

Polymers for Advanced Techs

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The objective of this work was to synthesize molecularly imprinted polymer (MIP) nanoparticles based on methacrylic acid (MAA) monomer with a high selectivity against an anti-cancer drug, 5-fluorouracil (5-FU), as a template. In this case, the nanoparticles were prepared via precipitation polymerization in the presence of ethylene glycol dimethacrylate as cross-linker and azobisisobutyronitrile as initiator. Besides, 3 independent variables including MAA: 5-FU molar ratio (X 1 ), temperature (X 2 ), and time (X 3 ) were investigated utilizing response surface methodology. The scanning electron microscopy and dynamic light scattering resulted the average diameter of approximately 65 nm, and the MIP nanoparticle sample with the imprinting factor of 1.57 was polymerized in optimized conditions as follows: X 1 = 6: 1, X 2 = 60°C, and X 3 = 3 days in acetonitrile as porogenic solvent. Also, Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis confirmed the formation of MAA/5-FU complex and lower thermal stability of the washed MIP sample than the unwashed MIP and non-imprinted polymer (NIP) samples, respectively. Moreover, the optimized MIP nanoparticles have more controlled release of 5-FU rather than the NIP sample. Finally, the flow cytometry showed that 5-FU-loaded MIP sample has the highest apoptosis of human colon cancer cell line, HCT-116, after 3 days compared with NIP sample and also the exclusive use of drug.

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Section: Introductionmentioning

confidence: 99%

Poly (methacrylic acid)‐based molecularly imprinted polymer nanoparticles containing 5‐fluourouracil used in colon cancer therapy potentially

Madadian-Bozorg

Zahedi

Shamsi

et al. 2018

Polymers for Advanced Techs

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“…The Schiff-base reaction between free amine groups of N-succinyl-CS and aldehyde functionalities of Al-CS formed the cross-linked networks. Formation of Schiff base or imine is a reversible reaction, which is ideal for the degradation of hydrogel networks especially at lower pH due to the sensitivity of imine bond to the low pH [39,40].…”

Section: Hydrogel Preparationmentioning

confidence: 99%

“…The dry gel samples were weighed and immersed in a vial filled with PBS solution (pHs 7.4 and 4.5) and incubated at 37°C. The change in weight of the gels was recorded at regular intervals by removing the gels from the vial, blotting excess PBS, and then re-weighing [39].…”

Section: Degradation and Swellingmentioning

confidence: 99%

“…Components of each hydrogel set was prepared in MEM with related concentration (0.5 ml). The solutions were placed inside culture inserts (8 µm pore size, BD Falcon, USA) and mixed to form the corresponding hydrogel [27,39]. Once cross-linked, the inserts were transferred to pre-seeded wells (0.5 × 10 5 cells/ml, 24well polystyrene plates) and the plate was incubated at 37°C and 5% CO 2 .…”

Section: In Vitro Cytotoxicitymentioning

confidence: 99%

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In situ-forming and pH-responsive hydrogel based on chitosan for vaginal delivery of therapeutic agents

Jalalvandi

Shavandi

2018

J Mater Sci: Mater Med

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One of the important routes of drug administration for localized delivery of contraceptives and cervical cancer treatment agents is vaginal canal. Due to the low pH of vagina, a pH-responsive drug delivery system was developed. This hydrogel was synthesized based on a mucoadhesive biopolymer, chitosan (CS), that promotes the interaction between the hydrogel and mucosal surface of the vagina, potentially increasing the residence time of the system. This injectable hydrogel was formed via acid-labile Schiff-base linkages between free amine groups and aldehyde functionalities on modified chitosan. A novel approach was taken to add aldehyde functionalities to chitosan using a two-step reaction. Two types of slow and fast degrading hydrogels were prepared and loaded with iron (II) gluconate dihydrate, a non-hormonal spermicide, and doxorubicin hydrochloride, an anti-cancer drug. The release profiles of these drugs at different pH environments were assessed to determine the pH-dependent release mechanism. Mechanical properties, swell-ability and degradation rate of these matrices were studied. The cross-linking density of the hydrogel as well as pH changes played an important role in the characteristic of these hydrogels. The hydrogels degraded faster in lower pH, while the hydrogel with lower cross-linking density showed longer gelation time and faster degradation rate compared to the gel with higher cross-linking density. In vitro cytotoxicity assessment of these hydrogels in 48 h indicated the non-toxic effect of these hydrogels toward mesenchymal stem cells (MSCs) in the test period.

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“…Hydrogels are 3-D crosslinked matrices that can absorb and retain significant amount of water. These networks are crosslinked physically and/or chemically and are employed in various biomedical applications such as drug or cell delivery, tissue engineering, cell microenvironment engineering, wound dressing and sealants (Jalalvandi et al, 2018;Huang et al, 2017). Of various types of crosslinking methods, injectable hydrogels are particularly interesting for clinical use.…”

Section: Introductionmentioning

confidence: 99%

Shear thinning/self-healing hydrogel based on natural polymers with secondary photocrosslinking for biomedical applications

Jalalvandi

Shavandi

2019

Journal of the Mechanical Behavior of Biomedical Materials

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Preparation of a pH sensitive hydrogel based on dextran and polyhydrazide for release of 5-flurouracil, an anticancer drug

Cited by 20 publications

References 30 publications

Poly (methacrylic acid)‐based molecularly imprinted polymer nanoparticles containing 5‐fluourouracil used in colon cancer therapy potentially

Poly (methacrylic acid)‐based molecularly imprinted polymer nanoparticles containing 5‐fluourouracil used in colon cancer therapy potentially

In situ-forming and pH-responsive hydrogel based on chitosan for vaginal delivery of therapeutic agents

Shear thinning/self-healing hydrogel based on natural polymers with secondary photocrosslinking for biomedical applications

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